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2.7 Neurobiological correlates of social exclusion and social pain

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Embitterment

Abstract

Human life is characterized by daily physical and social experiences, emotions, decisions and consequent behaviour. Tere are distributed neural networks, cell- and gene-function that process these in neuroplastic ways. One of the most powerful experiences in life is pain, a complex basic process for survival within an animal and human being, which can be of a physical or social nature. Physical pain is actual or potential tissue damage that causes mostly an unpleasant sensory and emotional experience. Social pain is the distress felt due to the actual or potential separation from social peers or negative social comparison.

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References

  • Braus DF (2010) Ein Blick ins Gehirn, 2nd edn. Stuttgart, Tieme

    Google Scholar 

  • Braus DF (2003) A picture of the mind. Nuclear magnetic resonance tomography gives the first view of the somatic basis of psychic processes. Med Monatsschr Pharm 26(2):45–51

    PubMed  Google Scholar 

  • Braus DF, Krauss JK, Strobel J (1994) The shoulder-hand syndrome afer stroke: a prospective clinical trial. Ann Neurol. 36(5):728–33

    Article  PubMed  Google Scholar 

  • Belforte JE, Zsiros V, Sklar ER, Jiang Z, Yu G, Li Y, Quinlan EM, Nakazawa K (2010) Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat Neurosci 13(1): 76–83

    Article  PubMed  Google Scholar 

  • Buck RW, Parke RD (1972) Behavioral and physiological response to the presence of a friendly or neutral person in two types of stressful situations. J Pers Soc Psychol 24(2):143–153

    Article  PubMed  Google Scholar 

  • Brown JL, Sheffield D, Leary MR, Robinson ME (2003) Social support and experimental pain. Psychosom Med 65(2):276–283

    Article  PubMed  Google Scholar 

  • Camras LA, Ribordy S, Hill J, Martino S, Spaccarelli S, Stefani R (1988) Recognition and posing of emotional expression by abused children and their mothers. Dev Psychol 24(6):776–781

    Article  Google Scholar 

  • Christmann C, Koeppe C, Braus DF, Ruf M, Flor H (2007) A simultaneous EEG-fMRI study of painful electric stimulation. Neuroimage 34(4):1428–37

    Article  PubMed  Google Scholar 

  • Coghill RC, McHaffie JG, Yen YF (2003) Neural correlates of interindividual differences in the subjective experience of pain. Proc Natl Acad Sci USA 100(14):8528–8542

    Article  Google Scholar 

  • Domes G, Heinrichs M, Gläscher J, Büchel C, Braus DF, Herpertz SC (2007) Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biol Psychiatry 62(10):1187–1190

    Article  PubMed  Google Scholar 

  • Eisenberger NI, Inagaki TK, Rameson LT, Mashal NM, Irwin MR (2009) An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences. Neuroimage 47(3):881–890

    Article  PubMed  Google Scholar 

  • Eisenberger NI, Way BM, Taylor SE, Welch WT, Lieberman MD (2007) Understanding genetic risk for aggression: clues from the brain’s response to social exclusion. Biol Psychiatry 61(9):1100–1108

    Article  PubMed  Google Scholar 

  • Eisenberger NI, Jarcho JM, Lieberman MD, Naliboff BD (2006) An experimental study of shared sensitivity to physical pain and social rejection. Pain 126(1–3):132–8

    Article  PubMed  Google Scholar 

  • Eisenberger NI, Lieberman MD (2004) Why rejection hurts: a common neural alarm system for physical and social pain. Trends Cogn Sci 8(7):294–300

    Article  PubMed  Google Scholar 

  • Eisenberger NI, Lieberman MD, Williams KD (2003) Does rejection hurt? An FMRI study of social exclusion. Sci 302(5643):290–2

    Article  Google Scholar 

  • Fiorillo CD, Tobler PN, Schultz W (2003) Discrete coding of reward probability and uncertainty by dopamine neurons. Sci 299(5614):1898–902

    Article  Google Scholar 

  • Foltz EL, White LE (1968) The role of rostral cingulotomy in ‘pain’ relief. Int J Neurol 6:353–373

    PubMed  Google Scholar 

  • Friston KJ (2009) Modalities, modes, and models in functional neuroimaging. Sci 326(5951):399–403

    Article  Google Scholar 

  • Heinz A, Braus DF, Smolka MN, Wrase J, Puls I, Hermann D, Klein S, Grusser SM, Flor H, Schumann G, Mann K, Buchel C (2005) Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci 8:20–21

    Article  PubMed  Google Scholar 

  • Hermann C, Hohmeister J, Demirakca S, Zohsel K, Flor H et al (2006). Long-term alteration of pain sensitivity in school-aged children with early pain experiences. Pain 125(3):278–85

    Article  PubMed  Google Scholar 

  • Hofbauer RK, Olausson HW, Bushnell MC (2006) Termal and tactile sensory deficits and allodynia in a nerve-injured patient: a multimodal psychophyscial and functional magnetic resonance imaging study. Clin J Pain 22(1):104–108

    Article  PubMed  Google Scholar 

  • Kandel ER, Squire LR (2000) Neuroscience: breaking down scientific barriers to the study of brain and mind. Sci 290(5494):1113–1120

    Article  Google Scholar 

  • Kennell J, Klaus M, McGrath S, Robertson S, Hinkley C (1991) Continuous emotional support during labor in US hospital: a randomized control trial. J Am Med Assoc 265(17):2197–2201

    Article  Google Scholar 

  • King KB, Reis HT, Porter LA, Norsen LH (1993) Social support and long-term recovery from coronary artery surgery: effects on patients and spouses. Health Psychol 12(1):56–63

    Article  PubMed  Google Scholar 

  • Kulik JA, Mahler HI (1989) Social support and recovery from surgery. Health Psychol 8(2):221–238

    Article  PubMed  Google Scholar 

  • Kuramochi M, Nakamura S (2009) Effects of postnatal isolation rearing and antidepressant treatment on the density of serotonergic and noradrenergic axons and depressive behavior in rats. Neurosci 163(1):448–55

    Article  Google Scholar 

  • Kwan CL, Diamant NE, Pope G, Mikula K, Mikulis DJ, Davis KD (2005) Abnormal forebrain activity in functional bowel disorder patients with chronic pain. Neurol 65(8):1268–1277

    Article  Google Scholar 

  • Lieberman MD, Eisenberger NI (2009) Neuroscience. Pains and pleasures of social life. Sci 323(5916):890–891

    Article  Google Scholar 

  • Masten CL, Eisenberger NI, Borofsky LA, Pfeifer JH, McNealy K, Mazziotta JC, Dapretto M (2009) Neural correlates of social exclusion during adolescence: understanding the distress of peer rejection. Soc Cogn Affect Neurosci 4(2):143–57

    Article  PubMed  Google Scholar 

  • Nakamura S (1991) Axonal sprouting of noradrenergic locus coeruleus neurons following repeated stress and antidepressant treatment. Prog Brain Res 88:587–598

    Article  PubMed  Google Scholar 

  • Panksepp J (2003) Neuroscience. Feeling the pain of social loss. Sci 302(5643):237–239

    Article  Google Scholar 

  • Rodriguez-Raecke R, Niemeier A, Ihle K, Ruether W, May A (2009) Brain gray matter decrease in chronic pain is the consequence and not the cause of pain. J Neurosci 29(44):13746–13750

    Article  PubMed  Google Scholar 

  • Schubert MI, Porkess MV, Dashdorj N, Fone KC, Auer DP (2009). Effects of social isolation rearing on the limbic brain: a combined behavioral and magnetic resonance imaging volumetry study in rats. Neurosci 159(1):21–30

    Article  Google Scholar 

  • Shih JC, Chen K, Ridd MJ (1999) Monoamine oxidase: From genes to behaviour. Annu Rev Neurosci 22:197–217

    Article  PubMed  Google Scholar 

  • Stanley B, Siever LJ (2010) The interpersonal dimension of borderline personality disorder: toward a neuropeptide model. Am J Psychiatry 167(1):24–39

    Article  PubMed  Google Scholar 

  • Taylor SE, Eisenberger NI, Saxbe D, Lehman BJ, Lieberman MD (2006) Neural responses to emotional stimuli are associated with childhood family stress. Biol Psychiatry 60(3):296–301

    Article  PubMed  Google Scholar 

  • Vlaev I, Seymour B, Dolan RJ, Chater N (2009) The price of pain and the value of suffering. Psychol Sci 20(3):309–17

    Article  PubMed  Google Scholar 

  • Wallace DL, Han MH, Graham DL, Green TA,V ialou V, Iniguez SD, Cao JL, Kirk A, Chakravarty S, Kumar A, Krishnan V, Neve RL, Cooper DC, Bolanos CA, Barrot M, McClung CA, Nestler EJ (2009) CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat Neurosci 12(2):200–209

    Article  PubMed  Google Scholar 

  • Weinstein N, Przybylski AK, Ryan RM (2009) Can nature make us more caring? Effects of immersion in nature on intrinsic aspirations and generosity. Pers Soc Psychol Bull 35(10):1315–1329

    Article  PubMed  Google Scholar 

  • Williams LE, Bargh JA (2008) Experiencing physical warmth promotes interpersonal warmth. Sci 322(5901):606–607

    Article  Google Scholar 

  • Witting N, Kupers RC, Svensson P, Jensen TS (2006) A PET activation study of brush-evoked allodynia in patients with nerve injury pain. Pain 120(1–2):145–154

    Article  PubMed  Google Scholar 

  • Wollgarten-Hadamek I, Hohmeister J, Demirakca S, Zohsel K, Flor H, Hermann C (2009) Do burn injuries during infancy affect pain and sensory sensitivity in later childhood? Pain 141(1–2):165–72

    Article  PubMed  Google Scholar 

  • Xie YF, Huo FQ, Tang JS (2009) Cerebral cortex modulation of pain. Acta Pharmacol Sin 30(1):31–41

    Article  PubMed  Google Scholar 

  • Zaza C, Baine N (2002) Cancer pain and psychosocial factors: a critical review of the literature. J Pain Symptom Manag 24(5):526–542

    Article  Google Scholar 

  • Zhong CB, Leonardelli GJ (2008) Cold and lonely: does social exclusion literally feel cold? Psychol Sci 19(9):838–42

    Article  PubMed  Google Scholar 

  • Zhou X, Vohs KD, Baumeister RF (2009) The symbolic power of money: reminders of money alter social distress and physical pain. Psychol Sci 20(6):700–6

    Article  PubMed  Google Scholar 

  • Zhuo M (2008) Cortical excitation and chronic pain. Trends Neurosci 31(4):199–207

    Article  PubMed  Google Scholar 

  • Zhou L, Huang KX, Kecojevic A, Welsh AM, Koliatsos VE (2006) Evidence that serotonin re-uptake modulators increase the density of serotonin innervation in the forebrain. J Neurochem 96(2):396–406

    Article  PubMed  Google Scholar 

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Berkefeld, A.K., Braus, D.F. (2011). 2.7 Neurobiological correlates of social exclusion and social pain. In: Linden, M., Maercker, A. (eds) Embitterment. Springer, Vienna. https://doi.org/10.1007/978-3-211-99741-3_8

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