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Modeling Prolactin Actions in Breast Cancer In Vivo: Insights from the NRL-PRL Mouse

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Recent Advances in Prolactin Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 846))

Abstract

Elevated exposure to prolactin (PRL) is epidemiologically associated with an increased risk of aggressive ER+ breast cancer. To understand the underlying mechanisms and crosstalk with other oncogenic factors, we developed the NRL-PRL mouse. In this model, mammary expression of a rat prolactin transgene raises local exposure to PRL without altering estrous cycling. Nulliparous females develop metastatic, histotypically diverse mammary carcinomas independent from ovarian steroids, and most are ER+. These characteristics resemble the human clinical disease, facilitating study of tumorigenesis, and identification of novel preventive and therapeutic approaches.

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Acknowledgements

The authors would like to thank Gail Loughridge for her assistance with the illustration, and are grateful to the National Cancer Institute of the National Institutes of Health, the Congressionally Directed Medical Research Program, the Department of Comparative Biosciences at the School of Veterinary Medicine, and Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, for support of these studies.

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Authors and Affiliations

  1. Department of Comparative Biosciences, University of Wisconsin–Madison, Madison, WI, USA

    Kathleen A. O’Leary, Michael P. Shea & Linda A. Schuler

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  1. Kathleen A. O’Leary
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  2. Michael P. Shea
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  3. Linda A. Schuler
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Correspondence to Kathleen A. O’Leary .

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  1. Department of Biological Sciences, University of Toledo, Toledo, Ohio, USA

    Maria Diakonova, PhD

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O’Leary, K., Shea, M., Schuler, L. (2015). Modeling Prolactin Actions in Breast Cancer In Vivo: Insights from the NRL-PRL Mouse. In: Diakonova, PhD, M. (eds) Recent Advances in Prolactin Research. Advances in Experimental Medicine and Biology, vol 846. Springer, Cham. https://doi.org/10.1007/978-3-319-12114-7_9

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