Skip to main content

Design and Planning of Organ Transplantation Networks

  • Chapter
  • First Online:
Operations Research Applications in Health Care Management

Abstract

Organ transplantation is one of the most successful therapy methods for many fatal diseases. As the demand for organs exceeds the supply, donated organs are considered as important and scarce national resources. Hence, planning for organ transplantation network in different levels including strategic, tactical and operational is an attractive and controversial research area with significant practical relevance. Strategic planning for organ transplantation network deals with long-term decisions (e.g., Transplant Center (TC) and Organ Procurement Organization (OPO) location problems and regional configuration design problem), while tactical/operational planning associates with the procurement of organs and short-term decisions (e.g., organ allocation and transportation of organs, patients and medical staff). Organ transplantation network planning is constrained by specific limitations due to the perishability of organs and emergent nature of transplantation activity which differentiate it from regular supply chains. This chapter aims to introduce and discuss the recent developments in organ transplantation network planning as well as presenting relevant case studies. In particular, this chapter focuses on mathematical programming and computational models proposed in the recent literature for organ transplantation network planning. Moreover, a systematic classification of the relevant literature as well as a number of attractive future research directions are provided for interested readers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Ahn J-H, Hornberger JC (1996) Involving patients in the cadaveric kidney transplant allocation process: a decision-theoretic perspective. Manag Sci 42(5):629–641

    Article  Google Scholar 

  • Alagoz O, Maillart LM, Schaefer AJ, Roberts MS (2004) The optimal timing of living-donor liver transplantation. Manag Sci 50(10):1420–1430

    Article  Google Scholar 

  • Alagoz O, Maillart LM, Schaefer AJ, Roberts MS (2007) Determining the acceptance of cadaveric livers using an implicit model of the waiting list. Oper Res 55(1):24–36

    Article  Google Scholar 

  • Alagoz O, Schaefer AJ, Roberts MS (2009) Optimizing organ allocation and acceptance. In: Handbook of optimization in medicine, vol 26. Springer, pp 1–24

    Google Scholar 

  • Beliën J, De Boeck L, Colpaert J, Devesse S, Van den Bossche F (2013) Optimizing the facility location design of organ transplant centers. Decis Support Syst 54(4):1568–1579

    Article  Google Scholar 

  • Benjamin M (1988) Medical ethics and economics of organ transplantation. Health Prog (Saint Louis, Mo) 69(2):47–52

    Google Scholar 

  • Bertsimas D, Farias VF, Trichakis N (2013) Fairness, efficiency, and flexibility in organ allocation for kidney transplantation. Oper Res 61(1):73–87

    Article  Google Scholar 

  • Bruni ME, Conforti D, Sicilia N, Trotta S (2006) A new organ transplantation location–allocation policy: a case study of Italy. Health Care Manag Sci 9(2):125–142

    Article  Google Scholar 

  • Çay P (2012) Organ transplantation logistics: case for Turkey. Bilkent University

    Google Scholar 

  • Childress JF (2001) Putting patients first in organ allocation: an ethical analysis of the US debate. Camb Q Healthc Ethics 10(04):365–376

    Article  Google Scholar 

  • David I, Yechiali U (1985) A time-dependent stopping problem with application to live organ transplants. Oper Res 33(3):491–504

    Article  Google Scholar 

  • David I, Yechiali U (1990) Sequential assignment match processes with arrivals of candidates and offers. Probab Eng Informational Sci 4(04):413–430

    Article  Google Scholar 

  • David I, Yechiali U (1995) One-attribute sequential assignment match processes in discrete time. Oper Res 43(5):879–884

    Article  Google Scholar 

  • Demirci MC, Schaefer AJ, Romeijn HE, Roberts MS (2012) An exact method for balancing efficiency and equity in the liver allocation hierarchy. INFORMS J Comput 24(2):260–275

    Article  Google Scholar 

  • Friele R (2013) Study on the set-up of organ donation and transplantation in the EU Member States, uptake and impact of the EU Action Plan on Organ Donation and Transplantation (2009–2015)

    Google Scholar 

  • Fuzzati R (2005) Organ transplantation management. Swiss Federal Institute of Technology Lausanne (EPFL) Technical Report, No: IC/2005/022

    Google Scholar 

  • Howard DH (2002) Why do transplant surgeons turn down organs?: a model of the accept/reject decision. J Health Econ 21(6):957–969

    Article  Google Scholar 

  • Kazemeyni SM, Bagheri Chrime AR, Heidari AR (2004) Worldwide cadaveric organ donation systems (transplant organ procurement)

    Google Scholar 

  • Kong N, Schaefer AJ, Hunsaker B, Roberts MS (2010) Maximizing the efficiency of the US liver allocation system through region design. Manag Sci 56(12):2111–2122

    Article  Google Scholar 

  • Liu B (2004) Uncertainty theory: an introduction to its axiomatic foundations. Springer, Berlin

    Book  Google Scholar 

  • Liu B, Liu Y-K (2002) Expected value of fuzzy variable and fuzzy expected value models. IEEE Trans Fuzzy Syst 10(4):445–450

    Article  Google Scholar 

  • MOHME (2016) Ministry of health and medical education (Iran). http://www.behdasht.gov.ir/

  • OPTN (2016) Organ procurement and transplantation network. https://optn.transplant.hrsa.gov/

  • Roth AE, Sonmez T, Unver MU (2003) Kidney exchange. National bureau of economic research, Cambridge, MA

    Book  Google Scholar 

  • Stahl JE, Kong N, Shechter SM, Schaefer AJ, Roberts MS (2005) A methodological framework for optimally reorganizing liver transplant regions. Med Decis Mak 25(1):35–46

    Article  Google Scholar 

  • Su X, Zenios SA (2005) Patient choice in kidney allocation: a sequential stochastic assignment model. Oper Res 53(3):443–455

    Article  Google Scholar 

  • Su X, Zenios SA (2006) Recipient choice can address the efficiency-equity trade-off in kidney transplantation: a mechanism design model. Manag Sci 52(11):1647–1660

    Article  Google Scholar 

  • UNOS (2016) United network for organ sharing. https://www.unos.org/data/

  • WHO (2014) World Health Organization. http://www.who.int/topics/transplantation/en/

  • Zahiri B, Tavakkoli-Moghaddam R, Mohammadi M, Jula P (2014a) Multi-objective design of an organ transplant network under uncertainty. Transp Res Part E: Logist Transp Rev 72:101–124

    Article  Google Scholar 

  • Zahiri B, Tavakkoli-Moghaddam R, Pishvaee MS (2014b) A robust possibilistic programming approach to multi-period location–allocation of organ transplant centers under uncertainty. Comput Ind Eng 74:139–148

    Article  Google Scholar 

  • Zenios SA (1999) Modeling the transplant waiting list: a queueing model with reneging. Queueing Syst 31(3–4):239–251

    Article  Google Scholar 

  • Zenios SA (2004) Models for kidney allocation. In: Operations research and health care, vol 70. Springer, pp 537–554

    Google Scholar 

  • Zenios SA, Chertow GM, Wein LM (2000) Dynamic allocation of kidneys to candidates on the transplant waiting list. Oper Res 48(4):549–569

    Article  Google Scholar 

  • Zhu H, Zhang J (2009) A credibility-based fuzzy programming model for APP problem. In: Artificial intelligence and computational intelligence, 2009. AICI’09. International Conference on, 2009. IEEE, pp 455–459

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mir Saman Pishvaee .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ahmadvand, S., Pishvaee, M.S. (2018). Design and Planning of Organ Transplantation Networks. In: Kahraman, C., Topcu, Y. (eds) Operations Research Applications in Health Care Management. International Series in Operations Research & Management Science, vol 262. Springer, Cham. https://doi.org/10.1007/978-3-319-65455-3_9

Download citation

Publish with us

Policies and ethics