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Muscarinic control of airway mucus secretion

  • Chapter
Muscarinic Receptors in Airways Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Secretory elements in the airways have a parasympathetic (cholinergic) supply, and activation of cholinergic nerves or administration of cholinomimetic drugs induces marked increases in secretion. In health, secreted high molecular weight glycoproteins (mucins) comprise a small proportion (~ 1%) of the thin layer of aqueous liquid (often termed “mucus”) which overlies the surface epithelium of the airways. The liquid also contains electrolytes, immunoglobulins, plasma-derived proteins (for example albumin), lipids, enzymes, anti-enzymes, antibacterials, cell products and mediators. The relative contribution of each component to the normal functioning of the liquid is comparatively unknown, and the relevance of the liquid to airway homeostasis is, for the most part, only theoretical [1]. Mucins possess viscoelastic properties which confer upon the liquid the ability to be transported on the tips of beating cilia. Airborne particles are trapped in the liquid and are removed from the airways by mucociliary clearance. In disease, changes in the amount of liquid, or its viscoelasticity, or in the relative proportion of its components, convert a normally protective mechanism into a pathophysiological one. The altered mucus is difficult to clear and accumulates in the airways. The resulting airflow limitation contributes to morbidity and mortality in bronchial diseases such as asthma, chronic bronchitis and cystic fibrosis (CF).

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Authors and Affiliations

  1. Thoracic Medicine, National Heart & Lung Institute (Imperial College), Dovehouse Street, London, SW3 6LY, UK

    Duncan F. Rogers

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  1. Dept. of Molecular Pharmacology, University of Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands

    Johan Zaagsma  & Herman Meurs  & 

  2. Department of Research Management, Pharma Bio-Research Group B.V., P.O. Box 200, 9470 AE, Zuidlaren, The Netherlands

    Ad F. Roffel

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© 2001 Springer Basel AG

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Rogers, D.F. (2001). Muscarinic control of airway mucus secretion. In: Zaagsma, J., Meurs, H., Roffel, A.F. (eds) Muscarinic Receptors in Airways Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8358-0_8

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  • DOI: https://doi.org/10.1007/978-3-0348-8358-0_8

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9532-3

  • Online ISBN: 978-3-0348-8358-0

  • eBook Packages: Springer Book Archive

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