Abstract
The development of glucose micro sensors for clinical use is driven by the aim of automatic blood glucose normalization in diabetic patients. An improved affinity viscometric sensor for continuous glucose monitoring (CGM) is presented by using a micro-electro-mechanical system (MEMS) with a differential capacitor. A numerical model using Reynolds equation is used to simulate the dynamic response under different viscosities, and the relationship between capacitance and viscosity is revealed. Compared to the previous version presented by Columbia University, the sensor designed in this paper has enhanced the capacitor by introducing a differential capacitance, which also avoided volume changes of the air and polymer solution chamber during the vibration, increasing the linear range of the sensor. In addition, the simulation results show that the sensor can be driven by a Gaussian Pulse resulting in a significant power saving, when compared to a sinusoidal excitation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Clark HR, Barbari TA (1999) Modeling the response time of an in vivo glucose affinity sensor. Biotechnol Prog 15:259–266
MiniMed Paradigm (2006) REAL-time insulin pump and continuous glucose monitoring system[P]. Medtronic MiniMed, San Antonio
Tracey Neithercott (2011) Continuous glucose monitoring system[J]. Diabetes Forecast 64:44–46
Schultz JS, Mansouri S et al (1982) Affinity sensor – a new technique for developing implantable sensors for glucose and other metabolites[J]. Diabetes Care 5(3):245–253
Schultz J, Sims G (1979) Affinity sensors for individual metabolites[J]. Biotechnol Bioeng Symp 9:65–71
Zhao yongjun, Li siqi et al (2007) A MEMS viscometric sensor device for continuous glucose monitoring[J]. J Micromech Microeng 17(12):2528–2537
Huang xian, Li siqi et al (2009) A capacitive MEMS viscometric sensor for affinity detection of glucose[J]. J Microelectromech Syst 18(6):1246–1254
Yang zhijun, Robert Kelley et al (2011) A numerical investigation of a capacitive viscometer with fluid–structure interaction using equivalent modeling[C]. Adv Mater Res Adv Mater Process, PTS 1–3(311–313):2423–2429
Lotters JC, Olthuis W et al (1999) A sensitive differential capacitance to voltage converter for sensor applications[J]. IEEE Trans Instrum Meas 48(1):89–96
Block H, North AM Dielectric relaxation in polymer solutions, advances in molecular relaxation processes. Elsevier Publishing Company, Amsterdam – Printed in the Netherlands 309
Sherman FS (1990) Viscous flow[M]. McGraw-Hill Higher Education, New York, pp 746–747
Batchelor GK (1998) An introduction to fluid dynamics[M]. Cambridge University Press, New York, pp 302–303
Acknowledgements
This work is supported by Natural Science Foundation of China (U1134004, 50905033), Guangdong Innovative Research Team Program (201001G0104781202), The National Basic Research Program of China (2011CB013100-G, National key technology support program (2012BAF12B10), Specialized Research Fund for the Doctoral Program of Higher Education of China (20094420120001)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer International Publishing Switzerland
About this paper
Cite this paper
Yang, Z., Wang, M., Bai, Y., Chen, X. (2014). A Differential Capacitive Viscometric Sensor for Continuous Glucose Monitoring. In: Wang, W. (eds) Mechatronics and Automatic Control Systems. Lecture Notes in Electrical Engineering, vol 237. Springer, Cham. https://doi.org/10.1007/978-3-319-01273-5_111
Download citation
DOI: https://doi.org/10.1007/978-3-319-01273-5_111
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-01272-8
Online ISBN: 978-3-319-01273-5
eBook Packages: EngineeringEngineering (R0)