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Mouse Model of Subarachnoid Hemorrhage: Technical Note on the Filament Perforation Model

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Neurovascular Events After Subarachnoid Hemorrhage

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 120))

Abstract

Experiments using genetically engineered mice are regarded as indispensable to gaining a better understanding of the molecular pathophysiology in neuronal injury after subarachnoid hemorrhage (SAH). Therefore, mouse SAH models are becoming increasingly important. The circle of Willis perforation (cWp) model is the most frequently used mouse SAH model. We report and discuss the technical surgical approach, results, and difficulties associated with the cWp model, with reference to the existing literature. Our results largely confirmed previously published results. This model may be the first choice at present, because important pathologies can be reproduced in this model and most findings in the literature are based on it.

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Acknowledgments

CM has been supported by a personal research grant from the Swiss Foundation for Grants in Biology and Medicine and F. Hoffmann-La Roche Ltd., Basel, Switzerland.

Conflict of Interest Statement 

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan

    Carl Muroi MD, Masayuki Fujioka, Katsunori Iwasaki & Kenichi Mishima

  2. Department of Neurosurgery, Kantonsspital Aarau, Tellstrasse, CH-5001, Aarau, Switzerland

    Carl Muroi MD

  3. Neurocritical Care Unit, Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland

    Carl Muroi MD & Emanuela Keller MD

  4. Department of Intensive Care Medicine, University and University Hospital Bern, Bern, Switzerland

    Carl Muroi MD

  5. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Serge Marbacher MD, MSc & Javier Fandino MD

Authors
  1. Carl Muroi MD
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  2. Masayuki Fujioka
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  3. Serge Marbacher MD, MSc
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  4. Javier Fandino MD
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  5. Emanuela Keller MD
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  6. Katsunori Iwasaki
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  7. Kenichi Mishima
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Corresponding author

Correspondence to Carl Muroi MD .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Javier Fandino

  2. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Serge Marbacher

  3. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Ali-Reza Fathi

  4. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Carl Muroi

  5. Department of Neurosurgery Neurointensive Care Unit, University Hospital Zurich, Zurich, Switzerland

    Emanuela Keller

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© 2015 Springer International Publishing Switzerland

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Muroi, C. et al. (2015). Mouse Model of Subarachnoid Hemorrhage: Technical Note on the Filament Perforation Model. In: Fandino, J., Marbacher, S., Fathi, AR., Muroi, C., Keller, E. (eds) Neurovascular Events After Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement, vol 120. Springer, Cham. https://doi.org/10.1007/978-3-319-04981-6_54

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  • DOI: https://doi.org/10.1007/978-3-319-04981-6_54

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-04980-9

  • Online ISBN: 978-3-319-04981-6

  • eBook Packages: MedicineMedicine (R0)

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