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Retinal AO OCT

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Optical Coherence Tomography

Abstract

The last two decades have witnessed extraordinary advances in optical technology to image noninvasively and at high resolution the posterior segment of the eye. Two of the most impactful technological advancements over this period have arguably been optical coherence tomography (OCT) and adaptive optics (AO). The strengths of these technologies complement each other and when combined have been shown to provide unprecedented, micron-scale resolution (<3 μm) in all three dimensions and sensitivity to image the cellular retina in the living eye. This powerful extension of OCT, that is AO-OCT, is the focus of this chapter. It presents key aspects of designing and implementing AO-OCT systems. Particular attention is devoted to the relevant optical properties of the eye that ultimately define these systems, AO componentry and operation tailored for ophthalmic use, and of course use of the latest technologies and methods in OCT for ocular imaging. It surveys the wide range of AO-OCT designs that have been developed for retinal imaging, with AO integrated into every major OCT design configuration. Finally, it reviews the scientific and clinical studies reported to date that show the exciting potential of AO-OCT to image the microscopic retina and fundus in ways not previously possible with other noninvasive methods and a look to future developments in this rapidly growing field.

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Authors and Affiliations

  1. Vision Science and Advanced Retinal Imaging Laboratory (VSRI) Department of Ophthalmology and Vision Science, University of California Davis, 4860 Y Street, Ste. 2400 , Sacramento, CA, 95817, USA

    Robert J. Zawadzki

  2. UC Davis RISE Eye–Pod Laboratory, Department of Cell Biology and Human Anatomy, University of California Davis, 4320 Tupper Hall, Davis, CA, 95616, USA

    Robert J. Zawadzki

  3. School of Optometry, Indiana University, 800 East Atwater Avenue, Bloomington, IN, 47405, USA

    Donald T. Miller

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  1. Center for Medical Physics and Biomedical Engineering, Medical University Vienna, General Hospital Vienna, Vienna, Austria

    Wolfgang Drexler

  2. Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    James G. Fujimoto

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Zawadzki, R.J., Miller, D.T. (2015). Retinal AO OCT. In: Drexler, W., Fujimoto, J. (eds) Optical Coherence Tomography. Springer, Cham. https://doi.org/10.1007/978-3-319-06419-2_63

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