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Regulation of CTL Infiltration Within the Tumor Microenvironment

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Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1036))

Abstract

The tumor microenvironment consists of a complex milieu of cells and factors that maintain equilibrium between tumor progression and destruction. Characterization of the immune contexture in primary tumors has consistently shown that T lymphocytes are an integral predictor of improved clinical outcome. This is notably true in colorectal carcinoma where high densities of cytotoxic or memory T lymphocytes in the invasive margin and the center of the primary tumor predict better patient survival, a measure termed Immunoscore. Since a high Immunoscore and pre-existing adaptive immune response are significantly correlated with improved clinical outcome, it is essential to understand the mechanisms underlying functional T lymphocyte infiltration into the tumor. The ability of cytolytic and memory T lymphocytes to migrate into tumors is regulated by multiple strategies including T lymphocyte help, homing factors, cytokines, tumor genotype, angiogenesis, lymphangiogenesis, and neurological signals. This chapter will discuss the predominant factors that mediate T-lymphocyte infiltration into tumors and how analysis of these biomarkers determine patients’ disease-related survival and predicts response to cancer therapy.

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Authors and Affiliations

  1. Laboratory of Integrative Cancer Immunology, INSERM, UMRS1138, 15 Rue de l’Ecole de Medecine, Paris, France

    Sarah E. Church & Jérôme Galon

  2. Université Paris Descartes, Paris, France

    Sarah E. Church & Jérôme Galon

  3. Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris, France

    Sarah E. Church & Jérôme Galon

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  1. Sarah E. Church
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  2. Jérôme Galon
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Correspondence to Sarah E. Church .

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  1. Department of Medicine and Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, New York, USA

    Pawel Kalinski

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Church, S.E., Galon, J. (2017). Regulation of CTL Infiltration Within the Tumor Microenvironment. In: Kalinski, P. (eds) Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy. Advances in Experimental Medicine and Biology, vol 1036. Springer, Cham. https://doi.org/10.1007/978-3-319-67577-0_3

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