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Small Signaling Molecules and CO-Releasing Molecules (CORMs) for the Modulation of the Cellular Redox Metabolism

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Redox-Active Therapeutics

Abstract

Together with nitric oxide (NO) and hydrogen sulfide (H2S), carbon monoxide (CO) belongs to a class of small endogenously produced signaling molecules which has gained steadily increasing attention in the biomedical community over the last two decades due to their fascinating properties and potential therapeutic applications in human medicine. The present review compares the chemical properties of these three signaling molecules as well as their endogenous enzymatic production and then critically reviews molecular delivery systems for carbon monoxide, the so-called CO-releasing molecules (CORMs). Different trigger mechanisms to initiate the liberation of carbon monoxide from molecular carrier systems are discussed and assessed for their utility in biological studies.

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Acknowledgments

P.S. thanks the Alexander-von-Humboldt Foundation for a postdoctoral fellowship.

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Authors and Affiliations

  1. Department of Chemistry, Curtin University, Bentley, WA, Australia

    Peter V. Simpson

  2. Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Würzburg, D-97074, Germany

    Ulrich Schatzschneider

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  1. Peter V. Simpson
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  2. Ulrich Schatzschneider
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Correspondence to Ulrich Schatzschneider .

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  1. Duke University School of Medicine, Durham, North Carolina, USA

    Ines Batinić-Haberle

  2. Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil

    Júlio S. Rebouças

  3. Duke University School of Medicine, Durham, North Carolina, USA

    Ivan Spasojević

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Simpson, P.V., Schatzschneider, U. (2016). Small Signaling Molecules and CO-Releasing Molecules (CORMs) for the Modulation of the Cellular Redox Metabolism. In: Batinić-Haberle, I., Rebouças, J., Spasojević, I. (eds) Redox-Active Therapeutics. Oxidative Stress in Applied Basic Research and Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-30705-3_13

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