Abstract
The paper presents the technology of gene expression profiles reducing based on the complex use of fuzzy logic methods, statistical criteria and Shannon entropy. Simulation of the reducing process has been performed with the use of gene expression profiles of lung cancer patients. The variance and the average absolute value were changed within the defined range from the minimum to the maximum value, and Shannon entropy from the maximum to the minimum value during the simulation process. 311 gene expression profiles from 7129 were removed as non-informativity during simulation process. The structural block diagram of the step-by-step data processing in order to remove non-informativity gene expression profiles has been proposed as the simulation results.
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Babichev, S.A., Kornelyuk, A.I., Lytvynenko, V.I., Osypenko, V.: Computational analysis of microarray gene expression profiles of lung cancer. Biopolym. Cell 32(1), 70–79 (2016). http://biopolymers.org.ua/content/32/1/070/
Babichev, S., Lytvynenko, V., Korobchynskyi, M., Taif, M.: Objective clustering inductive technology of gene expression sequences features. Commun. Comput. Inf. Sci. 716, 359–372 (2016). https://doi.org/10.1007/978-3-319-58274-0_29
Babichev, S., Lytvynenko, V., Skvor, J., Fiser, J.: Model of the objective clustering inductive technology of gene expression profiles based on SOTA and DBSCAN clustering algorithms. Adv. Intell. Syst. Comput. 689, 21–39 (2018). https://doi.org/10.1007/978-3-319-70581-1_2
Babichev, S., Taif, M.A., Lytvynenko, V., Osypenko, V.: Criterial analysis of gene expression sequences to create the objective clustering inductive technology. In: Proceeding of the 2017 IEEE 37th International Conference on Electronics and Nanotechnology, ELNANO 2017, pp. 244–248 (2017). http://ieeexplore.ieee.org/document/7939756/
Beer, D., Kardia, S.: Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat. Med. 8(8), 816–824 (2012). http://www.nature.com/nm/journal/v8/n8/full/nm733.html
Bodyanskiy, Y., Dolotov, A., Vynokurova, O.: Evolving spiking wavelet-neuro-fuzzy self-learning system. Appl. Soft Comput. J. 4(8), 252–258 (2014). https://doi.org/10.1016/j.asoc.2013.05.020
Bodyanskiy, Y., Vynokurova, O., Pliss, I., Peleshko, D., Rashkevych, Y.: Hybrid generalized additive wavelet-neuro-fuzzy-system and its adaptive learning. Adv. Intell. Syst. Comput. 470, 51–61 (2016). https://doi.org/10.1007/978-3-319-39639-2_5
Hu, Z., Bodyanskiy, Y.V., Tyshchenko, O.K., Samitova, V.O.: Fuzzy clustering data given in the ordinal scale. Int. J. Intell. Syst. Appl. (IJISA) 9(1), 67–74 (2017). https://doi.org/10.5815/ijisa.2017.01.07
Hu, Z., Bodyanskiy, Y.V., Tyshchenko, O.K., Samitova, V.O.: Fuzzy clustering data given on the ordinal scale based on membership and likelihood functions sharing. Int. J. Intell. Syst. Appl. (IJISA) 9(2), 1–9 (2017). https://doi.org/10.5815/ijisa.2017.02.01
Hu, Z., Bodyanskiy, Y.V., Tyshchenko, O.K., Samitova, V.O.: Possibilistic fuzzy clustering for categorical data arrays based on frequency prototypes and dissimilarity measures. Int. J. Intell. Syst. Appl. (IJISA) 9(5), 55–61 (2017). https://doi.org/10.5815/ijisa.2017.05.07
Hu, Z., Bodyanskiy, Y.V., Tyshchenko, O.K., Tkachov, V.M.: Fuzzy clustering data arrays with omitted observations. Int. J. Intell. Syst. Appl. (IJISA) 9(6), 24–32 (2017). https://doi.org/10.5815/ijisa.2017.06.03
Kondratenko, Y., Korobko, O., Kozlov, O.: Synthesis and optimization of fuzzy controller for thermoacoustic plant. Stud. Fuzziness Soft Comput. 342, 453–457 (2016). https://doi.org/10.1007/978-3-319-32229-2_31
Yaghoobi, H., Haghipour, S., Hamzeiy, H., Asadi-Khiavi, M.: A review of modeling techniques for genetic regulatory networks. J. Med. Sig. Sens. 2(1), 61–70 (2012). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592506/
Zadeh, L.: Fuzzy logic = computing with words. IEEE Trans. Fuzzy Syst. 4(2), 103–111 (1996). http://ieeexplore.ieee.org/document/493904/
Zak, D., Vadigepalli, R., Gonye, E., Doyle, F., Schwaber, J., Ogunnaike, B.: Unconventional systems analysis problem in molecular biology: a case study in gene regulatory network modeling. Comput. Chem. Eng. 29(3), 547–563 (2005). http://www.sciencedirect.com/science/article/pii/S0098135404002443
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Babichev, S., Lytvynenko, V., Gozhyj, A., Korobchynskyi, M., Voronenko, M. (2019). A Fuzzy Model for Gene Expression Profiles Reducing Based on the Complex Use of Statistical Criteria and Shannon Entropy. In: Hu, Z., Petoukhov, S., Dychka, I., He, M. (eds) Advances in Computer Science for Engineering and Education. ICCSEEA 2018. Advances in Intelligent Systems and Computing, vol 754. Springer, Cham. https://doi.org/10.1007/978-3-319-91008-6_55
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DOI: https://doi.org/10.1007/978-3-319-91008-6_55
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