Abstract
An introduction to the history of life cycle assessment (LCA) is provided as a segue into a more detailed presentation of the guidelines and principles of LCA. The term “life cycle” is defined and illustrated by means of a figure which is used to describe various system boundaries that a typical LCA can evaluate. Discussion then shifts to the four stages of the LCA process identified in the international standards for conducting a life cycle analysis. These principles are connected with the principles of green chemistry in order to highlight common goals related to both fields. The theoretical portion ends with a discussion of the virtues and limitations inherent in the currently accepted methodology. This section covers the notion of “burden shifting” as well as the complexity and arbitrary nature of several components of the LCA process. The use of software packages to simplify LCA is described in the context of an approach developed at GlaxoSmithKline known as Fast Life Cycle Assessment of Synthetic Chemistry (FLASCTM). The advantages of this software are explored by revisiting the synthesis of 7-aminocephalosporanic acid. The chapter concludes with a novel approach to teaching LCA in the context of green metrics to upper-level undergraduate students.
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References
Reduce (2012) http://www.coca-colacompany.com/stories/reduce. Accessed 7 May 2014
Guinee JB, Heijungs R, Huppes G, Zamagni A, Masoni P, Buonamici R, Ekvall T, Rydberg T (2011) Life cycle assessment: past, present and future. Environ Sci Tech 45:90–96. doi:10.1021/es101316v
Life cycle assessment: principles and practice (2006). http://nepis.epa.gov/Exe/ZyPDF.cgi/P1000L86.PDF?Dockey=P1000L86.PDF. Accessed 9 May 2014
Curran MA (1996) Environmental life-cycle assessment. McGraw-Hill, New York
Schaltegger S (1996) Life cycle assessment (LCA)—quo vadis?. Birkhauser Verlag, Basel
Guinee JB (2002) Handbook on life cycle assessment: operational guide to the ISO standards. Kluwer Academic Publishers, New York
Azapagic A (1999) Life cycle assessment and its application to process selection, design and optimisation. Chem Eng J 73:1–21. doi:10.1016/S1385-8947(99)00042-X
Anastas PT, Lankey RL (2000) Life cycle assessment and green chemistry: the yin and yang of industrial ecology. Green Chem 2:289–295. doi:10.1039/b005650m
Curran MA (2013) Life cycle assessment: a review of the methodology and its application to sustainability. Curr Opin Chem Eng 2:273–277. doi:10.1016/j.coche.2013.02.002
Gonzalez-Jimenez C, Curzons AD, Constable DJC, Cunningham VL (2004) Cradle-to-gate life cycle inventory and assessment of pharmaceutical compounds. Int J LCA 9:114–121. doi:10.1065/lca2003.11.141
Vervaeke M (2012) Life cycle assessment software for product and process sustainability analysis. J Chem Educ 89:884–890. doi:10.1021/ed200741b
Mercer SM, Andraos J, Jessop PG (2012) Choosing the greenest synthesis: a multivariate metric green chemistry exercise. J Chem Educ 89:215–220. doi:10.1021/ed200249v
Lancaster M (2010) Green chemistry: an introductory text, 2nd edn. RSC Paperbacks, Cambridge, pp 66–72
Lankey RL, Anastas PT (2002) Life-cycle approaches for assessing green chemistry technologies. Ind Eng Chem Res 41:4498–4502. doi:10.1021/ie0108191
Clark JH, Tavener SJ (2007) Alternative solvents: shades of green. Org Process Res Dev 11:149–155. doi:10.1021/op060160g
Raymond MJ, Slater CS, Savelski MJ (2010) LCA approach to the analysis of solvent waste issues in the pharmaceutical industry. Green Chem 12:1826–1834. doi:10.1039/c003666h
Burgess AA, Brennan DJ (2001) Application of life cycle assessment to chemical processes. Chem Eng Sci 56:2589–2604. doi:10.1016/S0009-2509(00)00511-X
Kralisch D (2009) Application of LCA in process development. In: Lapkin A, Constable DJC (eds) Green chemistry metrics: measuring and monitoring sustainable processes. Wiley-Blackwell, Chichester
Herrchen M, Werner K (2000) Use of the life-cycle assessment (LCA) toolbox for an environmental evaluation of production processes. Pure Appl Chem 72:1247–1252. doi:10.1351/pac200072071247
Tukker A (2002) Life-cycle assessment and the precautionary principle. Environ Sci Technol 36:70A–75A. doi:10.1021/es022213p
Schebek L (2009) Life-cycle analysis of biobased products. In: Ulber R, Sell D, Hirth T (eds) Renewable raw materials. Wiley-VCH Verlag GmbH & Co, KGaA, Weinheim
Curzons AD, Jimenez-Gonzalez C, Duncan AL, Constable DJC, Cunningham VL (2007) Fast life cycle assessment of synthetic chemistry (FLASCTM) tool. Int J LCA 12:272–280. doi:10.1065/lca2007.03.315
Jimenez-Gonzalez C, Kim S, Overcash MR (2000) Methodology for developing gate-to-gate life cycle inventory information. Int J LCA 5:153–159. doi:10.1065/lca2000.02.017
Jimenez-Gonzalez C (2000) Life cycle assessment in pharmaceutical applications. Dissertation, North Carolina State University
Henderson RK, Jimenez-Gonzalez C, Preston C, Constable DJC, Woodley JM (2008) EHS & LCA assessment for 7-ACA synthesis, a case study for comparing biocatalytic & chemical synthesis. Ind Biotechnol 4:180–192. doi:10.1089/ind.2008.4.180
Domenech X, Ayllon JA, Peral J, Rieradevall J (2002) How green is a chemical reaction? Application of LCA to green chemistry. Environ Sci Technol 36:5517–5520. doi:10.1021/es020001m
Jimenez-Gonzalez C, Constable DJC, Ponder CS (2012) Evaluating the ‘‘Greenness’’ of chemical processes and products in the pharmaceutical industry—a green metrics primer. Chem Soc Rev 41:1485–1498. doi:10.1039/c1cs15215g
Dunn PJ (2013) Pharmaceutical green chemistry process changes—how long does it take to obtain regulatory approval? Green Chem 15:3099–3104. doi:10.1039/c3gc41376d
Huebschmann S, Kralisch D, Loewe H, Breuch D, Petersen JH, Dietrich T, Scholz R (2011) Decision support towards agile eco-design of microreaction processes by accompanying (simplified) life cycle assessment. Green Chem 13:1694–1707. doi:10.1039/c1gc15054e
Tufvesson LM, Tufvesson P, Woodley JM, Borjesson P (2013) Life cycle assessment in green chemistry: overview of key parameters and methodological concerns. Int J Life Cycle Assess 18:431–444. doi:10.1007/s11367-012-0500-1
Wang Q, Gursel IV, Shang M, Hessel V (2013) Life cycle assessment for the direct synthesis of adipic acid in microreactors and benchmarking to the commercial process. Chem Eng J 234:300–311. doi:10.1016/j.cej.2013.08.059
Shonnard D, Lindner A, Nguyen N, Ramachandran PA, Fichana D, Hesketh R, Slater CS, Engler R (2012) Green engineering: integration of green chemistry, pollution prevention, and risk-based considerations. In: Kent JA (ed) Handbook of industrial chemistry and biotechnology, vol 1 and 2, 12th edn. Springer, New York
Constable DJC, Jimenez-Gonzalez CC (2012) Evaluating the greenness of synthesis. In: Li CJ (ed) Handbook of green chemistry volume 7: green synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Eissen M (2012) Sustainable production of chemicals—an educational perspective. Chem Educ Res Pract 13:103–111. doi:10.1039/c2rp90002e
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Dicks, A.P., Hent, A. (2015). An Introduction to Life Cycle Assessment. In: Green Chemistry Metrics. SpringerBriefs in Molecular Science(). Springer, Cham. https://doi.org/10.1007/978-3-319-10500-0_5
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