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Bone morphogenetic proteins and the synovial joints

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Bone Morphogenetic Proteins: Regeneration of Bone and Beyond

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Bone morphogenetic proteins (BMPs) are involved in a broad array of morphogenetic processes. These span from the specification of the dorso-ventral body axis to patterning, organogenesis and differentiation of most tissues. Nevertheless, the initial discovery of BMPs as protein preparations that induced ectopically and in vivo a cascade of endochondral bone formation in rats, has strongly stimulated the study of their role in the development of the skeleton and in patterning of the synovial joints [1-3]. Additionally, with their remarkable cartilage and bone morphogenetic activity, BMPs represent an attractive therapeutic option for skeletal and joint disorders. Indeed, growing scientific evidence supports the concept that tissue repair and regeneration recapitulates to a certain extent the process of tissue formation during embryonic development. Recent advances in unraveling the molecular basis of developmental processes support BMP signaling as potential targets in reparative approaches in joint diseases.

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Authors and Affiliations

  1. Laboratory of Skeletal Development and Joint Disorders, Department of Rheumatology, University Hospitals Leuven, Herestraat 49, Leuven, B-3000, Belgium

    Frank P. Luyten, Rik Lories & Dirk De Valck

  2. Department of Rheumatology, GKT School of Medicine, King’s College London, 5th Floor, Thomas Guy House, London, SE1 9RT, UK

    Cosimo De Bari & Francesco Dell’Accio

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  1. Frank P. Luyten
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  2. Rik Lories
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  3. Dirk De Valck
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  4. Cosimo De Bari
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  5. Francesco Dell’Accio
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Editors and Affiliations

  1. Laboratory for Mineralized Tissues, School of Medicine, Salata 11, Zagreb, HR, 10000, Croatia

    Slobodan Vukicevic

  2. Genzyme Corporation, One Mountain Road, Framingham, MA, 01701-9322, USA

    Kuber T. Sampath

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Luyten, F.P., Lories, R., De Valck, D., De Bari, C., Dell’Accio, F. (2004). Bone morphogenetic proteins and the synovial joints. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins: Regeneration of Bone and Beyond. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7857-9_9

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  • DOI: https://doi.org/10.1007/978-3-0348-7857-9_9

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9598-9

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