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Physiological Functions and Regulation of TRPC Channels

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Mammalian Transient Receptor Potential (TRP) Cation Channels

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 223))

Abstract

The TRP-canonical (TRPC) subfamily, which consists of seven members (TRPC1–TRPC7), are Ca2+-permeable cation channels that are activated in response to receptor-mediated PIP2 hydrolysis via store-dependent and store-independent mechanisms. These channels are involved in a variety of physiological functions in different cell types and tissues. Of these, TRPC6 has been linked to a channelopathy resulting in human disease. Two key players of the store-dependent regulatory pathway, STIM1 and Orai1, interact with some TRPC channels to gate and regulate channel activity. The Ca2+ influx mediated by TRPC channels generates distinct intracellular Ca2+ signals that regulate downstream signaling events and consequent cell functions. This requires localization of TRPC channels in specific plasma membrane microdomains and precise regulation of channel function which is coordinated by various scaffolding, trafficking, and regulatory proteins.

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Authors and Affiliations

  1. Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 20892, USA

    Hwei Ling Ong, Lorena B. de Souza & Kwong Tai Cheng

  2. Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 10, Room 1N-113, Bethesda, MD, 20892, USA

    Indu S. Ambudkar

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  1. Hwei Ling Ong
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  2. Lorena B. de Souza
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  3. Kwong Tai Cheng
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  4. Indu S. Ambudkar
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Correspondence to Indu S. Ambudkar .

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  1. Laboratory Ion Channel Research, Campus Gasthuisberg, KU Leuven Department, Cell Mol Medicin, Leuven, Belgium

    Bernd Nilius

  2. Pharmakologie und Toxikologie, Universität des Saarlandes, Institut für Experimentelle u. Klinische, Homburg, Germany

    Veit Flockerzi

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Ong, H.L., de Souza, L.B., Cheng, K.T., Ambudkar, I.S. (2014). Physiological Functions and Regulation of TRPC Channels. In: Nilius, B., Flockerzi, V. (eds) Mammalian Transient Receptor Potential (TRP) Cation Channels. Handbook of Experimental Pharmacology, vol 223. Springer, Cham. https://doi.org/10.1007/978-3-319-05161-1_12

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