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Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach

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Neuropsychiatric Disorders An Integrative Approach

Part of the book series: Journal of Neural Transmission. Supplementa ((NEURALTRANS,volume 72))

Abstract

A growing body of evidence implicates impairments in brain insulin signaling in early sporadic Alzheimer disease (sAD) pathology. However, the most widely accepted hypothesis for AD aetiology stipulates that pathological aggregations of the amyloid β (Aβ) peptide are the cause of all forms of Alzheimer’s disease. Streptozotocin-intracerebroventricularly (STZ-icv) treated rats are proposed as a probable experimental model of sAD. The current work reviews evidence obtained from this model indicating that central STZ administration induces brain pathology and behavioural alterations resembling those in sAD patients. Recently, alterations of the brain insulin system resembling those in sAD have been found in the STZicv rat model and are associated with tau protein hyperphosphorylation and Aβ-like aggregations in meningeal vessels. In line with these findings the hypothesis has been proposed that insulin resistance in the brain might be the primary event which precedes the Aβ pathology in sAD.

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Authors and Affiliations

  1. Departments of Clinical Neurophysiology and Neurology, Vrije Universiteit Medical Centre, De Boelelaan 1181, PO Box 7057, 1007, MB, Amsterdam, Netherlands

    M. Salkovic-Petrisic MD, PhD

  2. Department of Pharmacology, Medical School, University of Zagreb, Salata 11, HR-10000, Zagreb, Croatia

    M. Salkovic-Petrisic MD, PhD

  3. Department of Pathology, University of Heidelberg, Heidelberg, Germany

    S. Hoyer

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  1. M. Salkovic-Petrisic MD, PhD
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Editors and Affiliations

  1. Klinik und Poliklinik für Kinder- und Jugendpsychiatrie und Psychotherapie, Würzburg, Germany

    M. Gerlach

  2. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Würzburg, Germany

    Jürgen Deckert

  3. Prince of Wales Medical Research Institute, Sydney, Australia

    K. Double

  4. Institut für Virologie und Immunobiologie, Würzburg, Germany

    E. Koutsilieri

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Salkovic-Petrisic, M., Hoyer, S. (2007). Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach. In: Gerlach, M., Deckert, J., Double, K., Koutsilieri, E. (eds) Neuropsychiatric Disorders An Integrative Approach. Journal of Neural Transmission. Supplementa, vol 72. Springer, Vienna. https://doi.org/10.1007/978-3-211-73574-9_28

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  • DOI: https://doi.org/10.1007/978-3-211-73574-9_28

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