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Immunogenic and Non-immunogenic Cell Death in the Tumor Microenvironment

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Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1036))

Abstract

The host immune system is continuously exposed to dying cells and has evolved to distinguish between cell death events signaling potential threats and physiological apoptosis that should be tolerated. Tumors can use this distinction to their advantage, promoting apoptotic death of cancer cells to induce tolerance and evasion of immunosurveillance. On the other hand, stimuli that cause immunogenic death of cancer cells can induce an effective anti-tumor immune response. In this chapter we discuss different forms of cell death in the tumor microenvironment, and how these interact with host immune cells to impact tumor progression and cancer therapy. We focus on how cancer cells hijack aspects of cell death to promote tumor survival, and how anti-cancer treatments that activate immunogenic death modalities give strong and durable clinical efficacy.

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Authors and Affiliations

  1. Gustave Roussy Cancer Campus, Villejuif, Cedex, France

    Jonathan M. Pitt, Guido Kroemer & Laurence Zitvogel

  2. INSERM U1015, Villejuif, France

    Jonathan M. Pitt & Laurence Zitvogel

  3. Faculté de Médecine, Université Paris Sud-XI, Le Kremlin Bicêtre, France

    Jonathan M. Pitt & Laurence Zitvogel

  4. INSERM U848, Villejuif, France

    Guido Kroemer

  5. Metabolomics Platform, Institut Gustave Roussy, Villejuif, France

    Guido Kroemer

  6. Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France

    Guido Kroemer

  7. Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France

    Guido Kroemer

  8. Université Paris Descartes-V, Sorbonne Paris Cité, Paris, France

    Guido Kroemer

  9. Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France

    Laurence Zitvogel

Authors
  1. Jonathan M. Pitt
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  2. Guido Kroemer
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  3. Laurence Zitvogel
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Corresponding author

Correspondence to Laurence Zitvogel .

Editor information

Editors and Affiliations

  1. Department of Medicine and Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, New York, USA

    Pawel Kalinski

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Pitt, J.M., Kroemer, G., Zitvogel, L. (2017). Immunogenic and Non-immunogenic Cell Death in the Tumor Microenvironment. In: Kalinski, P. (eds) Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy. Advances in Experimental Medicine and Biology, vol 1036. Springer, Cham. https://doi.org/10.1007/978-3-319-67577-0_5

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