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Mechanisms of Memory T Cell Activation and Effective Immunity

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Crossroads Between Innate and Adaptive Immunity V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 850))

Abstract

Effective immunization induces the development of populations of robust effector lymphocytes specific for the immunizing antigens. Amongst them are cytotoxic/CD8+T lymphocytes, which few will further differentiate into long-lived memory cells persisting in the host and exhibiting improved functional characteristics. The current model is that such memory cells can confer rapid host protection upon cognate antigen-mediated activation and direct killing of infected cells. In this chapter, we discuss work from our group and others that highlight the contribution of inflammatory cytokines to memory CD8+ T cell activation and of cytolysis-independent mechanisms of host protection.

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA

    Grégoire Lauvau & Saïdi M’Homa Soudja

Authors
  1. Grégoire Lauvau
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  2. Saïdi M’Homa Soudja
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Corresponding author

Correspondence to Grégoire Lauvau .

Editor information

Editors and Affiliations

  1. Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, La Jolla, USA

    Stephen P. Schoenberger

  2. Department Microbiology & Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Peter D. Katsikis

  3. Yerkes National Primate Research Center, Emory University Emory Vaccine Center &, Atlanta, Georgia, USA

    Bali Pulendran

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© 2015 Springer International Publishing Switzerland

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Lauvau, G., Soudja, S. (2015). Mechanisms of Memory T Cell Activation and Effective Immunity. In: Schoenberger, S., Katsikis, P., Pulendran, B. (eds) Crossroads Between Innate and Adaptive Immunity V. Advances in Experimental Medicine and Biology, vol 850. Springer, Cham. https://doi.org/10.1007/978-3-319-15774-0_6

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