Abstract
From a macroscopic point of view, the inflammatory process is considered an event for which it is possible to identify a beginning and an endpoint, typically represented by the appearance and subsequent disappearance of the classical signs and symptoms (rubor, tumor, calor, dolor, fluor and functio laesa), respectively [1, 2].
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References
Freire MO, Van Dyke TE (2013) Natural resolution of inflammation. Periodontology 2000 63(1):149–164
Alessandri AL, Sousa LP, Lucas CD, Rossi AG, Pinho V et al (2013) Resolution of inflammation: mechanisms and opportunity for drug development. Pharmacol Ther 139(2):189–212
Madhumitha H, Mohan V, Deepa M, Babu S, Aravindhan V (2014) Increased Th1 and suppressed Th2 serum cytokine levels in subjects with diabetic coronary artery disease. Cardiovasc Diabetol 13:1
Eljaafari A, Robert M, Chehimi M, Chanon S, Durand C et al (2015) Adipose tissue-derived stem cells from obese subjects contribute to inflammation and reduced insulin response in adipocytes through differential regulation of the Th1/Th17 balance and monocyte activation. Diabetes 64(7):2477–2488
Franceschi C, Campisi J (2014) Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci 69 [Suppl 1]:S4–S9
Pinti M, Cevenini E, Nasi M, De Biasi S, Salvioli S et al (2014) Circulating mitochondrial DNA increases with age and is a familiar trait: implications for “inflamm-aging”. Eur J Immunol 44(5):1552–1562
Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M et al (2000) Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 908:244–254
Barbaresko J, Koch M, Schulze MB, Nöthlings U (2013) Dietary pattern analysis and biomarkers of low-grade inflammation: a systematic literature review. Nutr Rev 71(8):511–527
Hueston CM, Deak T (2014) The inflamed axis: the interaction between stress, hormones, and the expression of inflammatory-related genes within key structures comprising the hypothalamic-pituitary-adrenal axis. Physiol Behav 124:77–91
Lee H, Lee IS, Choue R (2013) Obesity, inflammation and diet. Pediatr Gastroenterol Hepatol Nutr 16(3):143–152
Carman JA, Vlieger HR, Ver Steeg LJ et al (2013) A long-term toxicology study on pigs fed a combined genetically modified (GM) soy and GM maize diet. J Org Syst 8(1):38–54
Samsel A, Seneff S (2013) Glyphosate’s suppression of cytochrome P450 enzymes and amino acid biosynthesis by the gut microbiome: pathways to modern diseases. Entropy 15(4):1416–1463
Adler UC (2011) Low-grade inflammation in chronic diseases: an integrative pathophysiology anticipated by homeopathy? Med Hypotheses 76(5):622–626
Lee BJ, Bak YT (2011) Irritable bowel syndrome, gut microbiota and probiotics. J Neurogastroenterol Motil 17(3):252–266
Henson J, Yates T, Edwardson CL, Khunti K, Talbot D et al (2013) Sedentary time and markers of chronic low-grade inflammation in a high risk population. PLoS One 8(10):e78350
Festi D, Schiumerini R, Eusebi LH, Marasco G, Taddia M et al (2014) Gut microbiota and metabolic syndrome. World J Gastroenterol 20(43):16079–16094
Fujimura KE, Slusher NA, Cabana MD, Lynch SV (2010) Role of the gut microbiota in defining human health. Expert Rev Anti Infect Ther 8(4):435–454
Bauer PV, Hamr SC, Duca FA (2016) Regulation of energy balance by a gut-brain axis and involvement of the gut microbiota. Cell Mol Life Sci 73(4):737–755
Bercik P, Collins SM (2014) The effects of inflammation, infection and antibiotics on the microbiota-gut-brain axis. Adv Exp Med Biol 817:279–289
Collins SM, Bercik P (2009) The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology 136(6):2003–2014
Forsythe P, Kunze WA, Bienenstock J (2012) On communication between gut microbes and the brain. Curr Opin Gastroenterol 28(6):557–562
Kovatcheva-Datchary P, Arora T (2013) Nutrition, the gut microbiome and the metabolic syndrome. Best Pract Res Clin Gastroenterol 27(1):59–72
Olivares M, Laparra JM, Sanz Y (2013) Host genotype, intestinal microbiota and inflammatory disorders. Br J Nutr 109 [Suppl 2]:S76–S80
Hughes PA, Zola H, Penttila IA, Blackshaw LA, Andrews JM et al (2013) Immune activation in irritable bowel syndrome: can neuroimmune interactions explain symptoms? Am J Gastroenterol 108(7):1066–1074
Kelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G et al (2015) Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci 9:392
De Punder K, Pruimboom L (2015) Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability. Front Immunol 6:223
Pietrzyk L, Torres A, Maciejewski R, Torres K (2015) Obesity and obese-related chronic low-grade inflammation in promotion of colorectal cancer development. Asian Pac J Cancer Prev 16(10):4161–4168
Esser N, Paquot N, Scheen AJ (2015) Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease. Expert Opin Investig Drugs 24(3):283–307
Wojdasiewicz P, Poniatowski ŁA, Szukiewicz D (2014) The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm 2014:561459
Bleau C, Karelis AD, St-Pierre DH, Lamontagne L (2015) Crosstalk between intestinal microbiota, adipose tissue and skeletal muscle as an early event in systemic low-grade inflammation and the development of obesity and diabetes. Diabetes Metab Res Rev 31(6):545–561
Jin C, Flavell RA (2013) Innate sensors of pathogen and stress: linking inflammation to obesity. J Allergy Clin Immunol 132(2):287–294
Berger S, Raman G, Vishwanathan R, Jacques PF, Johnson EJ (2015) Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis. Am J Clin Nutr 102(2):276–294
Stojanović S, Ilić MD, Ilić S, Petrović D, Djukić S (2015) The significance of adiponectin as a biomarker in metabolic syndrome and/or coronary artery disease. Vojnosanit Pregl 72(9):779–784
Turker Y, Baltaci D, Turker Y, Ozturk S, Sonmez CI et al (2015) Investigation of relationship of visceral body fat and inflammatory markers with metabolic syndrome and its components among apparently healthy individuals. Int J Clin Exp Med 8(8):13067–13077
Larsen SB, Grove EL, Würtz M, Neergaard-Petersen S, Hvas AM et al (2015) The influence of low-grade inflammation on platelets in patients with stable coronary artery disease. Thromb Haemost 114(3):519–529
Guarner V, Rubio-Ruiz ME (2015) Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease. Interdiscip Top Gerontol 40:99–106
Corrado E, Rizzo M, Coppola G, Fattouch K, Novo G et al (2010) An update on the role of markers of inflammation in atherosclerosis. J Atheroscler Thromb 17(1):1–11
Bustamante A, Sobrino T, Giralt D, García-Berrocoso T, Llombart V et al (2014) Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis. J Neuroimmunol 274(1-2):215–224
Kaptoge S, Seshasai SR, Gao P, Freitag DF, Butterworth AS et al (2014) Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis. Eur Heart J 35(9):578–589
Dinarello CA, van der Meer JW (2013) Treating inflammation by blocking interleukin-1 in humans. Semin Immunol 25(6):469–484
Spinas E, Kritas SK, Saggini A, Mobili A, Caraffa A et al (2014) Role of mast cells in atherosclerosis: a classical inflammatory disease. Int J Immunopathol Pharmacol 27(4):517–521
Wollert KC, Drexler H (2001) The role of interleukin-6 in the failing heart. Heart Fail Rev 6(2):95–103
Nicklas BJ, Penninx BW, Cesari M, Kritchevsky SB, Newman AB et al (2004) Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study. Am J Epidemiol 160(8):741–749
Dessein PH, Solomon A, Woodiwiss AJ, Norton GR, Tsang L et al (2013) Marked independent relationship between circulating interleukin-6 concentrations and endothelial activation in rheumatoid arthritis. Mediators Inflamm 2013:510243
Nishida H, Horio T, Suzuki Y, Iwashima Y, Tokudome T et al (2011) Interleukin-6 as an independent predictor of future cardiovascular events in high-risk Japanese patients: comparison with C-reactive protein. Cytokine 53(3):342–346
Su D, Li Z, Li X, Chen Y, Zhang Y et al (2013) Association between serum interleukin-6 concentration and mortality in patients with coronary artery disease. Mediators Inflamm 2013:726178
Kon V, Yang H, Fazio S (2015) Residual cardiovascular risk in chronic kidney disease: role of high-density lipoprotein. Arch Med Res 46(5):379–391
Wang AY, Lam CW, Chan IH, Wang M, Lui SF et al (2010) Sudden cardiac death in end-stage renal disease patients: a 5-year prospective analysis. Hypertension 56(2):210–216
Elewa U, Sanchez-Niño MD, Martin-Cleary C, Fernandez-Fernandez B, Egido J et al (2012) Cardiovascular risk biomarkers in CKD: the inflammation link and the road less traveled. Int Urol Nephrol 44(6):1731–1744
Dai X, Wang B (2015) Role of gut barrier function in the pathogenesis of nonalcoholic Fatty liver disease. Gastroenterol Res Pract 2015:287348
Vajro P, Paolella G, Fasano A (2013) Microbiota and gut-liver axis: their influences on obesity and obesity-related liver disease. J Pediatr Gastroenterol Nutr 56(5):461–468
Compare D, Coccoli P, Rocco A, Nardone OM, De Maria S et al (2012) Gut–liver axis: the impact of gut microbiota on non alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 22(6):471–476
Minemura M, Shimizu Y (2015) Gut microbiota and liver diseases. World J Gastroenterol 21(6):1691–1702
Saito T, Mochizuki T, Uchida K, Tsuchiya K, Nitta K (2013) Metabolic syndrome and risk of progression of chronic kidney disease: a single-center cohort study in Japan. Heart Vessels 28(3):323–329
Ferolla SM, Silva LC, de Lourdes Abreu Ferrari M, da Cunha AS, dos Santos Martins F et al (2015) Dietary approach in the treatment of nonalcoholic fatty liver disease. World J Hepatol 7(24):2522–2534
Lim S, Oh TJ, Koh KK (2015) Mechanistic link between nonalcoholic fatty liver disease and cardiometabolic disorders. Int J Cardiol 201:408–414
Lonardo A, Sookoian S, Pirola CJ, Targher G (2015) Non-alcoholic fatty liver disease and risk of cardiovascular disease. Metabolism 65(8):1136–1150
Than NN, Newsome PN (2015) A concise review of non-alcoholic fatty liver disease. Atherosclerosis 239(1):192–202
Giannelli V, Di Gregorio V, Iebba V, Giusto M, Schippa S et al (2014) Microbiota and the gut-liver axis: bacterial translocation, inflammation and infection in cirrhosis. World J Gastroenterol 20(45):16795–16810
Barrios C, Beaumont M, Pallister T, Villar J, Goodrich JK et al (2015) Gut-microbiota-metabolite axis in early renal function decline. PLoS One 10(8):e0134311
Dan Dunn J, Alvarez LA, Zhang X, Soldati T (2015) Reactive oxygen species and mitochondria: a nexus of cellular homeostasis. Redox Biol 6:472–485
Brady NR, Hamacher-Brady A, Westerhoff HV, Gottlieb RA (2006) A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria. Antioxid Redox Signal 8(9–10):1651–1665
Gusdon AM, Fernandez-Bueno GA, Wohlgemuth S, Fernandez J, Chen J et al (2015) Respiration and substrate transport rates as well as reactive oxygen species production distinguish mitochondria from brain and liver. BMC Biochem 16:22
El Assar M, Angulo J, Rodríguez-Mañas L (2013) Oxidative stress and vascular inflammation in aging. Free Radic Biol Med 65:380–401
Ballinger SW (2005) Mitochondrial dysfunction in cardiovascular disease. Free Radic Biol Med 38(10):1278–1295
Mikhed Y, Daiber A, Steven S (2015) Mitochondrial oxidative stress, mitochondrial DNA damage and their role in age-related vascular dysfunction. Int J Mol Sci 16(7):15918–15953
Yao X, Carlson D, Sun Y, Ma L, Wolf SE et al (2015) Mitochondrial ROS induces cardiac inflammation via a pathway through mtDNA damage in a pneumonia-related sepsis model. PLoS One 10(10):e0139416
Willems PH, Rossignol R, Dieteren CE, Murphy MP, Koopman WJ (2015) Redox homeostasis and mitochondrial dynamics. Cell Metab 22(2):207–218
Singh S, Zhuo M, Gorgun FM, Englander EW (2013) Overexpressed neuroglobin raises threshold for nitric oxide-induced impairment of mitochondrial respiratory activities and stress signaling in primary cortical neurons. Nitric Oxide 32:21–28
Bogeski I, Niemeyer BA (2014) Redox regulation of ion channels. Antioxid Redox Signal 21(6):859–862
Tocchi A, Quarles EK, Basisty N, Gitari L, Rabinovitch PS (2015) Mitochondrial dysfunction in cardiac aging. Biochim Biophys Acta 1847(11):1424–1433
Herrera A, Garcia I, Gaytan N, Jones E, Maldonado A et al (2015) Endangered species: mitochondrial DNA loss as a mechanism of human disease. Front Biosci (Schol Ed) 7:109–124
Sobenin IA, Zhelankin AV, Mitrofanov KY, Sinyov VV, Sazonova MA et al (2015) Mutations of mitochondrial DNA in atherosclerosis and atherosclerosis-related diseases. Curr Pharm Des 21(9):1158–1163
Koene S, Smeitink J (2011) Mitochondrial medicine. J Inherit Metab Dis 34(2):247–248
Fukai T, Ushio-Fukai M (2011) Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal 15(6):1583–1606
Harrison CM, Pompilius M, Pinkerton KE, Ballinger SW (2011) Mitochondrial oxidative stress significantly influences atherogenic risk and cytokine-induced oxidant production. Environ Health Perspect 119(5):676–681
Yang YK, Wang LP, Chen L, Yao XP, Yang KQ et al (2015) Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction. Clin Chim Acta 450:83–89
Forsberg E, Xu C, Grünler J, Frostegård J, Tekle M et al (2015) Coenzyme Q10 and oxidative stress, the association with peripheral sensory neuropathy and cardiovascular disease in type 2 diabetes mellitus. J Diabetes Complications 29(8):1152–1158
Linnane AW, Kios M, Vitetta L (2007) Coenzyme Q(10) – its role as a prooxidant in the formation of superoxide anion/hydrogen peroxide and the regulation of the metabolome. Mitochondrion 7(Suppl):S51–S61
Smith BJ, Lightfoot SA, Lerner MR, Denson KD, Morgan DL et al (2009) Induction of cardiovascular pathology in a novel model of low-grade chronic inflammation. Cardiovasc Pathol 18(1):1–10
Ungvari Z, Kaley G, de Cabo R, Sonntag WE, Csiszar A (2010) Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci 65(10):1028–1041
Ristow M (2014) Unraveling the truth about antioxidants: mitohormesis explains ROS-induced health benefits. Nat Med 20(7):709–711
Ristow M, Schmeisser K (2014) Mitohormesis: promoting health and lifespan by increased levels of reactive oxygen species (ROS). Dose Response 12(2):288–341
Poljsak B, Šuput D, Milisav I (2013) Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxid Med Cell Longev 2013:956792
Tikhaze AK, Konovalova GG, Lankin VZ, Kaminnyi AI, Kaminnaja VI et al (2005) Effect of ubiquinone Q(10) and antioxidant vitamins on free radical oxidation of phospholipids in biological membranes of rat liver. Bull Exp Biol Med 140(2):181–183
Ghosh R, Alajbegovic A, Gomes AV (2015) NSAIDs and cardiovascular diseases: role of reactive oxygen species. Oxid Med Cell Longev 2015:536962
Taubert KA (2008) Cardiology patient pages. Can patients with cardiovascular disease take nonsteroidal antiinflammatory drugs? Circulation 117(17):e322–e324
Habib I, Mazulis A, Roginsky G, Ehrenpreis ED (2014) Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: pathophysiology and clinical associations. Inflamm Bowel Dis 20(12):2493–2502
Lotti T, Perra A (2014) Bases and principles of low dose medicine and P.N.E.I. foundations of low dose pharmacology. Pigm Disord 1:e101
Fioranelli M, Roccia MG (2014) Twenty-five years of studies and trials for the therapeutic application of IL-10 immunomodulating properties. From high doses administration to low dose medicine new paradigm. J Integr Cardiol 1(1):2–6
Gariboldi S, Palazzo M, Zanobbio L, Dusio GF, Mauro V et al (2009) Low dose oral administration of cytokines for treatment of allergic asthma. Pulm Pharmacol Ther 22:497–510
D’Amico L, Ruffini E, Ferracini R, Roato I (2012) Low dose of IL-12 stimulates T cell response in cultures of PBMCs derived from non-small cell lung cancer patients. J Cancer Ther 3:337–342
Cardani D, Dusio GF, Luchini P, Sciarabba M, Solimene U et al (2013) Oral administration of interleukin-10 and anti-IL-1 antibody ameliorates experimental intestinal inflammation. Gastroenterol Res 6:124–133
Radice E, Miranda V, Bellone G (2014) Low-doses of sequential-kinetic-activated interferon-gamma enhance the ex vivo cytotoxicity of peripheral blood natural killer cells from patients with early-stage colorectal cancer. A preliminary study. Int Immunopharmacol 19:66–73
Roberti ML, Ricottini L, Capponi A, Sclauzero E, Vicenti P et al (2014) Immunomodulating treatment with low dose Interleukin-4, Interleukin-10 and Interleukin-11 in psoriasis vulgaris. J Biol Regul Homeost Agents 28:133–139
Luchetti P (2014) Increasing of visual function in patients with retinal atrophy treated with drugs of Low Dose Medicine. Monocentric retrospective observational study. Minerva Oftalmol 56(3-4):53–61
Barygina V, Becatti M, Lotti T, Moretti S, Taddei N et al (2015) Treatment with low-dose cytokines reduces oxidative-mediated injury in perilesional keratinocytes from vitiligo skin. J Dermatol Sci 79(2):163–170
Lotti T, Hercogova J, Wollina U, Chokoeva AA, Zarrab Z et al (2015) Vitiligo: successful combination treatment based on oral low dose cytokines and different topical treatments. J Biol Regul Homeost Agents 29 [1 Suppl]:53–58
Radice E, Bellone G, Miranda V (2015) Enhancement of the immunostimulatory functions of ex vivo-generated dendritic cells from early-stage colon cancer patients by consecutive exposure to low doses of sequential-kinetic-activated IL-4 and IL-12. A preliminary study. Transl Oncol 8(4):327–338
Lotti T (2015) Successful combination treatment for psoriasis with phototherapy and low-dose cytokines: a spontaneous, retrospective observational clinical study. Hautarzt 66(11):849–854
Tessaro I, Modina SC, Franciosi F, Sivelli G, Terzaghi L, Lodde V et al (2015) Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome. J Ovarian Res 8(1):64
Porozov S, Cahlon L, Weiser M, Branski D, Lider O et al (2004) Inhibition of IL-lβ and TNF-α secretion from resting and activated human immunocytes by the homeopathic medication Traumeel®S. Clin Dev Immunol 11(2):143
González de Vega C, Speed C, Wolfarth B, González J (2013) Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: a multicentre, randomised, blinded, controlled and non-inferiority trial. Int J Clin Pract 67(10):979–989
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Fioranelli, M., Del Prete, M., Aracena, J.C., Roccia, M.G., Dal Lin, C., Tomella, C. (2017). Low-Dose Therapy for the Treatment of Low-Grade Chronic Inflammation. In: Fioranelli, M. (eds) Integrative Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-319-40010-5_3
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