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Medicinal agents incorporating the 1,2-diamine functionality

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 33))

Abstract

The 1,2-diamine (vicinal diamine) functionality is a remarkable template which displays a broad spectrum of biological activity. For the purpose of this review, molecules possessing two nitrogen atoms separated by two carbon atoms, at least one of which being sp3-hydridized, will be considered to be 1,2-diamines. Structural units such as piperazine and imidazolidine will be included as examples of 1,2-diamines. The 1,2-diamine conformation may be found in many important compounds including antiarrhythmics, antihypertensives, antipsychotics, analgesics, antianxiety agents, local anesthetics, anticonvulsants, gastrointestinal agents, anticancer drugs, and antiparasitic agents. The number of compounds falling into the 1,2-diamine category as defined above is considerable. Consequently, this review is intended to be illustrative rather than exhaustive.

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Authors and Affiliations

  1. Department of Chemistry, University of Notre Dame, 46556, Notre Dame, IN, USA

    Erik T. Michalson & Jacob Szmuszkovicz

Authors
  1. Erik T. Michalson
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  2. Jacob Szmuszkovicz
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Editors and Affiliations

  1. Basel, Switzerland

    Ernst Jucker

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© 1989 Birkhäuser Verlag Basel

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Michalson, E.T., Szmuszkovicz, J. (1989). Medicinal agents incorporating the 1,2-diamine functionality. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 33. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9146-2_6

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  • DOI: https://doi.org/10.1007/978-3-0348-9146-2_6

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9925-3

  • Online ISBN: 978-3-0348-9146-2

  • eBook Packages: Springer Book Archive

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