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Microbiome to Brain: Unravelling the Multidirectional Axes of Communication

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Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health

Part of the book series: Advances in Experimental Medicine and Biology ((MICENDO,volume 874))

Abstract

The gut microbiome plays a crucial role in host physiology. Disruption of its community structure and function can have wide-ranging effects making it critical to understand exactly how the interactive dialogue between the host and its microbiota is regulated to maintain homeostasis. An array of multidirectional signalling molecules is clearly involved in the host-microbiome communication. This interactive signalling not only impacts the gastrointestinal tract, where the majority of microbiota resides, but also extends to affect other host systems including the brain and liver as well as the microbiome itself. Understanding the mechanistic principles of this inter-kingdom signalling is fundamental to unravelling how our supraorganism function to maintain wellbeing, subsequently opening up new avenues for microbiome manipulation to favour desirable mental health outcome.

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Authors and Affiliations

  1. Microbial Physiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands

    Sahar El Aidy

  2. Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

    Roman Stilling, Timothy G. Dinan & John F. Cryan

  3. Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland

    Roman Stilling & John F. Cryan

  4. Department of Psychiatry, University College Cork, Cork, Ireland

    Timothy G. Dinan

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  1. Sahar El Aidy
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  2. Roman Stilling
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  3. Timothy G. Dinan
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  4. John F. Cryan
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Correspondence to John F. Cryan .

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  1. College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA

    Mark Lyte

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El Aidy, S., Stilling, R., Dinan, T.G., Cryan, J.F. (2016). Microbiome to Brain: Unravelling the Multidirectional Axes of Communication. In: Lyte, M. (eds) Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health. Advances in Experimental Medicine and Biology(), vol 874. Springer, Cham. https://doi.org/10.1007/978-3-319-20215-0_15

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