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Src Family Kinases in Brain Edema After Acute Brain Injury

  • Chapter
Brain Edema XVI

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 121))

Abstract

Brain edema, the first stage of intracranial hypertension, has been associated with poor prognosis and increased mortality after acute brain injury such as ischemic stroke, intracranial hemorrhage (ICH), and traumatic brain injury (TBI). Acute brain injury often initiates release of many molecules, including glutamate, adenosine, thrombin, oxyhemoglobin, cytokines, reactive oxygen species (ROS), damage-associated molecular pattern molecules (DAMPs), and others. Most of these molecules activate Src family kinases (SFKs), a family of proto-oncogenic non-receptor tyrosine kinases, resulting in blood-brain barrier (BBB) disruption and brain edema at the acute stage after brain injury. However, SFKs also contribute to BBB self-repair and brain edema resolution in the chronic stage that follows brain injury. In this review, we summarize possible pathways through which SFKs are implicated in both brain edema formation and its eventual resolution.

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Disclosure

The authors acknowledge the support of AHA Beginning Grant-in-Aid 12BGIA12060381 (DZL) and National Institutes of Health grant RO1NS089901 (DZL).

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Authors and Affiliations

  1. Department of Neurology, M.I.N.D. Institute, University of California at Davis Medical Center, 2805 50th Street, Sacramento, CA, 95817, USA

    DaZhi Liu & Bradley P. Ander

  2. Department of Neurology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China

    Xiong Zhang & BeiLei Hu

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  1. DaZhi Liu
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  2. Xiong Zhang
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  4. Bradley P. Ander
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Correspondence to DaZhi Liu .

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Editors and Affiliations

  1. Department of Anesthesiology, Loma Linda University School of Medicine, Loma Linda, California, USA

    Richard L. Applegate

  2. Department of Neurosurgery, Soochow University The First Affiliated Hospital, Suzhou, Jiangsu, China

    Gang Chen

  3. Department of Neurosurgery, Third Military Medical University Southwest Hospital, Chongqing, China

    Hua Feng

  4. Dept.of Anesthesiology, Physiology and Neurosurgery, Loma Linda University School of Medicine, Loma Linda, California, USA

    John H. Zhang

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Liu, D., Zhang, X., Hu, B., Ander, B.P. (2016). Src Family Kinases in Brain Edema After Acute Brain Injury. In: Applegate, R., Chen, G., Feng, H., Zhang, J. (eds) Brain Edema XVI. Acta Neurochirurgica Supplement, vol 121. Springer, Cham. https://doi.org/10.1007/978-3-319-18497-5_33

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