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Non-covalent Functionalization of Carbon Nanotubes for Efficient Gene Delivery

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Nanophysics, Nanophotonics, Surface Studies, and Applications

Part of the book series: Springer Proceedings in Physics ((SPPHY,volume 183))

Abstract

During recent decades there is a growing need in advanced nanotechnology-based gene delivery techniques for biology, biotechnology, and biomedicine since conventional genetic transformation techniques are exhausting their potentialities in front of recent major challenges in respective fields. There exists a wide variety of nanostructures of different properties and compositions that are considered suitable for this aim. Among them, carbon nanotubes (CNTs) are viewed to pose promising platform for the development of advanced gene delivery methods due to their acceptable biocompatibility levels, needlelike structure, and high surface area responsible for extensive modification and molecular cargo binding. In this review the background and recent achievements of using CNTs as gene delivery vehicles are discussed. The applicability of covalent and non-covalent CNT functionalization approaches for the design of favorable CNT interfaces useful in biology is elucidated as well as basic mechanisms of these processes are outlined. In contrast to widely exploited covalent functionalization, the potential of non-covalent surface modification of CNTs is considered.

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Authors and Affiliations

  1. Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Osipovskogo Str., 2a, Kyiv, 04123, Ukraine

    Olga Burlaka, Alla Yemets, Yaroslav Pirko & Yaroslav Blume

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  1. Olga Burlaka
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  2. Alla Yemets
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  3. Yaroslav Pirko
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  4. Yaroslav Blume
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Correspondence to Yaroslav Blume .

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Editors and Affiliations

  1. Institute of Physics of National Academy of Sciences of Ukraine, Kiev, Ukraine

    Olena Fesenko

  2. Institute of Physics of National Academy of Sciences of Ukraine, Kiev, Ukraine

    Leonid Yatsenko

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Burlaka, O., Yemets, A., Pirko, Y., Blume, Y. (2016). Non-covalent Functionalization of Carbon Nanotubes for Efficient Gene Delivery. In: Fesenko, O., Yatsenko, L. (eds) Nanophysics, Nanophotonics, Surface Studies, and Applications. Springer Proceedings in Physics, vol 183. Springer, Cham. https://doi.org/10.1007/978-3-319-30737-4_30

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