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FDG-PET study of the bilateral subthalamic nucleus stimulation effects on the regional cerebral metabolism in advanced Parkinson disease

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Advances in Functional and Reparative Neurosurgery

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 99))

Summary

The aim of the study was to evaluate the changes in regional cerebral metabolic rate of glucose (rCMRGlu) induced by bilateral subthalamic nucleurs (STN) stimulation in advanced Parkinson’s disease (PD). 18F-Fluorodeoxyglucose (FDG) PET data obtained before and one month after stimulation were analyzed with statistical parametric mapping (SPM). As a result of clinically effective bilateral STN stimulation, rCMRGlu increased in lateral globus pallidus (GP), upper brain stem, dorsolateral prefrontal cortex (DLPFC) and posterior parietal-occipital cortex, and decreased in the orbital frontal cortex and parahippocampus gyrus (p<0.001). We conclude that the alleviation of clinical symptoms in advanced PD by bilateral STN stimulation may be the result of activation of both ascending and descending pathways from STN and of restoration of the impaired higher-order cortex functions.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Shanghai Second Medical University Ruijin Hospital, 197 Ruijin Raod, Shanghai, 200025, P.R. China

    D. Li, S. Zan & B. Sun

  2. PET Center, Shanghai Huashan Hospital, Shanghai, P.R. China

    C. Zuo, Y. Guan & J. Shen

  3. Department of Neurology, Shanghai First Hospital, Shanghai, P.R. China

    Y. Zhao

Authors
  1. D. Li
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  2. C. Zuo
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  3. Y. Guan
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  4. Y. Zhao
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  5. J. Shen
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  6. S. Zan
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  7. B. Sun
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Corresponding author

Correspondence to B. Sun .

Editor information

Editors and Affiliations

  1. Yonsei University College of Medicine, Seoul, Korea

    Jin Woo Chang

  2. Nihon University, Tokyo, Japan

    Yoichi Katayama  & Takamitsu Yamamoto  & 

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© 2006 Springer-Verlag

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Li, D. et al. (2006). FDG-PET study of the bilateral subthalamic nucleus stimulation effects on the regional cerebral metabolism in advanced Parkinson disease. In: Chang, J.W., Katayama, Y., Yamamoto, T. (eds) Advances in Functional and Reparative Neurosurgery. Acta Neurochirurgica Supplementum, vol 99. Springer, Vienna. https://doi.org/10.1007/978-3-211-35205-2_10

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  • DOI: https://doi.org/10.1007/978-3-211-35205-2_10

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-35204-5

  • Online ISBN: 978-3-211-35205-2

  • eBook Packages: MedicineMedicine (R0)

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