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Bioreactors for Mammalian Cells

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Animal Cell Culture

Part of the book series: Cell Engineering ((CEEN,volume 9))

Abstract

Cultivation of mammalian cells has become a routine technique. Nevertheless, design and layout of cell culture processes has to meet cell specific demands. Numerous bioreactors and cultivation systems for cell culture, either for production of biopharmaceuticals or for tissue engineering, have been developed. Due to the special characteristics of these cells specific solutions are required. Selection of a suitable type of cell culture bioreactor system and/or an appropriate operation mode (batch, fed-batch, and perfusion) is affected by technical, biological, economical and regulatory considerations. Obviously there is no single cultivation system suitable for all applications. Furthermore, to compare different bioreactor systems or operation modes experimentally for a certain application is time consuming and expensive. Therefore, selection of an appropriate bioreactor or cultivation system requires extensive knowledge and expertise. The following contribution gives an introduction to bioreactor systems and cultivation strategies applied.

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Acknowledgement

Chapters 1, 2, 3 and 4 were summarized from “Eibl R., Eibl D., Pörtner R., Catapano G., Czermak P. (2009): Cell and Tissue Reaction Engineering, Springer” with kind permission from Springer Science + Business Media

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  1. Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Denickestr. 15, D-21073, Hamburg, Germany

    R. Pörtner

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    Mohamed Al-Rubeai

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Pörtner, R. (2015). Bioreactors for Mammalian Cells. In: Al-Rubeai, M. (eds) Animal Cell Culture. Cell Engineering, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-319-10320-4_4

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