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Antidepressant Subclassification Based on the Quantitatively Analyzed Electrocorticogram of the Rat

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Animal Models in Psychopharmacology

Part of the book series: APS: Advances in Pharmacological Sciences ((APS))

Summary

Behavioural clinical data show different types of antidepressant drugs, e.g. sedating, stabilizing or activating ones. Another differentiation may be based on the presence or absence of anxiolytic activity. These different profiles can be recognized by the changes of the electrical brain activity induced by these drugs in humans and animals. Here we present a subclassification of antidepressant drugs based on the quantitative analysis of the ECoG of the rat. Subclass 1 is characterized by decrease of the power over the whole frequency range from 0 to 100 Hz indicating sedative activity. Subclass 2 is characterized by power changes characteristic for anxiolytic activity. Subclass 3 is characterized by power changes characteristic for stimulatory activity. The classification of drugs based on EcoG-profiles may be a relevant animal model to detect new antidepressants.

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Authors and Affiliations

  1. Department of Pharmacology, Duphar B.V., P.O. Box 900, 1380 DA, Weesp, The Netherlands

    F. Krijzer, R. van der Molen, B. Olivier & F. Vollmer

Authors
  1. F. Krijzer
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  2. R. van der Molen
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  3. B. Olivier
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  4. F. Vollmer
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Editor information

Editors and Affiliations

  1. CNS-Pharmacology, Duphar B.V., P.O. Box 900, 1380 DA, Weesp, The Netherlands

    B. Olivier  & J. Mos  & 

  2. Department of Psychopharmacology, Faculty of Pharmacy, University of Utrecht, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands

    J. L. Slangen

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© 1991 Springer Basel AG

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Krijzer, F., van der Molen, R., Olivier, B., Vollmer, F. (1991). Antidepressant Subclassification Based on the Quantitatively Analyzed Electrocorticogram of the Rat. In: Olivier, B., Mos, J., Slangen, J.L. (eds) Animal Models in Psychopharmacology. APS: Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6419-0_23

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  • DOI: https://doi.org/10.1007/978-3-0348-6419-0_23

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-6421-3

  • Online ISBN: 978-3-0348-6419-0

  • eBook Packages: Springer Book Archive

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