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Quasispecies and the development of new antiviral strategies

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 60))

Summary

RNA virus populations consist of complex and dynamic mutant distributions, rather than defined genomic sequences. This feature confers great adaptability on viruses and is partly responsible for current difficulties of viral disease prevention and control. Mutant distributions, also termed mutant swarms or mutant clouds, were first proposed in a theory of molecular evolution termed quasispecies theory. The theoretical formulation of quasispecies and its links to present day RNA viruses are discussed. The need to accommodate antiviral strategies to the dynamic nature of viral populations is emphasized. In particular, recent results on viral extinction associated with enhanced mutagenesis (virus entry into error catastrophe) are reviewed and presented as an example of how the understanding of viruses as quasispecies could lead to a potential practical application in medicine.

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Abbreviations

VSV:

vesicular stomatitis virus

HIV:

human immunodeficiency virus

FMDV:

foot-and-mouth-disease virus

HCV:

hepatitis C virus

PV:

polio virus

FU:

5-fluorouracil

AZT:

5-azacytidine

References

  1. M. Eigen:Naturwissenschaften 58 465 (1971).

    PubMed  CAS  Google Scholar 

  2. M. Eigen and P. Schuster: The hypercycle. A principle of natural self-organization,Springer, Berlin 1979.

    Google Scholar 

  3. M. Eigen and C.K. Biebricher, in: E. Domingo, P. Ahlquist and J.J. Holland (eds.): RNA genetics, Vol. 3, 211–245, CRC Press, Boca Raton, FL 1988, 211–245.

    Google Scholar 

  4. M. Eigen:Biophys. Chem. 85 101 (2000).

    PubMed  CAS  Google Scholar 

  5. M. Eigen: Steps towards life, Oxford University Press, Oxford 1992.

    Google Scholar 

  6. A. Delsemme: Our cosmic origins. From the big bang to the emergence of life and intel-ligence, Cambridge University Press, Cambridge 1998.

    Google Scholar 

  7. C.K. Biebricher, in: E. Domingo, R.G. Webster and J.J. Holland (eds.): Origin and evolu-tion of viruses, Academic Press, San Diego 1999, 65–85.

    Google Scholar 

  8. E. Domingo, D. Sabo, T. Taniguchi and C. Weissmann : Cell 13 735 (1978).

    PubMed  CAS  Google Scholar 

  9. D.A. Steinhauer, J.C. de la Torre and J.J. Holland:J. Virol. 63 2063 (1989).

    PubMed  CAS  Google Scholar 

  10. M. Eigen:Trends. Microbiol. 4, 216 (1996).

    PubMed  CAS  Google Scholar 

  11. C.O. Wilke, C. Ronnewinkel and T. Martinetz : Physics Reports 349 395 (2001).

    CAS  Google Scholar 

  12. C.O. Wilke, J.L. Wang, C. Ofria, R.E. Lenski and C. Adami:Nature 412 331 (2001).

    PubMed  CAS  Google Scholar 

  13. M.C. Boerlijst, S. Boenhoefer and M.A. Nowak:Proc. R. Soc. Lond. B 263 1577 (1966).Quasispecies and the development of new antiviral strategies

    Google Scholar 

  14. C.O. Wilke and C. Adami Trends Ecol. Evol. in press (2002).

    Google Scholar 

  15. E. Domingo, in: A. Granoff and R.G. Webster (eds.): Encyclopedia of Virology, Academic Press, London 1999, 1431–1436.

    Google Scholar 

  16. D.G. Sharp:Prog. Med. Virol. 10 64 (1968).

    PubMed  CAS  Google Scholar 

  17. D.C. Reanney:Cold Spring Harb. Symp. Quant. Biol. 52 751 (1987).

    PubMed  CAS  Google Scholar 

  18. J.F. Atkins, in: R.F. Gesteland and J.F. Atkins (eds.): The RNA World, Cold Spring Harbor Laboratory Press, New York 1993, 535–556.

    Google Scholar 

  19. J. Holland, K. Spindler, F. Horodyski, E. Grabau, S. Nichol and S. VandePol:Science 215 1577 (1982).

    PubMed  CAS  Google Scholar 

  20. N. Charpentier, M. Dávila, E. Domingo and C. Escarmís:Virology 223 10 (1996).

    PubMed  CAS  Google Scholar 

  21. I.M. Moreno, J.M. Malpica, E. Rodriguez-Cerezo and F. Garcia-Arenal:J. Virol. 71 9157(1997).

    PubMed  CAS  Google Scholar 

  22. J.C. de la Torre and J.J. Holland:J. Virol. 64 6278 (1990).

    PubMed  Google Scholar 

  23. K.M. Chumakov, L.B. Powers, K.E. Noonan, I.B. Roninson and I.S. Levenbook:Proc. Natl.Acad. Sci. USA 88 199 (1991).

    PubMed  CAS  Google Scholar 

  24. M.N. Teng, M.B. Oldstone and J.C. de la Torre : Virology 223 113 (1996).

    PubMed  CAS  Google Scholar 

  25. R. Miralles, P.J. Gerrish, A. Moya and S.F. Elena : Science 285 1745 (1999).

    PubMed  CAS  Google Scholar 

  26. P.J. Gerrish and R.E. Lenski:Genetica 103 127 (1998).

    Google Scholar 

  27. E. Domingo, C. Biebricher, M. Eigen and J.J. Holland: Quasispecies and RNA virus evo-lution: principles and consequences, Landes Bioscience, Austin 2001.

    Google Scholar 

  28. J.J. Holland (ed.): Genetic diversity of RNA viruses, Vol. 176. Current topics in microbi-ology and immunology, Springer-Verlag, Berlin 1992.

    Google Scholar 

  29. E. Batschelet, E. Domingo and C. Weissmann:Gene 1 27 (1976).

    PubMed  CAS  Google Scholar 

  30. J.W. Drake and J.J. Holland:Proc. Natl. Acad. Sci. USA 96 13910 (1999).

    PubMed  CAS  Google Scholar 

  31. E. Domingo and J.J. Holland, in: S.S. Morse (ed.): Evolutionary biology of viruses, Raven Press, New York 1994, 161–184.

    Google Scholar 

  32. E. Domingo, J.J. Holland, C. Biebricher and M. Eigen, in: A. Gibbs, C. Calisher and F.García-Arenal (eds.): Molecular evolution of the viruses, Cambridge University Press, Cambridge 1995, 171–180.

    Google Scholar 

  33. E. Domingo, A. Mas, E. Yuste, N. Pariente, S. Sierra, M. Gutiérrez-Riva and L. Menéndez-Arias, in: E. Jucker (ed.): Progress in drug research, vol. 57, Birkhäuser Verlag, Basel 2001, 77–115.

    Google Scholar 

  34. S.S. Morse (ed): Emerging viruses, Oxford University Press, Oxford 1993.

    Google Scholar 

  35. S.S. Morse (ed): The evolutionary biology of viruses, Raven Press, New York 1994.

    Google Scholar 

  36. A. Gibbs, C. Calisher and F. García-Arenal (eds.): Molecular basis of virus evolution, Cam-bridge University Press, Cambridge 1995.

    Google Scholar 

  37. K. Saha, J. Zhang, A. Gupta, R. Dave, M. Yimen and B. Zerhouni:Nat. Med. 7, 65 (2001).

    PubMed  CAS  Google Scholar 

  38. K.A. Crandall (ed.): The evolution of HIV, The Johns Hopkins University Press, Baltimore and London 1999.

    Google Scholar 

  39. E. Baranowski, C.M. Ruíz-Jarabo, N. Pariente, N. Verdaguer and E. Domingo: Adv. Virus Res. in press (2003).

    Google Scholar 

  40. S.J. Flint, L.W. Enquist, R.M. Krug, V.R. Racaniello and A.M. Skalka: Virology. Molecular biology, pathogenesis and control, ASM Press, Washington D.C. 2000.

    Google Scholar 

  41. E. Domingo, E. Martínez-Salas, F. Sobrino, J.C. de la Torre, A. Portela, J. Orlin, C. López-Galindez, P. Pérez-Breña, N. Villanueva, R. Nájera et al.:Gene 40 1 (1985).

    PubMed  CAS  Google Scholar 

  42. S. Wain-Hobson, in: S.S. Morse (ed.): Evolutionary biology of viruses, Raven Press, New York 1994, 185–209.

    Google Scholar 

  43. E. Domingo, R.G. Webster and J.J. Holland (eds.): Origin and evolution of viruses, Aca-demic Press, San Diego 1999.

    Google Scholar 

  44. E. Domingo, C. Escarmís, L. Menéndez-Arias and J.J. Holland, in: E. Domingo, R.G. Web-ster and J.J. Holland (eds.): Origin and evolution of viruses, Academic Press, San Diego 1999, 141–161.

    Google Scholar 

  45. L. Menéndez-Arias: Prog. Nucleic Acid Res. Mol. Biol. 71 91 (2002).

    PubMed  Google Scholar 

  46. A.M. Borman, S. Paulous and F. Clavel:J. Gen. Virol. 77, 419 (1996).

    PubMed  CAS  Google Scholar 

  47. M. Nijhuis, R. Schuurman, D. de Jong, J. Erickson, E. Gustchina, J. Albert, P. Schipper, S. Gulnik and C.A. Boucher : AIDS 13 2349 (1999).

    PubMed  CAS  Google Scholar 

  48. B. Borrego, I.S. Novella, E. Giralt, D. Andreu and E. Domingo:J. Virol. 67 6071 (1993).

    PubMed  CAS  Google Scholar 

  49. S. Walmsley, B. Bernstein, M. King, J. Arribas, G. Beall, P. Ruane, M. Johnson, D. John-son, R. Lalonde, A. Japour, S. Brun and E. Sun:N. Engl. J. Med. 346 2039 (2002).

    PubMed  CAS  Google Scholar 

  50. D. Botstein:Ann. NY Acad. Sci. 354, 484 (1980).

    PubMed  CAS  Google Scholar 

  51. D. Zimmern, in: E. Domingo, J.J. Holland and P. Ahlquist (eds.): RNA genetics, vol. 2,CRC Press Inc., Boca Raton, Florida 1988, 211–240.

    Google Scholar 

  52. A.E. Gorbalenya, in: A. Gibbs, C.H. Calisher and F. García-Arenal (eds.): Molecular basis of virus evolution, Cambridge University Press, Cambridge 1995, 49–66.

    Google Scholar 

  53. J.J. Holland and E. Domingo:Virus Genes 16 13 (1998).

    PubMed  CAS  Google Scholar 

  54. E. Baranowski, C.M. Ruiz-Jarabo and E. Domingo:Science 292 1102 (2001).

    PubMed  CAS  Google Scholar 

  55. M.E.J. Woolhouse, J.P. Webster, E. Domingo, B. Charlesworth and B.R. Levin: Nature Genetics 32 569 (2002).

    PubMed  CAS  Google Scholar 

  56. V. Lohmann, E Körner, A. Dobierzewska and R. Bartenschlager:J. Virol. 75, 1437 (2001).

    PubMed  CAS  Google Scholar 

  57. J.T. Guo, V.V. Bichko and C. Seeger:J. Virol. 75, 8516 (2001).

    PubMed  CAS  Google Scholar 

  58. E. Baranowski, C.M. Ruíz Jarabo, P. Lim and E. Domingo:Virology 288 192 (2001).

    PubMed  CAS  Google Scholar 

  59. E. Domingo, C.M. Ruíz Jarabo, A. Arias, C. Molina-Paris, C. Briones, E. Baranowski and C. Escarmís, in: A. Matsumori and R. Ruffy (eds.): Proceedings of the International Congress on Cardiomyopathies and heart failure, Kluwer Academic Publishers, London, 2003; in press.

    Google Scholar 

  60. C.M. Ruíz Jarabo, A. Arias, E. Baranowski, C. Escarmís and E. Domingo:J. Virol. 74 3543(2000).

    PubMed  Google Scholar 

  61. C.M. Ruíz-Jarabo, A. Arias, C. Molina-París, C. Briones, E. Baranowski, C. Escarmís and E. Domingo:J. Mol. Biol. 315, 285 (2002).

    PubMed  Google Scholar 

  62. A. Arias, E. Lázaro, C. Escarmís and E. Domingo:J. Gen. Virol. 82 1049 (2001).

    PubMed  CAS  Google Scholar 

  63. E. Domingo:Virology 270 251 (2000).

    PubMed  CAS  Google Scholar 

  64. E. Domingo, C.M. Ruíz Jarabo, S. Sierra, A. Arias, N. Pariente, E. Baranowski and C. Escar-mís:Virus Res. 82 39 (2002).

    PubMed  CAS  Google Scholar 

  65. C. Escarmís, M. Dávila, N. Charpentier, A. Bracho, A. Moya and E. Domingo:J. Mol. Biol. 264 255 (1996).

    PubMed  Google Scholar 

  66. M. Shena (ed.): DNA microarrays. A practical approach, Oxford University Press, Oxford 2000.

    Google Scholar 

  67. J.G. Hacia, W. Makalowski, K. Edgemon, M.R. Erdos, C.M. Robbins, S.P. Fodor, L.C. Brody and F.S. Collins:Nat. Genet. 18 155 (1998).

    PubMed  CAS  Google Scholar 

  68. N.P. Gerry, N.E. Witowski, J. Day, R.P. Hammer, G. Barany and F. Barany:J. Mol. Biol. 292 251 (1999).

    PubMed  CAS  Google Scholar 

  69. K.H. Buetow, M. Edmonson, R. MacDonald, R. Clifford, R. Yip, J. Kelley, D.P. Little, R. Strausberg, H. Koester, C.R. Cantor et al.:Proc. Natl. Acad. Sci. USA 98 581 (2001).

    PubMed  CAS  Google Scholar 

  70. M.J. Kozal, N. Shah, N. Shen, R. Yang, R. Fucini, T.C. Merigan, D.D. Richman, D. Mor-ris, E. Hubbell, M. Chee et al.:Nat. Med. 2 753 (1996).

    PubMed  CAS  Google Scholar 

  71. G. Amexis, P. Oeth, K. Abel, A. Ivshina, F. Pelloquin, C.R. Cantor, A. Braun and K. Chu-makov:Proc. Natl. Acad. Sci. USA 98 12097 (2001).

    PubMed  CAS  Google Scholar 

  72. P. Borrow, H. Lewicki, X. Wei, M.S. Horwitz, N. Peffer, H. Meyers, J.A. Nelson, J.E. Gairin, B.H. Hahn, M.B. Oldstone et al.:Nat. Med. 3, 205 (1997).

    PubMed  CAS  Google Scholar 

  73. C.A. Wyatt, L. Andrus, B. Brotman, F. Huang, D.H. Lee and A.M. Prince:J. Virol. 72 1725(1998).

    PubMed  CAS  Google Scholar 

  74. A.C. Karlsson, H. Gaines, M. Sallberg, S. Lindback and A. Sonnerborg:J. Virol. 73, 6191(1999).

    PubMed  CAS  Google Scholar 

  75. C. Briones, A. Mas, G. Gómez-Mariano, C. Altisent, L. Menéndez-Arias, V. Soriano and E. Domingo:Virus Res. 66 13 (2000).

    PubMed  CAS  Google Scholar 

  76. E. Domingo:J. Virol. 76 463 (2002).

    CAS  Google Scholar 

  77. E. Domingo, in: E. Jucker (ed.): Progress in drug research, vol. 33, Birkhäuser Verlag, Basel 1989, 93–133

    Google Scholar 

  78. E. Domingo and J.J. Holland:Annu. Rev. Microbiol. 51 151 (1997).

    PubMed  CAS  Google Scholar 

  79. J.J. Holland, J.C. de la Torre and D.A. Steinhauer:Curr. Top. Microbiol. Immunol. 176 1 (1992).

    PubMed  CAS  Google Scholar 

  80. E. Domingo and J.J. Holland: Genet. Eng. (NY) 14 13 (1992).

    CAS  Google Scholar 

  81. P. Schuster and P.F. Stadler, in: E. Domingo, R.G. Webster and J.J. Holland (eds.): Origin and evolution of viruses, Academic Press, San Diego 1999, 1–24.

    Google Scholar 

  82. M. Eigen:Proc. Natl. Acad. Sci. USA 99 13374 (2002).

    PubMed  CAS  Google Scholar 

  83. D. Alves and J.F. Fontanari:Physical Review E 57, 7008 (1998).

    CAS  Google Scholar 

  84. M. Nilsson and N. Snoad:Phys. Rev. Lett. 84 191 (2000).

    PubMed  CAS  Google Scholar 

  85. J.J. Holland, E. Domingo, J.C. de la Torre and D.A. Steinhauer:J. Virol. 64 3960 (1990).

    PubMed  CAS  Google Scholar 

  86. V.K. Pathak and H.M. Temin:J. Virol. 66 3093 (1992).

    PubMed  CAS  Google Scholar 

  87. L.A. Loeb, J.M. Essigmann, F. Kazazi, J. Zhang, K.D. Rose and J.I. Mullins:Proc. Natl. Acad.Sci. USA 96 1492 (1999).

    PubMed  CAS  Google Scholar 

  88. S. Sierra, M. Dávila, P.R. Lowenstein and E. Domingo:J. Virol. 74 8316 (2000).

    PubMed  CAS  Google Scholar 

  89. N. Pariente, S. Sierra, P.R. Lowenstein and E. Domingo:J. Virol. 75, 9723 (2001).

    PubMed  CAS  Google Scholar 

  90. C. Escarmís, G. Gómez-Mariano, M. Dávila, E. Lázaro and E. Domingo:J. Mol. Biol. 315 647 (2002).

    PubMed  Google Scholar 

  91. E. Lázaro, C. Escarmís, E. Domingo and S.C. Manrubia:J. Virol. 76 8675 (2002).

    PubMed  Google Scholar 

  92. S. Crotty, D. Maag, J.J. Arnold, W. Zhong, J.Y.N. Lau, Z. Hong, R. Andino and C.E. Cameron:Nat. Med. 6 1375 (2000).

    PubMed  CAS  Google Scholar 

  93. S. Crotty, C.E. Cameron and R. Andino:Proc. Natl. Acad. Sci. USA 98 6895 (2001).

    PubMed  CAS  Google Scholar 

  94. J.D. Grad and C.E. Cameron:Virology 298 175 (2002).

    Google Scholar 

  95. E. De Clercq:Adv. Virus Res. 42 1 (1993).

    PubMed  Google Scholar 

  96. J.S. Salt:Br. Vet. J. 149 207 (1993).

    PubMed  CAS  Google Scholar 

  97. J.C. de la Torre, B. Alarcón, E. Martínez-Salas, L. Carrasco and E. Domingo:J. Virol. 61 233 (1987).

    PubMed  Google Scholar 

  98. A. Airaksinen, N. Pariente, L. Menéndez-Arias and E. Domingo: Virology in press (2003).

    Google Scholar 

  99. E. Martínez-Salas, J. Ortín and E. Domingo:Gene 35, 55 (1985).

    PubMed  Google Scholar 

  100. A. Grande-Pérez, S. Sierra, M.G. Castro, E. Domingo and P.R. Lowenstein:Proc. Natl.Acad. Sci. USA 99 12938 (2002).

    PubMed  Google Scholar 

  101. C.M. Ruíz-Jarabo, C. Ly, E. Domingo and J.C. de la Torre: Virology in press (2003).

    Google Scholar 

  102. J.B. McCormick, I.J. King, P.A. Webb, C.L. Scribner, R.B. Craven, K.M. Johnson, L.H. Elliott and R. Belmont-Williams:N. Engl. J. Med. 314 20 (1986).

    PubMed  CAS  Google Scholar 

  103. E. Domingo, in: R.A. Dixon, M.J. Harrison and M.J. Roossinck (eds.): Proceedings 10thAnniversary Symposium. The Samuel Roberts Noble Foundation, Plant Biology Division, The Samuel Roberts Foundation, Ardmore 1999, 79–90.

    Google Scholar 

  104. M.A. Nowak: Trends Ecol. Evol. 4 118 (1992).

    Google Scholar 

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Authors and Affiliations

  1. Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Universidad Autónoma de Madrid, Cantoblanco, Madrid, 28049, Spain

    Esteban Domingo

  2. Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, 28130, Spain

    Esteban Domingo

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  1. Steinweg 28, Ettingen, CH-4107, Switzerland

    Ernst Jucker

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Domingo, E. (2003). Quasispecies and the development of new antiviral strategies. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 60. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8012-1_4

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