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Functional Salivary Gland Regeneration by Organ Replacement Therapy

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Salivary Gland Development and Regeneration

Abstract

The salivary glands are exocrine organs that secrete saliva to maintain oral health and homeostasis. Dysfunctional salivary glands exhibit symptoms of dry mouth, including dental caries and dysfunction in speech and swallowing. Current clinical therapies for dry mouth disease include artificial saliva substitutes or parasympathetic stimulants, but these are transient and palliative approaches. To achieve the functional recovery of dysfunctional salivary glands, salivary gland tissue stem cells are thought to be candidate cell sources for salivary gland tissue repair therapies. In addition, whole salivary gland replacement therapy is expected to be a novel therapy resulting in the regeneration of fully functional salivary glands. The salivary glands arise from their organ germs, which are induced by epithelial-mesenchymal interactions. Recently, we developed a novel bioengineering method, i.e., the organ germ method, which can regenerate the ectodermal organs, including the teeth, hair, lacrimal glands, and salivary glands. The bioengineered salivary glands successfully secrete saliva into the oral cavity and can also improve the symptoms of dry mouth, such as bacterial infection and swallowing dysfunction. In this review, we summarize recent findings and bioengineering methods for salivary gland regeneration therapy.

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Acknowledgments

This work was partially supported by a Grant-in-Aid for KIBAN (A) from the Ministry of Education, Culture, Sports, Science and Technology (no. 25242041). This work was also partially supported by Organ Technologies, Inc.

Conflict of Interest

This work was partially funded by Organ Technologies Inc. M.O. is a researcher and T.T. is a director at Organ Technologies Inc. This work was performed under an Invention Agreement between Tokyo University of Science, RIKEN and Organ Technologies Inc.

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Authors and Affiliations

  1. Organ Technologies Inc., Tokyo, 101-0048, Japan

    Miho Ogawa PhD & Takashi Tsuji PhD

  2. RIKEN Center for Developmental Biology, Kobe, Hyogo, 650-0047, Japan

    Miho Ogawa PhD & Takashi Tsuji PhD

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  1. Miho Ogawa PhD
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  2. Takashi Tsuji PhD
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Correspondence to Takashi Tsuji PhD .

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Editors and Affiliations

  1. Oral and Maxillofacial Diagnostic Sciences, University of Florida, Gainesville, Florida, USA

    Seunghee Cha

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Ogawa, M., Tsuji, T. (2017). Functional Salivary Gland Regeneration by Organ Replacement Therapy. In: Cha, S. (eds) Salivary Gland Development and Regeneration. Springer, Cham. https://doi.org/10.1007/978-3-319-43513-8_10

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  • DOI: https://doi.org/10.1007/978-3-319-43513-8_10

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