Abstract
We study the existence of weak solutions to a mixture model for tumour growth that consists of a Cahn–Hilliard–Darcy system coupled with an elliptic reaction-diffusion equation. The Darcy law gives rise to an elliptic equation for the pressure that is coupled to the convective Cahn–Hilliard equation through convective and source terms. Both Dirichlet and Robin boundary conditions are considered for the pressure variable, which allow for the source terms to be dependent on the solution variables.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Adams, R.A., Fournier, J.J.F.: Sobolev spaces. Pure and Applied Mathematics, vol. 140, 2nd edn. Elsevier/Academic Press, Amsterdam (2003)
Bosia, S., Conti, M., Grasselli, M.: On the Cahn–Hilliard–Brinkman system. Commun. Math. Sci. 13(6), 1541–1567 (2015)
Chen, Y., Wise, S.M., Shenoy, V.B., Lowengrub, J.S.: A stable scheme for a nonlinear, multiphase tumor growth model with an elastic membrane. Int. J. Numer. Method Biomed. Eng. 30, 726–754 (2014)
Chen, Z., Huan, G., Ma, Y.: Computational Methods for Multiphase Flows in Porous Media. Society for Industrial and Applied Mathematics, Philadelphia (2006)
Colli, P., Gilardi, G., Hilhorst, D.: On a Cahn–Hilliard type phase field model related to tumor growth. Discrete Contin. Dyn. Syst. 35(6), 2423–2442 (2015)
Cristini, V., Li, X., Lowengrub, J.S., Wise, S.M.: Nonlinear simulations of solid tumor growth using a mixture model: Invasion and branching. J. Math. Biol. 58, 723–763 (2009)
Cristini, V., Lowengrub, J.: Multiscale Modeling of Cancer: An Integrated Experimental and Mathematical Modeling Approach. Cambridge University Press, Cambridge (2010)
Dai, M., Feireisl, E., Rocca, E., Schimperna, G., Schonbek, M.: Analysis of a diffuse interface model for multispecies tumor growth. Nonlinearity 30(4), 1639–1658 (2017)
DiBenedetto, E.: Degenerate Parabolic Equations. Universitext. Springer, New York (1993)
Feng, X., Wise, S.M.: Analysis of a Darcy-Cahn-Hilliard diffuse interface model for the Hele-Shaw flow and its fully discrete finite element approximation. SIAM J. Numer. Anal. 50, 1320–1343 (2012)
Frigeri, S., Grasselli, M., Rocca, E.: On a diffuse interface model of tumor growth. Eur. J. Appl. Math. 26, 215–243 (2015)
Garcke, H., Lam, K.F.: Analysis of a Cahn–Hilliard system with non-zero Dirichlet conditions modeling tumor growth with chemotaxis. Discrete Contin. Dyn. Syst. 37(8), 4277–4308 (2017)
Garcke, H., Lam, K.F.: Global weak solutions and asymptotic limits of a Cahn–Hilliard–Darcy system modelling tumour growth. AIMS Math. 1(3), 318–360 (2016)
Garcke, H., Lam, K.F.: Well-posedness of a Cahn–Hilliard–Darcy system modelling tumour growth with chemotaxis and active transport. Eur. J. Appl. Math. 28(2), 284–316 (2017)
Garcke, H., Lam, K.F., Rocca, E.: Optimal control of treatment time in a diffuse interface model of tumor growth. Appl. Math. Optim. (2017, to be appear). DOI:10.1007/s00245–017-9414-4
Garcke, H., Lam, K.F., Sitka, E., Styles, V.: A Cahn–Hilliard–Darcy model for tumour growth with chemotaxis and active transport. Math. Models Methods Appl. Sci. 26(6), 1095–1148 (2016)
Grisvard, P.: Elliptic Problems on Nonsmooth Domains. Volume Monographs and Studies in Mathematics, Vol 24. Pitman, Boston (1985)
Hawkins-Daarud, A., van der Zee, K.G., Oden, J.T.: Numerical simulation of a thermodynamically consistent four-species tumor growth model. Int. J. Numer. Method Biomed. Eng. 28, 3–24 (2012)
Jiang, J., Wu, H., Zheng, S.: Well-posedness and long-time behavior of a non-autonomous Cahn–Hilliard–Darcy system with mass source modeling tumor growth. J. Differ. Equ. 259(7), 3032–3077 (2015)
Lowengrub, J.S., Titi, E., Zhao, K.: Analysis of a mixture model of tumor growth. Eur. J. Appl. Math. 24, 691–734 (2013)
Oden, J.T., Hawkins, A., Prudhomme, S.: General diffuse-interface theories and an approach to predictive tumor growth modeling. Math. Models Methods Appl. Sci. 58, 723–763 (2010)
Simon, J.: Compact sets in space L p(0, T; B). Ann. Mat. Pura Appl. 146(1), 65–96 (1986)
Wang, X., Wu, H.: Long-time behavior for the Hele–Shaw–Cahn–Hilliard system. Asymptot. Anal. 78(4), 217–245 (2012)
Wang, X., Zhang, Z.: Well-posedness of the Hele–Shaw–Cahn–Hilliard system. Ann. Inst. H. Poincaré Anal. Non Linéaire. 30(3), 367–384 (2013)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Garcke, H., Lam, K.F. (2018). On a Cahn–Hilliard–Darcy System for Tumour Growth with Solution Dependent Source Terms. In: Rocca, E., Stefanelli, U., Truskinovsky, L., Visintin, A. (eds) Trends in Applications of Mathematics to Mechanics. Springer INdAM Series, vol 27. Springer, Cham. https://doi.org/10.1007/978-3-319-75940-1_12
Download citation
DOI: https://doi.org/10.1007/978-3-319-75940-1_12
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-75939-5
Online ISBN: 978-3-319-75940-1
eBook Packages: Mathematics and StatisticsMathematics and Statistics (R0)