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Assessment of Population Iodine Status

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Iodine Deficiency Disorders and Their Elimination

Abstract

Iodine deficiency is one of the most common micronutrient deficiencies, affecting 30 % of the world’s population. Iodine status in a population is usually assessed by urinary iodine concentration (UIC) in spot urine samples; UIC is associated with large inter- and intra-individual variation. Other biomarkers including thyroid-stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4) can be used to assess iodine status, however, the normal reference ranges are wide, making it difficult to use these to detect mild iodine deficiency. Another thyroid-specific protein, thyroglobulin (Tg), is considered to be more sensitive to improvements of iodine status in mildly iodine deficient populations but validated cut-offs for adults are lacking. Dietary assessment methods often underestimate iodine intake because of the difficulty in accurately quantifying the contribution of iodized salt to total iodine intake. Future research should focus on the development and validation of more accurate and reliable biomarkers, particularly for individuals.

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Authors and Affiliations

  1. Department of Human Nutrition, University of Otago, Dunedin, 9054, New Zealand

    Zheng Feei Ma PhD & Sheila A. Skeaff PhD

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  1. Boston University School of Medicine, Boston, Massachusetts, USA

    Elizabeth N. Pearce

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Ma, Z.F., Skeaff, S.A. (2017). Assessment of Population Iodine Status. In: Pearce, E. (eds) Iodine Deficiency Disorders and Their Elimination. Springer, Cham. https://doi.org/10.1007/978-3-319-49505-7_2

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