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PACAP Signaling in Neuroprotection

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Pituitary Adenylate Cyclase Activating Polypeptide — PACAP

Part of the book series: Current Topics in Neurotoxicity ((Current Topics Neurotoxicity,volume 11))

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Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) exerts its neuroprotective effects mainly through its PACAP-preferring receptor PAC1. Upon binding to this receptor and stimulation of adenylate cyclase and phospholipase C through G proteins, PACAP activates multiple signaling cascades to promote its neuroprotective actions. The neuroprotective function of PACAP has been demonstrated in vitro and in vivo during neuronal differentiation, in neurodegenerative disease models, and after administration of toxic molecules. PACAP neuroprotective activity mainly involves different kinases including protein kinase A, extracellular regulated kinase, AMP kinase, or phosphatidylinositol-3′OH kinase which in turn activate several transcription factors such as the cAMP response element-binding protein, activating transcription factor 2, or nuclear factor kappa B to regulate different genes involved in cell survival. PACAP also induces neuroprotection via indirect pathways involving other neurotrophic factors, cytokines or chemokines. These different pathways activated by PACAP converge to inhibit caspases and therefore apoptosis during neurodevelopment or in various pathological conditions of the central nervous system.

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  1. INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, University of Rouen, Mont-Saint-Aignan, 76821, France

    Destiny-Love Manecka, Loubna Boukhzar, Anthony Falluel-Morel, Isabelle Lihrmann & Youssef Anouar

  2. Normandy University, Caen, France

    Destiny-Love Manecka, Loubna Boukhzar, Anthony Falluel-Morel, Isabelle Lihrmann & Youssef Anouar

Authors
  1. Destiny-Love Manecka
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  2. Loubna Boukhzar
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  3. Anthony Falluel-Morel
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  4. Isabelle Lihrmann
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  5. Youssef Anouar
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Corresponding author

Correspondence to Youssef Anouar .

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Editors and Affiliations

  1. Department of Anatomy MTA-PTE “Lendulet” PACAP Research Team, University of Pecs, Pecs, Hungary

    Dora Reglodi

  2. Department of Anatomy MTA-PTE “Lendulet” PACAP Research Team, University of Pecs, Pecs, Hungary

    Andrea Tamas

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© 2016 Springer International Publishing Switzerland

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Manecka, DL., Boukhzar, L., Falluel-Morel, A., Lihrmann, I., Anouar, Y. (2016). PACAP Signaling in Neuroprotection. In: Reglodi, D., Tamas, A. (eds) Pituitary Adenylate Cyclase Activating Polypeptide — PACAP. Current Topics in Neurotoxicity, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-319-35135-3_32

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