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Complicated Intra-abdominal Infections: Principles of Antimicrobial Therapy

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Abdominal Sepsis

Part of the book series: Hot Topics in Acute Care Surgery and Trauma ((HTACST))

Abstract

Antimicrobial therapy plays a crucial role in the management of complicated intra-abdominal infections. A correct approach for treating intra-abdominal infections always involves a delicate balance between the optimization of empirical therapy, which has been shown to improve clinical outcomes, and the reduction of excessive antimicrobial use. In particular, the indiscriminate use of broad-spectrum antimicrobials has been proven to increase the rate of emergence of anti-microbial resistant strains. The choice of antimicrobial therapy depends on the severity and type of intra-abdominal infections (e.g., community-acquired or hospital-acquired) as well as on the local resistance profiles. Adequate antimicrobial therapy, step-down to oral treatment, and prompt source control remain the mainstay for the management of complicated intra-abdominal infections.

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Authors and Affiliations

  1. Clinica Malattie Infettive, Dipartimento di Medicina, Università di Udine and Azienda Ospedaliera Universitaria Santa Maria della Misericordia, Presidio Ospedaliero Universitario Santa Maria della Misercordia, Piazzale Santa Maria della Misericordia 15, 33100, Udine, Italy

    Matteo Bassetti M.D., Ph.D. & Elda Righi

  2. Clinica Malattie Infettive, Santa Maria Misericordia Hospital, Azienda Ospedaliera Universitaria Santa Maria della Misericordia, Piazzale Santa Maria della Misericordia 15, 33100, Macerata, Italy

    Massimo Sartelli

Authors
  1. Matteo Bassetti M.D., Ph.D.
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  2. Elda Righi
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  3. Massimo Sartelli
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Corresponding author

Correspondence to Matteo Bassetti M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Surgery, Macerata Hospital, Macerata, Italy

    Massimo Sartelli

  2. University of Udine, Infectious Diseases Division , Udine, Italy

    Matteo Bassetti

  3. St James's University Hospital, Trinity Centre for Health Sciences , Dublin, Ireland

    Ignacio Martin-Loeches

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Bassetti, M., Righi, E., Sartelli, M. (2018). Complicated Intra-abdominal Infections: Principles of Antimicrobial Therapy. In: Sartelli, M., Bassetti, M., Martin-Loeches, I. (eds) Abdominal Sepsis. Hot Topics in Acute Care Surgery and Trauma. Springer, Cham. https://doi.org/10.1007/978-3-319-59704-1_16

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  • DOI: https://doi.org/10.1007/978-3-319-59704-1_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-59703-4

  • Online ISBN: 978-3-319-59704-1

  • eBook Packages: MedicineMedicine (R0)

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