Abstract
Retrotransposition, the ability of retrotransposons to move to different locations within the genome via an RNA intermediate, has been for many years at the forefront of research into the role of these elements in cancer. Indeed, it is intuitive to envisage the mutational and cancer-promoting effects of retrotransposition, given the dramatic effects on genome structure inherent in mobilization. Nevertheless, recent work has revealed that retrotransposition is only one of the ways in which retrotransposons can impact genome function. This realization has spurred a new wave of interest into the potential of these elements to control neighboring genes, a property that was emphasized by Barbara McClintock when she first discovered these elements in maize. In this chapter, we will focus on the relationship between the mobilization-independent effects of aberrant activation of retrotransposon promoters, and cancer.
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Work in CT lab is supported by the Derby Colorectal Cancer Fund, in RB lab by the University of Leicester.
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Tufarelli, C., Badge, R.M. (2017). Retrotransposon-Driven Transcription and Cancer. In: Cristofari, G. (eds) Human Retrotransposons in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-48344-3_11
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