Abstract
Globally, injectable pharmaceuticals and parenterals, implantable medical devices and similar therapeutic products are safety tested for endotoxin contamination using indicator reagents derived from the blood of horseshoe crabs. Tachypleus and Limulus Amoebocyte Lysate (TAL and LAL, respectively) are used in quality control laboratories for testing of raw materials, intermediates and final products to protect public health. As the demand for human and animal drugs and devices increases, so does the demand for TAL and LAL. In the United States, the harvesting of horseshoe crabs (Limulus polyphemus) is regulated and monitored. Harvesting limits have been exceeded in recent years and may lead to enforcement of harvesting limits to the American LAL industry. Throughout most of Asia, the harvesting of horseshoe crabs is poorly regulated and unmonitored. All indicators point to a declining population. If the Tachypleus population cannot support TAL production for the Asia and Pacific pharmaceutical and medical device industries, companies will entirely depend on LAL for testing. The already limited LAL supply is not sufficient to support this increased global demand and will likely result in increased cost and constrain the availability of pharmaceutical and medical device products. As consumers of horseshoe crab-based products, the pharmaceutical and medical device industries can act to help protect horseshoe crab species and, in turn, protect the long-term availability of endotoxin testing products. Global supply chain initiatives that integrate social and environmental considerations into the qualification and choice of vendors, use of best practices for TAL and LAL production, and developing alternative testing methods will promote a more sustainable TAL/LAL industry that can include reduction of animal-based testing and global conservation of horseshoe crab species.
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References
ASMFC (Atlantic States Marine Fisheries Commission) (1998) Interstate fishery management plan for horseshoe crab. Atlantic States Marine Fisheries Commission, Fishery Management Report No 32. Washington, DC
ASMFC (Atlantic States Marine Fisheries Commission) (2013) Horseshoe crab stock assessment update 2.2
Botton ML, Ropes JW (1988) An indirect method for estimating longevity of the horseshoe crab (Limulus polyphemus) based on epifaunal slipper shells (Crepidula fornicata). J Shellfish Res 7:407–412
Botton ML, Loveland RE, Tiwari A (2003) Distribution, abundance, and survivorship of young-of-the-year in a commercially exploited population of horseshoe crabs Limulus polyphemus. Mar Ecol Prog Ser 265:175–184
Carmichael RH, Rutecki D, Valiela I (2003) Abundance and population structure of the Atlantic horseshoe crab Limulus polyphemus in Pleasant Bay, Cape Cod. Mar Ecol Prog Ser 246:225–239
Central Intelligence Agency (2014) China. In The World Factbook. https://www.cia.gov/library/publications/the-world-factbook/geos/br.html. Accessed Sept 2013
IMS (2012) Institute for Healthcare Informatics, IMS Market Prognosis, May 2012, Economic Intelligence Unit, Jan 2012
Leschen AS, Grady SP, Valiela I (2006) Fecundity and spawning of the Atlantic horseshoe crab, Limulus polyphemus, in Pleasant Bay, Cape Cod, Massachusetts, USA. Mar Ecol 27:54–65
Ropes JW (1961) Longevity of the horseshoe crab, Limulus polyphemus (L.). Trans Am Fish Soc 90:79–80
Rudloe A (1983) The effect of heavy bleeding on mortality of the horseshoe crab, Limulus polyphemus, in the natural environment. J Invertebr Pathol 42:167–176
Shuster CN Jr, Botton ML (1985) A contribution to the population biology of horseshoe crabs, Limulus polyphemus (L) in Delaware Bay. Estuaries 8:363–372
Visiongain (2010) Vaccines manufacturing technology and services: commercial prospects 2010–2025. The Global Vaccine Market, London, 2009–2025
Walls EA, Berkson J (2003) Effects of blood extraction on horseshoe crabs (Limulus polyphemus). Fish Bull 101:457–459
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Gauvry, G. (2015). Current Horseshoe Crab Harvesting Practices Cannot Support Global Demand for TAL/LAL: The Pharmaceutical and Medical Device Industries’ Role in the Sustainability of Horseshoe Crabs. In: Carmichael, R., Botton, M., Shin, P., Cheung, S. (eds) Changing Global Perspectives on Horseshoe Crab Biology, Conservation and Management. Springer, Cham. https://doi.org/10.1007/978-3-319-19542-1_27
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DOI: https://doi.org/10.1007/978-3-319-19542-1_27
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