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Molecular HLA Typing

  • Chapter
Molecular Pathology in Clinical Practice

Abstract

This chapter describes the molecular genetics of the HLA genes, which reside within a genetic complex referred to as the major histocompatibility complex (MHC). The MHC contains the most polymorphic coding sequences in the human genome. HLA molecules provide the molecular basis for immunologic self-recognition, and many HLA genes encode proteins that function within immune regulatory networks.

This chapter describes (1) methods used for population genetic analyses including estimation of allele and haplotype frequencies and disease association studies; (2) the clinical utility of HLA typing for solid organ and bone marrow/hematopoietic cell transplantation, autoimmune diseases, and other disorders; (3) available assays for HLA typing, definition of typing resolution, and interpretation and reporting of test results.

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Author information

Authors and Affiliations

  1. Pathology and Laboratory Medicine, Penn Medicine, Philadelphia, PA, USA

    Malek Kamoun M.D., Ph.D.

  2. Center for Genetics, Children’s Hospital Oakland Research Institute, Oakland, CA, USA

    Jill A. Hollenbach Ph.D., M.P.H.

  3. Children’s Hospital Oakland Research Institute, Oakland, CA, USA

    Steven J. Mack Ph.D.

Authors
  1. Malek Kamoun M.D., Ph.D.
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  2. Jill A. Hollenbach Ph.D., M.P.H.
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  3. Steven J. Mack Ph.D.
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  4. Thomas M. Williams M.D.
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Corresponding author

Correspondence to Malek Kamoun M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Pathology and Laboratory Medicine, University of Vermont College of Medicine and University of Vermont Medical Center, Burlington, Vermont, USA

    Debra G.B. Leonard

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© 2016 Springer International Publishing Switzerland

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Kamoun, M., Hollenbach, J.A., Mack, S.J., Williams, T.M. (2016). Molecular HLA Typing. In: Leonard, D. (eds) Molecular Pathology in Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-19674-9_58

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  • DOI: https://doi.org/10.1007/978-3-319-19674-9_58

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19673-2

  • Online ISBN: 978-3-319-19674-9

  • eBook Packages: MedicineMedicine (R0)

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