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Animal Models of Transmissible Spongiform Encephalopathies: Experimental Infection, Observation and Tissue Collection

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Techniques in Prion Research

Part of the book series: Methods and Tools in Biosciences and Medicine ((MTBM))

Abstract

From the early nineteenth century animal models increasingly contributed to the growing understanding of the nature and causes of infectious diseases [1]. Initially animal experimentation focussed on the demonstration of transmissibility, but the concept of animal models later broadened to encompass any condition found in an animal that is of value in studying a biological phenomenon Animal models range, therefore, from the selection for study of naturally occurring disorders in conveniently managed animal species, to the experimental reproduction of diseases in conventional, or genetically manipulated, host species, or different species. With increasing knowledge has come the universal realisation that experimental infections often differ in important respects from the natural disease they appear to mimic.

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Authors
  1. Gerald A. H. Wells
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  2. Stephen A. C. Hawkins
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Editor information

Editors and Affiliations

  1. Institut de Génétique Humaine, CNRS U.P.R. 1142, 141, rue de la Cardonille, Montpellier Cedex 5, F-34396, France

    Sylvain Lehmann

  2. Service de Pharmacologie et d’Immunologie, Bâtiment 136, CEA/Saclay, Gif sur Yvette Cedex, F-91191, France

    Jacques Grassi

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Wells, G.A.H., Hawkins, S.A.C. (2004). Animal Models of Transmissible Spongiform Encephalopathies: Experimental Infection, Observation and Tissue Collection. In: Lehmann, S., Grassi, J. (eds) Techniques in Prion Research. Methods and Tools in Biosciences and Medicine. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7949-1_5

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  • DOI: https://doi.org/10.1007/978-3-0348-7949-1_5

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-7643-2224-3

  • Online ISBN: 978-3-0348-7949-1

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