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Lymph Node

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Immunopathology in Toxicology and Drug Development

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

Lymph nodes are essential for the initiation of the adaptive immune response as they create an environment that filters antigens and pathogens and provide a site for antigen presentation to lymphocytes. Immunologically, responses to the various antigens can be reflected in lymph node histology. These responses can be proliferative or nonproliferative and can be incidental. Species, strain, age of animal, health status, and the type and route of administration of a test article should always be a consideration when evaluating the lymph node. Understanding the physiology and histomorphologic features of the lymph node and alterations of normal lymph node histology are critical to differentiate lesions that occur naturally during development and aging from those that may be treatment related.

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Author information

Authors and Affiliations

  1. National Toxicology Program, National Institute of Environmental Health Sciences, 111 Alexander Drive, Bldg 101, Rm B-327, Research Triangle Park, NC, 27709, USA

    Susan A. Elmore M.S., D.V.M.

  2. Charles River Laboratories, Inc., 4025 Stirrup Creek Drive, Suite 150, Durham, NC, USA

    Schantel A. Bouknight D.V.M., Ph.D.

Authors
  1. Susan A. Elmore M.S., D.V.M.
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  2. Schantel A. Bouknight D.V.M., Ph.D.
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Corresponding author

Correspondence to Susan A. Elmore M.S., D.V.M. .

Editor information

Editors and Affiliations

  1. Charles River Laboratories, Inc., Durham, North Carolina, USA

    George A. Parker

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© 2017 Springer International Publishing AG

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Elmore, S.A., Bouknight, S.A. (2017). Lymph Node. In: Parker, G. (eds) Immunopathology in Toxicology and Drug Development. Molecular and Integrative Toxicology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-47385-7_3

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