Abstract
Suicide constitutes a serious medical and social problem. There are several risk factors for suicide including history of mental disorders, alcohol and substance abuse, impulsive or aggressive tendencies, family history of suicide, family history of child maltreatment, previous suicide attempts, feelings of hopelessness, cultural and religious beliefs, and physical illness, in particular chronic pain. Up to date, there are no animal models of suicide mainly because there is no instance of suicide among animals. Indeed suicide occurs almost exclusively in humans giving the link to two important aspects of the human being: (1) the self-consciousness and (2) the psychological suffering. However, in experimental animals we can model several of the main risk factors for suicidal behavior. In this chapter we will thus describe the main animal paradigms of mood disorders, aggression, impulsivity, and drug abuse/dependence. Moreover, we examine the in-vivo electrophysiology technique which allows the study of the neural activity of the different neurotransmitters implicated in suicide. The combination of behavioral pharmacology and electrophysiology is currently a gold standard for the investigation of the neurobiology of mental illness and has allowed answering clinically relevant questions and developing novel and efficacious treatments in psychiatry. This approach may thus have great potential also in the field of suicide allowing to increasing our understanding of the neurobiological basis of suicide. However, to develop novel pharmacological strategies to prevent suicide attempts, more translational research in humans is needed to understand the link between depression, impulsivity, self-consciousness, and psychological suffering.
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References
Bambico FR, Duranti A, Tontini A, Tarzia G, Gobbi G (2009) Endocannabinoids in the treatment of mood disorders: evidence from animal models. Curr Pharm Des 15(14):1623–1646
Bambico FR, Cassano T, Dominguez-Lopez S, Katz N, Walker CD, Piomelli D, Gobbi G (2010) Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. Neuropsychopharmacology 35(10):2083–2100
Bonino S (2008) Vivre la maladie: ces liens qui me rattachent à la vie. De Boeck Supérieur, Bruxelles
Borges G, Walters EE, Kessler RC (2000) Associations of substance use, abuse, and dependence with subsequent suicidal behavior. Am J Epidemiol 151(8):781–789
Bryan CJ, Rudd MD (2006) Advances in the assessment of suicide risk. J Clin Psychol 62(2):185–200
Carballo JJ, Akamnonu CP, Oquendo MA (2008) Neurobiology of suicidal behavior. An integration of biological and clinical findings. Arch Suicide Res 12(2):93–110
Carli M, Robbins TW, Evenden JL, Everitt BJ (1983) Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behav Brain Res 9(3):361–380
Comai S, Tau M, Pavlovic Z, Gobbi G (2012) The psychopharmacology of aggressive behavior: a translational approach: part 2: clinical studies using atypical antipsychotics, anticonvulsants, and lithium. J Clin Psychopharmacol 32(2):237–260
Conner KR, Swogger MT, Houston RJ (2009) A test of the reactive aggression-suicidal behavior hypothesis: is there a case for proactive aggression? J Abnorm Psychol 118(1):235–240
Cryan JF, Holmes A (2005) The ascent of mouse: advances in modelling human depression and anxiety. Nat Rev Drug Discov 4(9):775–790
Cryan JF, Mombereau C, Vassout A (2005) The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev 29(4):571–625
Descarries L, Watkins KC, Garcia S, Beaudet A (1982) The serotonin neurons in nucleus raphe dorsalis of adult rat: a light and electron microscope radioautographic study. J Comp Neurol 207(3):239–254
Dominguez-Lopez S, Howell R, Gobbi G (2012) Characterization of serotonin neurotransmission in knockout mice: implications for major depression. Rev Neurosci 23(4):429–443
Dulawa SC, Hen R (2005) Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test. Neurosci Biobehav Rev 29(4–5):771–783
Eagle DM, Robbins TW (2003) Inhibitory control in rats performing a stop-signal reaction-time task: effects of lesions of the medial striatum and d-amphetamine. Behav Neurosci 117(6):1302–1317
Emmett-Oglesby M, Peltier R, Depoortere R, Pickering C, Hooper M, Gong Y, Lane J (1993) Tolerance to self-administration of cocaine in rats: time course and dose-response determination using a multi-dose method. Drug Alcohol Depend 32(3):247–256
Ernst C, Lalovic A, Lesage A, Seguin M, Tousignant M, Turecki G (2004) Suicide and no axis I psychopathology. BMC Psychiatry 4:7
Harris EC, Barraclough B (1997) Suicide as an outcome for mental disorders. A meta-analysis. Br J Psychiatry 170(3):205–228
Henriksson MM, Aro HM, Kuoppasalmi KI, Jouko K (1993) Mental disorders and comorbidity in suicide. Am J Psychiatry 1(50):935–940
Hustvedt S (2013) Suicide and the drama of self-consciousness. Suicidology Online 4:105–113
Lesage AD, Boyer R, Grunberg F, Vanier C, Morissette R, Menard-Buteau C, Loyer M (1994) Suicide and mental disorders: a case-control study of young men. Am J Psychiatry 151(7):1063–1068
Lipszyc J, Schachar R (2010) Inhibitory control and psychopathology: a meta-analysis of studies using the stop signal task. J Int Neuropsychol Soc 16(6):1064–1076
Mann JJ, Currier D (2007) A review of prospective studies of biologic predictors of suicidal behavior in mood disorders. Arch Suicide Res 11(1):3–16
Mann JJ, Waternaux C, Haas GL, Malone KM (1999) Toward a clinical model of suicidal behavior in psychiatric patients. Am J Psychiatry 156(2):181–189
Mann JJ, Brent DA, Arango V (2001) The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system. Neuropsychopharmacology 24(5):467–477
Mar AC, Robbins TW (2007) Delay discounting and impulsive choice in the rat. Curr Protoc Neurosci 8.22:1–18
McAllister MK, Roitberg BD (1987) Adaptive suicidal behaviour in pea aphids. Nature 328(6133):797–799
Miczek KA (1979) A new test for aggression in rats without aversive stimulation: differential effects of d-amphetamine and cocaine. Psychopharmacology 60(3):253–259
Olivier B, Mos J (1986) A female aggression paradigm for use in psychopharmacology: maternal agonistic behaviour in rats. Cross-disciplinary studies on aggression. University of Seville Press, Seville, pp 73–111
Pandey GN (2013) Biological basis of suicide and suicidal behavior. Bipolar Disord 15(5):524–541
Porsolt RD, Anton G, Blavet N, Jalfre M (1978) Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47(4):379–391
Preti A (2011) Do animals commit suicide? Does it matter? Crisis 32(1):1–4
Romanov K, Hatakka M, Keskinen E, Laaksonen H, Kaprio J, Rose RJ, Koskenvuo M (1994) Self-reported hostility and suicidal acts, accidents, and accidental deaths: a prospective study of 21,443 adults aged 25 to 59. Psychosom Med 56(4):328–336
Rubio DM, Schoenbaum EE, Lee LS, Schteingart DE, Marantz PR, Anderson KE, Platt LD, Baez A, Esposito K (2010) Defining translational research: implications for training. Acad Med 85(3):470–475
Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301(5634):805–809
Seligman ME, Beagley G (1975) Learned helplessness in the rat. J Comp Physiol Psychol 88(2):534
Seligman ME, Maier SF (1967) Failure to escape traumatic shock. J Exp Psychol 74(1):1
Shaffer D, Fisher P (1981) The epidemiology of suicide in children and young adolescents. J Am Acad Child Psychiatry 20(3):545–565
Shneidman ES (1993) Suicide as psychache: a clinical approach to self-destructive behavior. Jason Aronson, Northvale, New Jersey
Spanagel R (2003) Alcohol addiction research: from animal models to clinics. Best Pract Res Clin Gastroenterol 17(4):507–518
Tulogdi A, Biro L, Barsvari B, Stankovic M, Haller J, Toth M (2015) Neural mechanisms of predatory aggression in rats – implications for abnormal intraspecific aggression. Behav Brain Res 283:108–115
Willner P (2005) Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52(2):90–110
Willner P, Muscat R, Papp M (1992) Chronic mild stress-induced anhedonia: a realistic animal model of depression. Neurosci Biobehav Rev 16(4):525–534
World Health Organization (2014) Preventing suicide: a global imperative
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Comai, S., Gobbi, G. (2016). Translational Research in Suicide: Is It Possible to Study Suicide in Animal Models?. In: Courtet, P. (eds) Understanding Suicide. Springer, Cham. https://doi.org/10.1007/978-3-319-26282-6_14
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DOI: https://doi.org/10.1007/978-3-319-26282-6_14
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