Skip to main content

Pharmaceutical Biotechnology in Herbal Neuroprotection

  • Chapter
  • First Online:
Biotechnology Products in Everyday Life

Part of the book series: EcoProduction ((ECOPROD))

Abstract

Plant-based herbal formulations were the only possible hope for health care management in ancient times. Along with the advancement of social and medical sciences, various drugs came in fashion to treat different diseases and clinical conditions and for a time, the interest in naturally derived compounds is waned. In the current era of biotechnology, where health sciences are at the peak of their advancements, herbal alternatives to synthetic drugs are again gathering tremendous interest. Why are herbal drugs of such interest? Maybe it is good to mention here about the less detrimental side effects of naturally derived compounds. Pharmaceutical biotechnology is a relatively new branch of science, which covers the advancements in pharmaceutical science by the involvement of biotechnological approaches and techniques. Along with the recent advancement of pharmaceutical biotechnology, utilization of compounds derived from medicinal plants for neuroprotection has increased worldwide. Although many synthetic compounds are commercially available nowadays for the patients of neurodegenerative disorders, search for novel herbal options for neuroprotection is still of great significance because of their less non-toxic and long-lasting nature. Without claiming to deal with all features of this topic, this chapter aims to provide a substantial and concise overview of the pharmaceutical biotechnology with a special emphasis in the area of herbal neuroprotection.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Wu, P., Zhang, Z., Wang, F., Chen, J.: Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury. Acta Pharmacol. Sin. 31, 1523–1531 (2010)

    Article  CAS  Google Scholar 

  2. WHO Neurological Disorders: Public Health Challenges. Available at http://www.who.int/mental_health/neurology/neurodiso/en/. Last Accessed at 20 Nov 2017

  3. Le, D.A., Wu, Y., Huang, Z., Matsushita, K., Plesnila, N., Augustinack, J.C., Hyman, B.T., Yuan, J., Kuida, K., Flavell, R.A., Moskowitz, M.A.: Caspase activation and neuroprotection in caspase-3-deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc. Nat. Acad. Sci. U. S. A. 99, 15188–15193 (2002)

    Google Scholar 

  4. Sultana, R., Perluigi, M., Butterfield, D.A.: Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the alzheimer disease brain. Free Radical Biol. Med. 62, 157–169 (2013)

    Google Scholar 

  5. Uddin, M.S., Nasrullah, M., Hossain, M.S., Rahman, M.M., Sarwar, M.S., Amran, M.S., et al.: Evaluation of nootropic activity of Persicaria flaccida on cognitive performance, brain antioxidant markers and acetylcholinesterase activity in rats: implication for the management of alzheimer’s disease. Am. J. Psyc. Neurosci. 4, 26–37 (2016)

    Google Scholar 

  6. Da Costa, I.M., Cavalcanti, J.R.L.P., De Queiroz, D.B., De Azevedo, E.P., do Rêgo, A.C.M., Filho, A.I., Parente, P., Botelho, M.A., Guzen, F.P.: Supplementation with herbal extracts to promote behavioral and neuroprotective effects in experimental models of Parkinson’s disease: a systematic review. Phytother. Res. 7, 959–970 (2017). https://doi.org/10.1002/ptr.5813

    Article  Google Scholar 

  7. Perry, E., Howes, M.J.: Medicinal plants in dementia therapy: herbal hopes for brain aging? CNS Neurosci. Ther. 17, 683–698 (2011). https://doi.org/10.1111/j.1755-5949.2010.00202.x

    Article  Google Scholar 

  8. Vajeda, F.J.: Neuroprotection and neurodegenerative disease. J. Clin. Neurosci. 9, 4–8 (2002). https://doi.org/10.1054/jocn.2001.1027

    Article  Google Scholar 

  9. Ramawat, K.G. (eds.): Herbal Drugs: Ethnomedicine to Modern Medicine. Springer, Berlin, ISBN 978-3-540-79115-7 (2009)

    Google Scholar 

  10. Lobo, V., Patil, A., Phatak, A., Chandra, N.: Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn. Rev. 4, 118–126 (2010)

    Article  CAS  Google Scholar 

  11. Harvey, A.L.: Medicines from nature: are natural products still relevant to drug discovery? Trends Pharmacol. Sci. 20, 196–198 (1999)

    Article  CAS  Google Scholar 

  12. Orhan, I.E., Loizzo, M.R., Khan, M.T.H.: Therapeutic approaches to neuroprotective activity by complementary and alternative medicines. Evid. Based Complement Alternat. Med. 2012, Article ID 376068, 2 p. http://dx.doi.org/10.1155/2012/376068

  13. Brahmachari, G. (Eds.) Discovery and Development of Neuroprotective Agents from Natural Products. Elsevier, Amsterdam, ISBN: 9780128097694 (2018)

    Google Scholar 

  14. Ahmad, N., Khan, Z., Hasan, N., Basit, A., Zohrameena, S.: Neuroprotective agents, natural plant herbs & drugs in ischemic stroke: a review. PharmaTutor 5, 29–36 (2017)

    CAS  Google Scholar 

  15. More, S.V., Kumar, H., Kang, S.K., Song, K., Lee, K., Choi, D.: Advances in neuroprotective ingredients of medicinal herbs by using cellular and animal models of Parkinson’s disease. Evid. Based Complement Alternat. Med. Article ID 957875, 15 p (2013). https://doi.org/10.1155/2013/957875

  16. Joshi, H., Parle, M.: Cholinergic basis of memory improving effect of cholinergic basis of memory improving effect of cholinergic basis of memory improving effect of Ocimum tenuiflorum Linn. Ind. J. Pharma. Sci. 68, 364–365 (2006)

    Article  Google Scholar 

  17. Kumar, V.M.H., Gupta, Y.K.: Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats. J. Ethnopharmacol. 79, 253–260 (2002)

    Article  Google Scholar 

  18. Chandrasekaran, K., Mehrabian, Z., Spinnewyan, B., Drieu, K., Kiskum, G.: Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia. Brain Res. 922, 282–292 (2001)

    Article  CAS  Google Scholar 

  19. Anand, T., Naika, M., Swamy, M.S., Khanum, F.: Antioxidant and DNA damage preventive properties of Bacopa monniera (L) Wettst. Free Rad. Antioxidants 1, 89–95 (2011)

    Google Scholar 

  20. Singh, H.K., Dhawan, B.N.: Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi) Indian. J. Pharmacol. 29, S359–S365 (1997)

    Google Scholar 

  21. Capasso, R., Izzo, A.A., Pinto, L., Bifulco, T., Vitobello, C., Mascolo, N.: Phytotherapy and quality of herbal medicines. Fitoterapia 71, S58–S65 (2000)

    Article  Google Scholar 

  22. Huang, S.S., Tsai, M.C., Chih, C.L., Hung, L.M., Tsai, S.K.: Resveratrol reduction of infarct size in Long- Evans rats subjected to focal cerebral ischemia. Life Sci. 69, 1057–1065 (2001)

    Article  CAS  Google Scholar 

  23. Lalkovičová, M., Danielisová, V.: Neuroprotection and antioxidants. Neural Regen. Res. 11(865-87), 4 (2016). https://doi.org/10.4103/1673-5374.184447

    Article  Google Scholar 

  24. Misharina, T.A., Fatkullina, L.D., Alinkina, S., Kozachenko, A.I., Nagler, L.G., Medvedeva, I.B., Goloshchapov, A.N., Burlakova, E.B.: Effects of low doses of essential oils on the antioxidant status of the erythrocytes, liver and the brain of mice. Appl. Bioche. Microbiol. 50, 101–107 (2014)

    Article  CAS  Google Scholar 

Download references

Acknowledgments

Authors are thankful to their respective institutions. Ms. Tabassum Zafar acknowledges Department of Biotechnology and the Ministry of Science and Technology, New Delhi, India for providing financial support.

Conflicts of Interest

The authors declare no conflict of interest. The funding agency had no role in the design of the study, collection, analyses, interpretation, writing of the manuscript, and the decision to publish the manuscript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tabassum Zafar .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Zafar, T., Shrivastava, V.K., Shaik, B. (2019). Pharmaceutical Biotechnology in Herbal Neuroprotection. In: Khoobchandani, M., Saxena, A. (eds) Biotechnology Products in Everyday Life. EcoProduction. Springer, Cham. https://doi.org/10.1007/978-3-319-92399-4_15

Download citation

Publish with us

Policies and ethics