Skip to main content

Vagal Nerve Stimulation for Drug-Resistant Epilepsy: Adverse Events and Outcome in a Series of Patients with Long-Term Follow-Up

  • Conference paper
Trends in Reconstructive Neurosurgery

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures. The Vagus Nerve Stimulation Study Group. Neurology 45:224–230 (1995)

    Google Scholar 

  2. Amar AP, Apuzzo ML, Liu CY (2004) Vagus nerve stimulation therapy after failed cranial surgery for intractable epilepsy: results from the vagus nerve stimulation therapy patient outcome registry. Neurosurgery 55:1086–1093

    Article  PubMed  Google Scholar 

  3. Amar AP, Heck CN, Levy ML, Smith T, DeGiorgio CM, Oviedo S et al (1998) An institutional experience with cervical vagus nerve trunk stimulation for medically refractory epilepsy: rationale, technique, and outcome. Neurosurgery 43(6):1265–1276; discussion 1276–1280

    CAS  PubMed  Google Scholar 

  4. Blount JP, Tubbs RS, Kankirawatana P, Kiel S, Knowlton R, Grabb PA, Bebin M (2006) Vagus nerve stimulation in children less than 5 years old. Childs Nerv Syst 22(9):1167–1169

    Article  PubMed  Google Scholar 

  5. Connor DE Jr, Nixon M, Nanda A, Guthikonda B (2012) Vagal nerve stimulation for the treatment of medically refractory epilepsy: a review of the current literature. Neurosurg Focus 32(3):E 12

    Article  Google Scholar 

  6. Cramer JA (2001) Exploration of changes in health-related quality of life after 3 months of vagus nerve stimulation. Epilepsy Behav 2:460–465

    Article  PubMed  Google Scholar 

  7. DeGiorgio CM, Schachter SC, Handforth A, Salinsky M, Thompson J, Uthman B, Reed R, Collins S, Tecoma E, Morris GL, Vaughn B, Naritoku DK, Henry T, Labar D, Gilmartin R, Labiner D, Osorio I, Ristanovic R, Jones J, Murphy J, Ney G, Wheless J, Lewis P, Heck C (2000) Prospective long-term study of vagus nerve stimulation for the treatment of refractory seizures. Epilepsia 41:1195–1200

    Article  CAS  PubMed  Google Scholar 

  8. De Herdt V, Boon P, Ceulemans B, Hauman H, Lagae L, Legros B, Sadzot B, Van Bogaert P, van Rijckevorsel K, Verhelst H, Vonck K (2007) Vagus nerve stimulation for refractory epilepsy: a Belgian multi-center study. Eur J Paediatr Neurol 11(5):261–269

    Article  PubMed  Google Scholar 

  9. Devinsky O, Pacia S (1993) Epilepsy surgery. Neurol Clin 11(4):951–971

    CAS  PubMed  Google Scholar 

  10. Duchowny MS, Harvey AS, Sperling MR, Williamson PD (2007) Indications and criteria for surgical intervention. In: Engel J Jr, Pedley TA (eds) Epilepsy: a comprehensive textbook, 2nd edn. Lippincott Williams & Wilkins, Philadelphia, pp 1751–1759

    Google Scholar 

  11. Elliott RE, Rodgers SD, Bassani L, Morsi A, Geller EB, Carlson C, Devinsky O, Doyle WK (2011) Vagus nerve stimulation for children with treatment-resistant epilepsy: a consecutive series of 141 cases. J Neurosurg Pediatr 7(5):491–500

    Article  PubMed  Google Scholar 

  12. Elliott RE, Morsi A, Kalhorn SP, Marcus J, Sellin J, Kang M, Silverberg A, Rivera E, Geller E, Carlson C, Devinsky O, Doyle WK (2011) Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy: long-term outcomes and predictors of response. Epilepsy Behav 20(1):57–63

    Article  PubMed  Google Scholar 

  13. Elliott RE, Morsi A, Tanweer O, Grobelny B, Geller E, Carlson C, Devinsky O, Doyle WK (2011) Efficacy of vagus nerve stimulation over time: review of 65 consecutive patients with treatment-resistant epilepsy treated with VNS >10 years. Epilepsy Behav 20:478–483

    Article  PubMed  Google Scholar 

  14. Engel J Jr (1996) Surgery for seizures. N Engl J Med 334(10):647–652

    Article  PubMed  Google Scholar 

  15. Ergene E, Behr PK, Shih JJ (2001) Quality-of-life assessment in patients treated with vagus nerve stimulation. Epilepsy Behav 2:284–287

    Article  PubMed  Google Scholar 

  16. Galbarriatu L, Pomposo I, Aurrecoechea J, Marinas A, Agúndez M, Gómez JC, Acera MA, Martínez MJ, Valle E, Maestro I, Mateos B, Cabrera A, Fernández J, Iturri F, Garamendi I (2015) Vagus nerve stimulation therapy for treatment-resistant epilepsy: a 15-year experience at a single institution. Clin Neurol Neurosurg 137:89–93

    Article  CAS  PubMed  Google Scholar 

  17. Garcia-March G, Sanchez-Ledesma MJ, Broseta J (2008) Vagus nerve stimulation for the treatment of refractory epilepsy. State of the art. Neurocirugia (Astur) 19(5):416–426

    Article  CAS  Google Scholar 

  18. Handforth A, DeGiorgio CM, Schachter SC, Uthman BM, Naritoku DK, Tecoma ES, Henry TR, Collins SD, Vaughn BV, Gilmartin RC, Labar DR, Morris GL, Salinsky MC, Osorio I, Ristanovic RK, Labiner DM, Jones JC, Murphy JV, Ney GC, Wheless JW (1998) Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurology 51:48–55

    Article  CAS  PubMed  Google Scholar 

  19. Kostov H, Larsson PG, Roste GK (2007) Is vagus nerve stimulation a treatment option for patients with drug-resistant idiopathic generalized epilepsy? Acta Neurol Scand Suppl 187:55–58

    Article  CAS  PubMed  Google Scholar 

  20. Kwan P, Brodie MJ (2000) Early identification of refractory epilepsy. N Engl J Med 342(5):314–319

    Article  CAS  PubMed  Google Scholar 

  21. Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Hauser WA, Mathern G, Moshé SL, Perucca E, Wiebe S, French J (2010) Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 51(6):1069–1077

    Article  CAS  PubMed  Google Scholar 

  22. Lancman G, Virk M, Shao H, Mazumdar M, Greenfield JP, Weinstein S, Schwartz TH (2013) Vagus nerve stimulation vs. corpus callosotomy in the treatment of Lennox–Gastaut syndrome: a meta-analysis. Seizure 22(1):3–8

    Article  PubMed  Google Scholar 

  23. Morris GL, Mueller WM (1999) Long-term treatment with vagus nerve stimulation in patients with refractory epilepsy. The Vagus Nerve Stimulation Study Group E0I-E05. Neurology 53:1731–1735

    Article  PubMed  Google Scholar 

  24. Ng M, Devinsky O (2004) Vagus nerve stimulation for refractory idiopathic generalised epilepsy. Seizure 13:176–178

    Article  PubMed  Google Scholar 

  25. Parain D, Penniello MJ, Berquen P, Delangre T, Billard C, Murphy JV (2001) Vagal nerve stimulation in tuberous sclerosis complex patients. Pediatr Neurol 25(3):213–216

    Article  CAS  PubMed  Google Scholar 

  26. Porter R (1991) Epilepsy: prevalence, classification, diagnosis, and prognosis. In: Apuzzo MLJ (ed) Neurosurgical aspects of epilepsy. AANS, Park Ridge, pp 17–26

    Google Scholar 

  27. Tellez-Zenteno JF, Dhar R, Wiebe S (2005) Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain 128:1188–1198

    Article  PubMed  Google Scholar 

  28. Yamamoto T (2015) Vagus nerve stimulation therapy: indications, programing, and outcomes. Neurol Med Chir (Tokyo) 55(5):407–415

    Article  Google Scholar 

Download references

Conflict of Interest Statement

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R. Morace .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this paper

Cite this paper

Morace, R. et al. (2017). Vagal Nerve Stimulation for Drug-Resistant Epilepsy: Adverse Events and Outcome in a Series of Patients with Long-Term Follow-Up. In: Visocchi, M., Mehdorn, H.M., Katayama, Y., von Wild, K.R.H. (eds) Trends in Reconstructive Neurosurgery. Acta Neurochirurgica Supplement, vol 124. Springer, Cham. https://doi.org/10.1007/978-3-319-39546-3_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-39546-3_8

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-39545-6

  • Online ISBN: 978-3-319-39546-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics