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Animal Models to Study AMPK

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AMP-activated Protein Kinase

Part of the book series: Experientia Supplementum ((EXS,volume 107))

Abstract

AMPK is an evolutionary conserved energy sensor involved in the regulation of energy metabolism. Based on biochemical studies, AMPK has brought much of interest in recent years due to its potential impact on metabolic disorders. Suitable animal models are therefore essential to promote our understanding of the molecular and functional roles of AMPK but also to bring novel information for the development of novel therapeutic strategies. The organism systems include pig (Sus scrofa), mouse (Mus musculus), fly (Drosophila melanogaster), worm (Caenorhabditis elegans), and fish (Danio rerio) models. These animal models have provided reliable experimental evidence demonstrating the crucial role of AMPK in the regulation of metabolism but also of cell polarity, autophagy, and oxidative stress. In this chapter, we update the new development in the generation and application of animal models for the study of AMPK biology. We also discuss recent breakthroughs from studies in mice, flies, and worms showing how AMPK has a primary role in initiating or promoting pathological or beneficial impact on health.

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Authors and Affiliations

  1. INSERM U1016, Institut Cochin, Paris, France

    Benoit Viollet & Marc Foretz

  2. CNRS UMR 8104, Paris, France

    Benoit Viollet & Marc Foretz

  3. Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Benoit Viollet & Marc Foretz

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  1. Benoit Viollet
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  2. Marc Foretz
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Correspondence to Benoit Viollet .

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Editors and Affiliations

  1. Oral Medicine Department, Universidad de Sevilla, Sevilla, Spain

    Mario D. Cordero

  2. INSERM U1016 Institut Cochin CNRS UMR 8104, Université Paris Descartes, Paris, France

    Benoit Viollet

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Viollet, B., Foretz, M. (2016). Animal Models to Study AMPK. In: Cordero, M., Viollet, B. (eds) AMP-activated Protein Kinase. Experientia Supplementum, vol 107. Springer, Cham. https://doi.org/10.1007/978-3-319-43589-3_18

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