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The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel

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Store-Operated Ca²⁺ Entry (SOCE) Pathways

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 993))

Abstract

This chapter focuses on the Orai proteins, Orai1–Orai3, with special emphasis on Orai1, in humans and other mammals, and on the definitive evidence that Orai is the pore subunit of the CRAC channel. It begins by reviewing briefly the defining characteristics of the CRAC channel, then discusses the studies that implicated Orai as part of the store-operated Ca2+ entry pathway and as the CRAC channel pore subunit, and finally examines ongoing work that is providing insights into CRAC channel structure and gating.

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Acknowledgments

The authors’ work on STIM-Orai signaling is funded by US National Institutes of Health grants AI084167 and GM110397.

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Authors and Affiliations

  1. Division of Signalling and Gene Expression, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, USA

    Aparna Gudlur & Patrick G. Hogan

Authors
  1. Aparna Gudlur
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  2. Patrick G. Hogan
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Correspondence to Aparna Gudlur or Patrick G. Hogan .

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Editors and Affiliations

  1. Institute of Biophysics, Medical University of Graz, Graz, Austria

    Klaus Groschner

  2. Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria

    Wolfgang F. Graier

  3. Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria

    Christoph Romanin

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Gudlur, A., Hogan, P.G. (2017). The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel. In: Groschner, K., Graier, W., Romanin, C. (eds) Store-Operated Ca²⁺ Entry (SOCE) Pathways. Advances in Experimental Medicine and Biology, vol 993. Springer, Cham. https://doi.org/10.1007/978-3-319-57732-6_3

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