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Glucosamine and chondroitin sulfates in the treatment of osteoarthritis: a survey

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 55))

Summary

For more than 30 years, non-steroidal anti-inflammatory drugs (NSAIDs) have been used as standards in the treatment of osteoarthritis (OA). Serious and often life-threatening adverse effects due to these agents are common. Clinical findings have revealed that glucosamine sulfate and chondroitin sulfate are effective and safer alternatives to alleviate symptoms of OA. Experimental evidence indicates that these compounds and their low molecular weight derivatives have a particular tropism for cartilage where they serve as substrates in the biosynthesis of component building blocks. This paper is a literature review of the chemistry, mechanism of action, pharmacokinetics, clinical efficacy and safety of these two nutraceuticals.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90089, USA

    Gerlie C. de los Reyes, Robert T. Koda & Eric J. Lien

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  1. Gerlie C. de los Reyes
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  2. Robert T. Koda
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  3. Eric J. Lien
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  1. Steinweg 28, Ettingen, CH-4107, Switzerland

    Ernst Jucker

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de los Reyes, G.C., Koda, R.T., Lien, E.J. (2000). Glucosamine and chondroitin sulfates in the treatment of osteoarthritis: a survey. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 55. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8385-6_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8385-6_3

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9544-6

  • Online ISBN: 978-3-0348-8385-6

  • eBook Packages: Springer Book Archive

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