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Unbalanced Growth, Senescence and Aging

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Cell Division Machinery and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1002))

Abstract

Usually, cells balance their growth with their division. Coordinating growth inputs with cell division ensures the proper timing of division when sufficient cell material is available and affects the overall rate of cell proliferation. At a very fundamental level, cellular replicative lifespan—defined as the number of times a cell can divide, is a manifestation of cell cycle control. Hence, control of mitotic cell divisions, especially when the commitment is made to a new round of cell division, is intimately linked to replicative aging of cells. In this chapter, we review our current understanding, and its shortcomings, of how unbalanced growth and division, can dramatically influence the proliferative potential of cells, often leading to cellular and organismal aging phenotypes. The interplay between growth and division also underpins cellular senescence (i.e., inability to divide) and quiescence, when cells exit the cell cycle but still retain their ability to divide.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, TX, 77845, USA

    Michael Polymenis

  2. The Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA

    Brian K. Kennedy

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  1. Michael Polymenis
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  1. Department of Cell Physiology and Metabolism, Faculty of Medicine, Geneva University, Geneva, Switzerland

    Monica Gotta

  2. Department of Cell Physiology and Metabolism, Faculty of Medicine, Geneva University, Geneva, Switzerland

    Patrick Meraldi

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Polymenis, M., Kennedy, B.K. (2017). Unbalanced Growth, Senescence and Aging. In: Gotta, M., Meraldi, P. (eds) Cell Division Machinery and Disease. Advances in Experimental Medicine and Biology, vol 1002. Springer, Cham. https://doi.org/10.1007/978-3-319-57127-0_8

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