Abstract
We explored the potential protective effects of tauroursodeoxycholic acid (TUDCA) on cone photoreceptor survival in a model of rapid retinal degeneration, the ß-Pde6rd1 (rd1) mouse model. We injected two strains of rd1 mice (B6.C3-Pde6brd1Hps4le/J and C57BL/6J-Pde6brd1−2/J mice) daily from postnatal day (P) 6 to P21 with TUDCA or vehicle. At P21, retinal function was evaluated with light-adapted electroretinography (ERG) and retinal structure was observed with plastic or frozen sections. TUDCA treatment partially preserved function and structure in B6.C3-Pde6brd1Hps4le/J mice but only partially preserved structure in C57BL/6J-Pde6brd1−2/J mice. Our results suggest a possible intervention for patients undergoing rapid retinal degeneration.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Boatright JH, Moring AG, McElroy C et al (2006) Tool from ancient pharmacopoeia prevents vision loss. Mol Vis 12:1706–1714
Boatright JH, Nickerson JM, Moring AG et al (2009) Bile acids in treatment of ocular disease. J Ocul Biol Dis Inform 2:149–159
Chang B, Hawes NL, Pardue MT et al (2007) Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene. Vis Res 47:624–633
Drack AV, Dumitrescu AV, Bhattarai S et al (2012) TUDCA slows retinal degeneration in two different mouse models of retinitis pigmentosa and prevents obesity in Bardet-Biedl syndrome type 1 mice. Invest Ophthalmol Vis Sci 53:100–106
Mocko JA, Kim M, Faulkner AE et al (2011) Effects of subretinal electrical stimulation in mer-KO mice. Invest Ophthalmol Vis Sci 52:4223–4230
Phillips MJ, Walker TA, Choi HY et al (2008) Tauroursodeoxycholic acid preservation of photoreceptor structure and function in the rd10 mouse through postnatal day 30. Invest Ophthalmol Vis Sci 49:2148–2155
Sancho-Pelluz J, Arango-Gonzalez B, Kustermann S et al (2008) Photoreceptor cell death mechanisms in inherited retinal degeneration. Mol Neurobiol 38:253–269
Acknowledgments
Grant support provided by NIH P30 EY006360, NIH R01 EY014026 and a grant from the Abraham J. & Phyllis Katz Foundation (to J.H.B.), Rehabilitation Research and Development Service Veterans Affairs Research Career Scientist Award (to M.T.P.), Atlanta VA Center of Excellence in Vision and Neurocognitive Rehabilitation, and Departmental Award from Research to Prevent Blindness.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this paper
Cite this paper
Lawson, E. et al. (2016). Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1 Mice. In: Bowes Rickman, C., LaVail, M., Anderson, R., Grimm, C., Hollyfield, J., Ash, J. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 854. Springer, Cham. https://doi.org/10.1007/978-3-319-17121-0_57
Download citation
DOI: https://doi.org/10.1007/978-3-319-17121-0_57
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-17120-3
Online ISBN: 978-3-319-17121-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)