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Historical Overview of Store-Operated Ca2+ Entry

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Calcium Entry Pathways in Non-excitable Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 898))

Abstract

Calcium influx is an essential mechanism for the activation of cellular functions both in excitable and non-excitable cells. In non-excitable cells, activation of phospholipase C by occupation of G protein-coupled receptors leads to the generation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), which, in turn, initiate two Ca2+ entry pathways: Ca2+ release from intracellular Ca2+ stores, signaled by IP3, leads to the activation of store-operated Ca2+ entry (SOCE); on the other hand, DAG activates a distinct second messenger-operated pathway. SOCE is regulated by the filling state of the intracellular calcium stores. The search for the molecular components of SOCE has identified the stromal interaction molecule 1 (STIM1) as the Ca2+ sensor in the endoplasmic reticulum and Orai1 as a store-operated channel (SOC) subunit. Furthermore, a number of reports have revealed that several members of the TRPC family of channels also take part of the SOC macromolecular complex. This introductory chapter summarizes the early pieces of evidence that led to the concept of SOCE and the components of the store-operated signaling pathway.

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Acknowledgments

This work was supported by MINECO (Grant BFU2013-45564-C2-1-P) and Gobierno de Extremadura-FEDER (GR15029). JJL and LA are supported by Juan de la Cierva Program (JCI-2012-12934) and MINECO fellowship BES-2011-043356, respectively.

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  1. Department of Physiology (Cell Physiology Research Group), University of Extremadura, Av. Universidad s/n, 10003, Cáceres, Spain

    Letizia Albarran, Jose J. Lopez & Ginés M. Salido

  2. Departamento de Fisiología, University of Extremadura, Cáceres, Spain

    Juan A. Rosado

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  1. Letizia Albarran
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  2. Jose J. Lopez
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    Juan A. Rosado

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Albarran, L., Lopez, J.J., Salido, G.M., Rosado, J.A. (2016). Historical Overview of Store-Operated Ca2+ Entry. In: Rosado, J. (eds) Calcium Entry Pathways in Non-excitable Cells. Advances in Experimental Medicine and Biology, vol 898. Springer, Cham. https://doi.org/10.1007/978-3-319-26974-0_1

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