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Influence of Thyroid Hormones on Tendon Homeostasis

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Metabolic Influences on Risk for Tendon Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 920))

Abstract

Tendinopathies have a multifactorial etiology driven by extrinsic and intrinsic factors. Recent studies have elucidated the importance of thyroid hormones in the alteration of tendons homeostasis and in the failure of tendon healing after injury. The effects of thyroid hormones are mediated by receptors (TR)-α and –β that seem to be ubiquitous. In particular, T3 and T4 play an antiapoptotic role on tenocytes, causing an increase in vital tenocytes isolated from tendons in vitro and a reduction of apoptotic ones; they are also able to influence extra cellular matrix proteins secretion in vitro from tenocytes, enhancing collagen production. From a clinical point of view, disorders of thyroid function have been investigated only for rotator cuff calcific tendinopathy and tears. In this complex scenario, further research is needed to clarify the role of thyroid hormones on the onset of tendinopathies.

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References

  1. Giai VA, De Cupis M, Spoliti M, Oliva F (2013) Clinical and biological aspects of rotator cuff tears. Muscles Ligaments Tendons J 3(2):70–9

    Google Scholar 

  2. Oliva F, Piccirilli E, Berardi AC, Frizziero A, Tarantino U, Maffulli N (2015) Hormones and tendinopathies: the current evidence. Br Med Bull 117(1):39–58

    Article  Google Scholar 

  3. Oliva F, Giai Via A, Maffulli N (2012) Physiopathology of intratendinous calcific deposition. BMC Med 10:95

    Article  PubMed  PubMed Central  Google Scholar 

  4. Duncan Bassett JH, Harvey CB, Williams GR (2003) Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions. Mol Cell Endocrinol 213(1):1–11

    Article  Google Scholar 

  5. Oetting A, Yen PM (2007) New insights into thyroid hormone action. Best Pract Res Clin Endocrinol Metab 21(2):193–208

    Article  CAS  PubMed  Google Scholar 

  6. Brent GA (2000) Tissue-specific actions of thyroid hormone: insights from animal models. Rev Endocr Metab Disord 1(1–2):27–33

    Article  CAS  PubMed  Google Scholar 

  7. Berardi AC, Oliva F (2014) How thyroid hormones modify tendons, Metabolic diseases and tendinopathies book, Fondazione Ibsa, IV forum 21 June 2014, Lugano.

    Google Scholar 

  8. Oliva F, Osti L, Padulo J, Maffulli N (2014) Epidemiology of the rotator cuff tears: a new incidence related to thyroid disease, muscles. Ligaments Tendons J 4(3):309–314

    Google Scholar 

  9. Harvie P, Pollard TC, Carr AJ (2007) Calcific tendinitis: natural history and association with endocrine disorders. J Shoulder Elbow Surg 16(2):169–173

    Article  PubMed  Google Scholar 

  10. Flamant F, Samarut J (2003) Thyroid hormone receptor: lessons from knock-out and knock-in mice. Trends Endoc Metab 14:85–90

    Article  CAS  Google Scholar 

  11. Oliva F, Berardi AC, Misiti S, Falzacappa CV, Iaconeand A, Maffulli N (2013) Thyroid hormones enhance growth and counteract apoptosis in human tenocytes isolated from rotator cuff tendons. Cell Death Dis 4, e705

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Tresoldi I, Oliva F, Benvenuto M, Fantini M, Masuelli L, Bei R, Modesti A (2013) Tendon’s ultrastructure. Muscles Ligaments Tendons J 3(1):2–6

    PubMed  PubMed Central  Google Scholar 

  13. Berardi AC, Oliva F, Berardocco M, la Rovere M, Accorsi P, Maffulli N (2014) Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes, muscles. Ligaments Tendons J 4(3):285–291

    Google Scholar 

  14. Varga F, Rumpler M, Zoehrer R, Turecek C, Spitzer S, Thaler R, Paschalis EP, Klaushofer K (2010) T3 affects expression of collagen I and collagen cross-linking in bone cell cultures. Biochem Biophys Res Commun 402(2–3):180–185

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Murata Y, Refetoff S, Horwitz AL, Smith TJ (1983) Hormonal regulation of glycosaminoglycan accumulation in fibroblasts from patients with resistance to thyroid hormone. J Clin Endocrinol Metab 57(6):1233–9

    Article  CAS  PubMed  Google Scholar 

  16. Purnell DC, Daly DD, Lipscomb PR (1961) Carpal-tunnel syndrome associated with myxedema. Arch Intern Med 108:751–756

    Article  CAS  PubMed  Google Scholar 

  17. Oliva F, Piccirilli E, Berardi AC, Frizziero A, Tarantino U, Maffulli N (2016) Hormones and tendinopathies: the current evidence. Br Med Bull 117(1):39–58. doi:10.1093/bmb/pii:ldv054

    Article  PubMed  Google Scholar 

  18. Connell D, Datir A, Alyas F, Curtis M (2009) Treatment of lateral epicondylitis using skin-derived tenocyte-like cells. Br J Sports Med 43:293–298

    Article  CAS  PubMed  Google Scholar 

  19. Clarke AW, Alyas F, Morris T, Robertson CJ, Bell J, Connell DA (2011) Skin-derived tenocyte-like cells for the treatment of patellar tendinopathy. Am J Sports Med 39(3):614–23, Epub 2010 Dec 7

    Article  PubMed  Google Scholar 

  20. Williams AJ, O'Shea PJ, Williams GR (2007) Complex interactions between thyroid hormone and fibroblast growth factor signalling. Curr Opin Endocrinol Diabetes Obes 14(5):410–5

    Article  CAS  PubMed  Google Scholar 

  21. Mackley JR, Ando J, Herzyk P, Winder SJ (2006) Phenotypic responses to mechanical stress in fibroblasts from tendon, cornea and skin. Biochem J 396(2):307–16

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Benson RT, McDonnell SM, Knowles HJ, Rees JL, Carr AJ, Hulley PA (2010) Tendinopathy and tears of the rotator cuff are associated with hypoxia and apoptosis. J Bone Joint Surg (Br) 92(3):448–453

    Article  CAS  Google Scholar 

  23. Oliva F, Via AG, Maffulli N (2011) Calcific tendinopathy of the rotator cuff tendons. Sports Med Arthrosc 19(3):237–43

    Article  PubMed  Google Scholar 

  24. Anwar S, Gibofsky A (2010) Musculoskeletal manifestations of thyroid disease. Rheum Dis Clin North Am 36(4):637–46

    Article  PubMed  Google Scholar 

  25. Oliva F, Barisani D, Grasso A, Maffulli N (2011) Gene expression analysis in calcific tendinopathy of the rotator cuff. Eur Cell Mater 21:548–57

    CAS  PubMed  Google Scholar 

  26. Knopp WD, Bohm ME, McCoy JC (1997) Hypothyroidism presenting as tendinitis. Phys Sportsmed 25:47–55

    Article  CAS  PubMed  Google Scholar 

  27. Oliva F, Berardi AC, Misiti S, Maffulli N (2013) Thyroid hormones and tendon: current views and future perspectives concise review. Muscles Ligaments Tendons J 3(3):2013

    Google Scholar 

  28. Linee Guida IS, Mu LT (2014) Rotture della cuffia dei rotator, Percorsi Editoriali Carocci Publisher, Francesco Oliva Editor, Roma, Italy, pp 1–239. ISBN 978-88-430-7683-3

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Orthopaedics and Traumatology, University of Rome “Tor Vergata”, Rome, Italy

    Francesco Oliva, Eleonora Piccirilli & Umberto Tarantino

  2. UOC Immunohematology and Transfusion Medicine Laboratories, Laboratory of Stem Cells, Spirito Santo Hospital, Pescara, Italy

    Anna C. Berardi

  3. Centre for Sports and Exercise Medicine, Queen Mary University of London Barts and The London School of Medicine and Dentistry, Mile End Hospital, London, UK

    Nicola Maffulli

  4. Head of Department of Physical and Rehabilitation Medicine, University of Salerno, Salerno, Italy

    Nicola Maffulli

Authors
  1. Francesco Oliva
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  2. Eleonora Piccirilli
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  3. Anna C. Berardi
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  4. Umberto Tarantino
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  5. Nicola Maffulli
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Corresponding author

Correspondence to Francesco Oliva .

Editor information

Editors and Affiliations

  1. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

    Paul W. Ackermann

  2. McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada

    David A. Hart

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Oliva, F., Piccirilli, E., Berardi, A.C., Tarantino, U., Maffulli, N. (2016). Influence of Thyroid Hormones on Tendon Homeostasis. In: Ackermann, P., Hart, D. (eds) Metabolic Influences on Risk for Tendon Disorders. Advances in Experimental Medicine and Biology, vol 920. Springer, Cham. https://doi.org/10.1007/978-3-319-33943-6_12

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