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Fungal Biofilms in Human Disease

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Biofilm-based Healthcare-associated Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 831))

Abstract

Fungal biofilms are an important clinical problem. A number of factors including the increasing use of indwelling medical devices wider prescription of broad spectrum antibiotics and an aging and more immuno-compromised patient population has combined to create an opportunity for yeasts and moulds to cause infection. It is also becoming increasingly clear that for a number of serious infections the development of a fungal biofilm is important in the pathophysiology of the infection.

This chapter will discuss the importance of fungal biofilms in different anatomical areas, will try to provide insights into how fungal biofilm infection should be diagnosed and treated and provide an explanation as to why biofilms may be difficult to treat effectively with routine antifungal regimens.

Finally it will discuss how our current level of knowledge of the development and biology of fungal biofilms may, in future, lead to a wider choice of therapeutic interventions.

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Authors and Affiliations

  1. Institute of Healthcare Associated Infection, University of the West of Scotland, Paisley, UK

    Craig Williams

  2. Infection and Immunity Research Group, Glasgow Dental School and Hospital, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

    Gordon Ramage

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  1. Fondazione Santa Lucia IRCCS, Microbial Biofilm Laboratory, Rome, Italy

    Gianfranco Donelli

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Williams, C., Ramage, G. (2015). Fungal Biofilms in Human Disease. In: Donelli, G. (eds) Biofilm-based Healthcare-associated Infections. Advances in Experimental Medicine and Biology, vol 831. Springer, Cham. https://doi.org/10.1007/978-3-319-09782-4_2

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