Abstract
Plants of the genus Aloe have perhaps the longest recorded history of medicinal usage and are amongst the most widely used plants for traditional medicinal purposes worldwide. Aloe vera , Aloe ferox , Aloe arborescens and Aloe perryi are the best known and most widely used, but many other species are also used for their therapeutic properties. The Aloes have been used since ancient times, particularly for the treatment of microbial infections, gastrointestinal disorders and inflammatory conditions. In addition to their myriad uses in traditional therapeutics, the Aloes have also been used as components of cosmetic formulations, and in the food and beverage industries. Despite their wide acceptance, studies from different laboratories often report wide variations in the therapeutic bioactivities from within the same Aloe species, even when the same extraction procedures are used. Furthermore, leaves from individual Aloe plants within the same species may have widely varying levels of the bioactive phytochemicals. Phytochemical analyses have shown that many Aloe species contain various carbohydrate polymers (notably glucomannans ) and a range of other low molecular weight phenolic compounds including alkaloids , anthraquinones , anthrones , benzene and furan derivatives , chromones , coumarins , flavonoids , phytosterols , pyrans and pyrones . There has been a wealth of information published about the phytochemistry and therapeutic potential of the Aloes (especially Aloe vera). Much of this has been contradictory. Intra- and interspecies differences in the redox state of the individual Aloe components and in the ratios of these components may occur between individual plants. These factors may all affect the physiological properties of Aloe extracts. Due to the structure and chemical nature of many of the Aloe phytochemicals, it is likely that many of the reported medicinal properties are due to antioxidant or prooxidant effects. The antioxidant/prooxidant activities of many Aloe phytochemicals depend not only on their individual levels, but also on the ratios between the various components and their individual redox states. Therefore, discrepancies between bioactivity studies are likely when using different crude mixtures. This report aims to summarise the phytochemistry of the Aloes and (a) examine how their constituents may be responsible for their medicinal properties and (b) some possible reasons for the wide variations reported for their medicinal properties and (c) their therapeutic mechanisms. Some future areas of research into the medicinal activities of this important genus are also highlighted.
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References
Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB (2005) Curcumin (diferuloylmethane) down regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IκBα kinase and Akt activation. Mol Pharmacol 69:195–206
Al-Fatimi M, Friedrich U, Jenett-Siems K (2005) Cytotoxicity of plants used in traditional medicine in Yemen. Fitoterapia 76:355–358
Ali MIA, Shalaby NMM, Elgamal MHA, Mousa ASM (1999) Antifungal effects of different plant extracts and their major components of selected Aloe species. Phytother Res 13:401–407
Alves DS, Perez-Fons L, Estepa A, Micol V (2004) Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin. Biochem Pharmacol 68:549–561
Anton R, Haag-Berrurier M (1980) Therapeutic use of natural anthraquinone for other than laxative actions. Pharmacology 20:104–112
Araya-Maturana R, Heredia-Moya J, Donoso-Tauda O, Vera M, Toledo Hernández J, Pavani M, Pessoa-Mahana H, Weiss-López B, Ferreira J (2008) Effects of simple and angular chromones on tumor cell respiration. Nat Prod Commun 3(4):519–525
Arunkumar S, Muthuselvam M (2009) Analysis of phytochemical constituents and antimicrobial activities of Aloe vera L. against clinical pathogens. World J Agricultural Sciences 5(5):572–576
Asamenew G, Bisrat D, Mazumder A, Asres K (2011) In vitro antimicrobial and antioxidant activities of anthrone and chromone from the latex of Aloe harlans Reynolds. Phytotherapy Research 25:1756–1760
Aslam K, Khosa MK, Jahan N, Nosheen S (2010) Synthesis and applications of coumarin. Pakistan J Pharmaceutical Sciences 23:449–454
Astaneie F, Afshari M, Mojtahedi A, Mostafalou S, Zamani MJ, Larijani B, Abdollah M (2005) Total antioxidant capacity and levels of epidermal growth factor and nitric oxide in blood and saliva of insulin-dependent diabetic patients. Arch Med Res 36(4):376–381
Awad AB, Toczek J, Carol CS, Fink S (2004) Phytosterols decrease prostaglandin release in cultured P388D1/MAB macrophages. Prostaglandins Leukot Essent Fatty Acids 70(6):511–520
Awad AB, Barta SL, Fink CS, Bradford PG (2008) beta-Sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism. Mol Nutr Food Res 52(4):419–426
Awadh Ali NA, Jülich WD, Kusnick C, Lindwquist U (2001) Screening of Yemeni medicinal plants for antibacterial and cytotoxic activities. J Ethnopharmacol 74:173–179
Azfal M, Ali RA, Hassan H, Sweedan N, Dhami MSI (1991) Identification of some prostanoids in Aloe vera extracts. Planta Med 57:38–40
Azghani AO, Williams I, Holiday DB, Johnson AR (1995) A beta-linked mannan inhibits adherence of Pseudomonas aeruginosa to human lung epithelial cells. Glycobiology 5:39–44
Babich H, Sedletcaia A, Kenigsberg B (2002) In vitro cytotoxicity of protocatechuic acid to cultured human cells from oral tissue: Involvement in oxidative stress. Pharmacol Toxicol 91:245–253
Baker A, Payne CM, Briehl MM, Powis G (1997) Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo. Cancer Res 57:5162–5167
Bancroft A, Myskja A (2003) Aloe vera: natures silent healer. BAAM Publishers, USA
Barrantes E, Guinea M (2003) Inhibition of collagenase and metalloproteinases by aloins and aloe gel. Life Sci 72:843–850
Beppu H, Koike T, Shimpo K, Chihara T, Hoshino M, Ida C, Kuzuya H (2003) Radical-scavenging effects of Aloe arborescens Miller on prevention of pancreatic islet B-cell destruction in rats. J Ethnopharmacol 83:37–45
Betterle C, Zanette F, Pedini B, Presotto F, Rapp LB, Monciotti CM, Rigon F (1984) Clinical and subclinical organ-specific autoimmune manifestations in type I (insulin-dependent) diabetic patients and their first-degree relatives. Diabetologia 26:431–436
Beubler E, Kollar G (1985) Stimulation of PGE2 synthesis and water and electrolyte secretion by senna anthraquinones is inhibited by indomethacin. J Pharm Pharmacol 37(4):248–251
Blitzke T, Porzel A, Masaoud M, Schmidt J (2000) A chlorinated amide and piperidine alkaloids from Aloe sabaea. Phytochemistry 55:979–982
Boudreau MD, Beland FA (2006) An evaluation of the biological and toxicological properties of Aloe barbadensis (Miller), Aloe vera. J Environ Sci Health Care 24:103–154
Brown NS, Bicknell R (2001) Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer. Breast Cancer Res 3:323–327
Burkill HM (1995) Useful plants of West Tropical Africa, vol 3. Royal Botanic Gardens, Kew
Carluccio MA, Sicuella L, Ancora MA, Massaro M, Scoditti E, Storelli C, Visioli F, Distante A De Caterina R (2003) Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arteriosclerosis, Thrombosis Vasc Biol 23:622–629
Casley-Smith JR, Gwyn Morgan R, Piller NB (1993) Treatment of lymphedema of the arms and legs with 5,6-benzo-α-pyrone. New England J Med 329:1158–1163
Chen YC, Shen SC, Lee WR, Hsu FL, Lin HY, Ko CH, Tseng SW (2002) Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Biochem Pharmacol 64:1713–1724
Chen W, Lu Z, Viljoen A, Hamman J (2009) Intestinal drug transport enhancement by Aloe vera. Planta Med 75(6):587–595
Chen W, van Wyk B, Vermaak I, Viljoen AM (2012) Cape aloes—A review of the phytochemistry, pharmacology and commercialisation of Aloe ferox. Phytochem Lett 5:1–12
Chithra P, Sajithlal GB, Chandrakasan G (1998a) Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats. J Ethnopharmacol 59(3):179–186
Chithra P, Sajithlal GB, Chandrakasan G (1998b) Influence of Aloe vera on the healing of dermal wounds in diabetic rats. J Ethnopharmacol 59:195–201
Chithra P, Sajithlal GB, Chandrakasan G (1998c) Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol Cell Biochem 181:71–76
Choi SW, Son BW, Son YI, Park YI, Lee SK, Chung MH (2001) The wound-healing effect of a glycoprotein fraction isolated from Aloe vera. Br J Dermatol 145(4):535–554
Chun-hui L, Chang-hai W, Zhi-liang X, Yi W (2007) Isolation, chemical characterization and antioxidant activities of two polysaccharides from the gel and the skin of Aloe barbadensis Miller irrigated with sea water. Process Biochem 42(6):961–970
Cock IE (2008) Antimicrobial activity of Aloe barbadensis Miller leaf gel components. Internet J Microbiol 4:2
Cock IE (2011) Problems of reproducibility and efficacy of bioassays using crude extracts, with reference to Aloe vera. Pharmacogn Commun 1(1):52–62
Cock IE, Kalt FR (2010) A modified MS2 bacteriophage plaque reduction assay for the rapid screening of antiviral plant extracts. Pharmacogn Res 2(4):221–228
Cock IE, Ruebhart D (2004) High performance liquid chromatographic separation and identification of a toxic fraction from Aloe barbadensis Miller leaf gel using the Artemia nauplii bioassay. Internet J Toxicol 4(2)
Cock IE, Ruebhart DR (2009) Comparison of the brine shrimp nauplii bioassay and the ToxScreen-II Test for the detection of toxicity associated with Aloe vera (Aloe barbadensis Miller) leaf extract. Pharmacogn J 1(2):98–101
Cock IE, Sirdaarta J (2011) Effect The toxicity of Aloe barbadensis Miller juice is due to the induction of oxidative stress. Adv Environ Biol 5(2):288–299
Dabai YU, Muhammad S, Aliyu BS (2007) Antibacterial activity of anthraquinone fraction of Vitex doniana. Pak J Biol Sci 1–3
Dagne E, Bisrat D, Viljoen A, van Wyk BE (2000) Chemistry of Aloe species. Curr Org Chem 4(10):1055–1078
Daisy BH, Strobel GA, Castillo U, Ezra D, Sears J, Weaver DK, Runyon JB (2002) Naphthalene, an insect repellent, is produced by Muscodor vitigenus, a novel endophytic fungus. Microbiology 148:3737–3741
Darokar MP, Rai R, Gupta AK, Shasany AK, Rajkumar S, Sunderasan V, Khanuja SPS (1999) Molecular assessment of germplasm diversity in Aloe spp. using RAPD and AFLP analysis. J Med Aromatic Plant Sci 25(2):354–361
Davi G, Ciabattoni G, Consoli A, Mezzetti A, Falco A, Santarone S, Pennese E, Vitacolonna E, Bucciarelli T, Constantini F, Capani F, Patrono C (1999) In vivo formation of 8-iso-prostaglandin F2a and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation 99:224–229
Davis W Ze’ev Ronai JR, Tew KD (2001) Cellular thiols and reactive oxygen species in drug-induced apoptosis. J Pharmacol Exp Ther 296(1):1–5
Davis RH, Kabbani JM, Maro NP (1987) Aloe vera and wound healing. J Am Podiatr Med Assoc 77:165–169
De Wet H, Nzama VN, van Vuuren SF (2012) Medicinal plants used for the treatment of sexually transmitted infections by lay people in northern Maputaland, KwaZulu-Natal Province, South Africa. S Afr J Botany 78:12–20
Dring JV, Nash RJ, Roberts MF, Reynolds T (1984) Hemlock alkaloids in Aloes. Occurrence and distribution of γ-coniceine. Planta Med 50(5):442–443
Eamlamnam K, Patumraj S, Visedopas N, Thong-Ngam D (2006) Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats. World J Gastroenterol 12(13):2034–2039
Eshun K, He Q (2004) Aloe vera: A valuable ingredient for the food, pharmaceutical and cosmetic industries—a review. Crit Rev Food Sci Nutr 44:91–96
Femenia A, Sanchez ES, Simal S, Rosello C (1999) Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohydr Polym 39:109–117
Ferro VA, Bradbury F, Cameron P, Shakir E, Rahman SR, Stimson WH (2003) In vitro susceptibilities of Shigella flexneri and Streptococcus pyogenes to inner gel of Aloe barbadensis Miller. Antimicrob Agents Chemother 47:1137–1139
Fleurentin J, Mazars G, Pelt JM (1983) Cultural background of the medicinal plants of Yemen. J Ethnopharmacol 7:183–203
Freemerman AJ, Powis G (2004) A redox-inactive thioredoxin reduces growth and enhances apoiptosis in WEHI7.2 cells. Biochem Biophys Res Commun 274:136–141
Gomes A, Neuwirth O, Freitas M, Couto D, Ribeiro D, Figueiredo AGPR, Silva AMS, Seixas RSGR, Pinto DCGA, Tomé AC, Cavaleiro JAS, Fernandes E, Lima JLFC (2009) Synthesis and antioxidant properties of new chromone derivatives. Bioorg Med Chem 17(20):7218–7226
Govindarajan R, Vijayakumar M, Pushpangadan P (2005) Antioxidant approach to disease management and the role of ‘Rasayana’ herbs of Ayuveda. J Ethnopharmacol 99:165–178
Grace OM, Simmonds MSJ, Smith GF, van Wyk AE (2008) Documented utility and biocultural value of Aloe L. (Asphodelaceae): a review. Econ Botany 63(2):167–178
Gupta R, Sharma AK, Dobhal M, Sharma M, Gupta R (2011) Antidiabetic and Antioxidant potential of β-sitosterol in Streptozotocin-induced experimental hyperglycemia. J Diabetes 3(1):29–37
Gutterman Y, Chauser-Volfson E (2000) The distribution of the phenolic metabolites barbaloin, aloeresin and aloenin as a peripheral defense strategy in the succulent leaf parts of Aloe arborescens. Biochem Syst Ecol 28(9):825–838
Habtemariam S (2010) Knipholone anthrone from Kniphofia foliosa induces a rapid onset of necrotic cell death in cancer cells. Fitoterapia 81:1013–1019
Halliwell B (1996) Vitamin C: antioxidant or pro-oxidant in vivo? Free Radical Res 25:439–454
Hamilos DL, Zelarney P, Mascali JJ (1989) Lymphocyte proliferation in glutathione-depleted lymphocytes: direct relationship between glutathione availability and the proliferative response. Immunopharmacology 18:223–235
Hamman JH (2008) Composition and applications of Aloe vera leaf gel. Molecules 13:1599–1616
Hamza OJM, van den Bout-van den Beukel CJP, Matee MIN, Moshi MJ, Mikx FHM, Selemani HO, Mbwambo ZH, Van der Ven AJAM, Verweij PE (2006) Antifungal activity of some Tanzanian plants used traditionally for the treatment of fungal infections. J Ethnopharmacol 108:124–132
Hatano T, Eubayashi H, Ito H, Shiota S, Tsuchiya T, Yoshida T (1999) Phenolic constituents of Cassia seeds and antibacterial effect of some naphthalenes and anthraquinones on methicillin-resistant Staphylococcus aureus. Chem Pharm Bull 47(8):1121–1127
Heinrich M, Ankli A, Frei B, Weimann C, Sticher O (1998) Medicinal plants in Mexico: Healers’ consensus and cultural importance. Soc Sci Med 47(11):1859–1871
Herbert V, Shaw S, Jayatileke E (1996) Vitamin C driven free radicals generation from iron. J Nutr 126:1213–1220
Hertog MG, Bueno-de-Mesquita HB, Fehily AM, Sweetnam PM, Elwood PC, Kromhout D (1996) Fruit and vegetable consumption and cancer mortality in the caerphilly study. Cancer Epidemiol Biomark Prev 5:673–677
Hu Y, Xu J, Hu Q (2003) Evaluation of antioxidant potential of Aloe vera (Aloe barbadensis Miller) extracts. J Agric Food Chem 51:7788–7791
Huang HC, Chang JH, Tung SF, Wu RT, Foegh ML, Chu SH (1992) Immunosuppressive effect of emodin, a free radical generator. Eur J Pharmacol 211:359–364
Hutchings A, Scott AH, Lewis G, Cunningham A (1996) Zulu medicinal plants: an inventory. University of Natal Press, Pietmaritzburg, South Africa
Hutter JA, Salman M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT, Weintraub ST (1996) Antiinflammatory C-glucosyl chromone from Aloe barbadensis. J Nat Prod 59:541–543
Im SA, Oh ST, Song S, Kim MR, Kim DS, Woo SS, Jo TH, Park YI, Lee CK (2005) Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity. Int Immunopharmacol 5:271–279
Ishii Y, Tanizawa H, Takino Y (1994) Studies of aloe. V. Mechanism of cathartic effect. Biol Pharm Bull 17:651–653
Ito S, Teradaira R, Beppu H, Obata M, Nagatsu T, Fujita K (1993) Properties and pharmacological activity of carboxypeptidase in Aloe arborescens Mill var. natalensis Berger. Phytother Res 7:26–29
Jeruto P, Lukhoba C, Ouma G, Otieno D, Mutai C (2008) An ethnobotanical study of medicinal plants used by the Nandi people of Kenya. J Ethnopharmacol 116:370–376
Jettanacheawchankit S, Sasithanasate S, Sangvanich P, Banlunara W, Thunyakitpisal P (2009) Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type 1 collagen; and wound healing. J Pharmacol Sci 109:525–531
Yun JM, Singh S, Jialal, R, Rockwood J, Jialal I, devaraj S (2010) A randomized placebo-controlled crossover trial of Aloe vera on bioavailability of vitamins C and B12, blood glucose, and lipid profile in healthy human subjects. J Dietary Suppl 7(2):145–153
Joel LS (1995) The dual roles of nutrients as antioxidants and pro-oxidants: their effects of tumor cell growth. In: Herbert V (ed) Proceeding of the “Prooxidant Effects of Antioxidant Vitamins” experimental biology meeting, Atlanta, GA. American Society of Nutrition 1995, Bethesda, MD, pp 1221–1226
Joseph B, Raj SJ (2010) Pharmacognostic and phytochemical properties of Aloe vera Linn—an overview. Int J Pharm Sci Rev Res 4(2):106–110
Kahlon J, Kemp MC, Yawei N, Carpenter RH, McAnalley HR, Shannon WM, McDaniel BH (1991) An evaluation of the synergistic antiviral effects of acemannan in combination with azidothymidine and acyclovir. Mol Biother 3:214–223
Kameyama S, Shinho M (1980) Wound healing compositions from Aloe arborescens extracts. Japanese Patent 79, 151, 113, Chemical Abstracts, vol 93, p 10375y
Kapoor LD (1990) Handbook of Ayuvedic medicinal plants. CRC Press, Washington DC
Kigondu EVM, Rukunga GM, Keriko JM, Tonui WK, Gathirwa JW, Kirira PG, Irungu B, Ingonga JM, Ndiege IO (2009) Anti-parasitic activity and cytotoxicity of selected medicinal plants from Kenya. J Ethnopharmacol 123:504–509
Kim HS, Lee JH, Kim IK (1996) Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2. Prostaglandins 51:413–425
Klein R (1995) Hyperglycemia and microvascular and macrovascular disease in diabetes. Diabetes Care 18:258–268
Köhler FE (1887) Medizinal-Pflanzen in naturgetreuen Abbildungenmit kurz erläuterndem Texte: Atlas zur Pharmacopoea germanica 1887; Leipzig: Gera-Untermhaus, illustrated by Müeller L, Schmidt CF, and Gunther K
Kouassi Y, Shelef LA (1998) Inhibition of Lysteria monocytogenes by cinnamic acid: possible interaction of the acid with cysteinyl residues. J Food Saf 18(3):231–242
Kuo YC, Meng HC, Tsai WJ (2001) Regulation of cell proliferation, inflammatory cytokine production and calcium mobilization in primary human T lymphocytes by emodin from Polygonum hypoleucum Ohwi. Inflamm Res 50:73–82
Lamorde M, Tabuti JRS, Obua C, Kukunda-Byobona C, Lanyero H, Byakika-Kibwika P, Bbosa GS, Lubega A, Ogwal-Okeng J, Ryan M, Waako PJ, Merry C (2010) Medicinal plants used by traditional medicine practitioners for the treatment of HIV/AIDS and related conditions in Uganda. J Ethnopharmacol 130:43–53
Langmead L, Makins RJ, Rampton DS (2004) Anti-inflammatory effects of aloe vera gel in colorectal mucosa in vitro. Ailment Pharmacology and Therapeutics 19:521–527
Lastra CA, Villegas I (2007) Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. Biochem Soc Trans 35:1156–1160
Lawrence R, Tripathi P, Jeyakumar E (2009) Isolation, purification and evaluation of antibacterial agents from Aloe vera. Braz J Microbiol 40:906–915
Lee HZ (2001) Protein kinase C involvement in aloe-emodin and emodin-induced apoptosis in lung carcinoma cell. Br J Pharmacol 134:1093–1103
Lee CK (2006) Immunomodulatory activity, in new perspectives on Aloe. In: Park YI, Lee SK (eds). Springer, Heidelberg
Lee KY, Park JH, Chung MH, Park YI, Kim KW, Lee YJ, Lee SK (1997) Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells. IUBMB Life 41(2):285–292
Lee HZ, Hsu SL, Liu MC, Wu CH (2001) Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma. Eur J Pharmacol 431:287–295
Lee A, Chui PT, Aun CS, Gin T, La AS (2004) Possible interaction between sevoflurane and Aloe vera. Ann Pharmacother 38:1651–1654
Leng-Peschlow E (1986) Dual effect of orally administered sennosides on large intestine transit and fluid absorption in the rat. J Pharm Pharmacol 38:606–610
Levin H, Hazenfratz R, Friedman J, Palevitch D, Perl M (1988) Partial purification and some properties of an antibacterial compound from Aloe vera. Phytother Res 2:67–69
Lin SZ, Tong HF, Chen KG, Jing H, Yang X, Zheng SS (2010) Effect of emodin in suppressing acute rejection following liver allograft transplantation in rats. Chin J Integr Med 16(2):151–156
Liu L, Hudgins WR, Shack S, Yin MQ, Samid D (1995) Cinnamic acid: a natural product with potential users in cancer intervention. Int J Cancer 62(3):345–350
Lodovici M, Guglielmi F, Meoni M, Dolara P (2001) Effect of natural phenolic acids on DNA oxidation in vitro. Food Chemistry and Toxicology 39:1205–1210
Lorenzetti LJ, Salisbury R, Beal JL, Baldwin JN (1964) Bacteriostatic property of Aloe vera. J Pharm Sci 53:1287
Mabona U, van Vuuren SF (2013) Southern African medicinal plants used to treat skin diseases. S Afr J Botany 87:175–193
Macpherson G (1992) Inflammation. Blacks Medical Dictionary A and C Black, London, UK
Makino Y, Yoshikawa N, Okamoto K, Hirota K, Yodoi J, Makino I, Tanaka H (1999) Direct association with thioredoxin allows redox regulation of glucocorticoid receptor function. J Biol Chem 274:3182–3188
Malterud KE, Farbrot TL, Huse AE, Sund RB (1993) Antioxidant and radical scavenging effects of anthraquinones and anthrones. Pharmacology 47:77–85
Manojlovic NT, Solujic S, Sukdolak S (2002) Antimicrobial activity of an extract and anthraquinones from Caloplaca schaereri. The Lichenologist 34:83–85
Martikainen JA, Ottelin AM, Kiviniemi V, Gylling H (2007) Plant stanol esters are potentially cost-effective in the prevention of coronary heart disease in men: Bayesian modelling approach. Eur J Cardiovasc Prev Rehab 14:265–272
Marwah RG, Majekodunmi OF, Al Mahrooqi R, Varma GB, Al Abadi H, Al-Burtamani SKS (2007) Antioxidant capacity of some edible and wound healing plants in Oman. Food Chem 101:465–470
Masella RA, Cantafora D, Modesti A, Cardilli L, Gennaro A, Bocca E (1999) Antioxidant activity of 3,4-DHPEA-EA and protocatechuic acid: a comparative assessment with other olive oil biophenols. Redox Repair 4:113–121
Maurya DK, Devasagayam TPA (2010) Antioxidant and prooxidant nature of hydroxycinnamic acid derivatives ferulic and caffeic acids. Food Chem Toxicol 48:3369–3373
Middleton E, Kandaswami C, Theorharides TC (2000) The effect of plant flavonoids on mammalian cells: inflammation, heart disease and cancer. Pharmacol Rev 52:673–751
Moon EJ, Lee YM, Lee OH, Lee MJ, Lee SK, Chung MH, Park YI, Sung CK, Choi JS, Kim KW (1999) A novel angiogenic factor derived from Aloe vera gel: b-sitosterol, a plant sterol. Angiogenesis 3:117–123
Morton JF (1981) Atlas of medicinal plants of middle America, Bahamas to Yucatan. Springfield, IL, USA
Mothana RA, Lindequist U, Gruenert R, Bednarski PJ (2009) Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island of Soqotra. BMC Complement Altern Med 9:7
Mothana RA, Al-Musayeib NM, Matheeussen A, Cos P, Maes L (2012) Assessment of the in vitro antiprotozoal and cytotoxic potential of 20 selected medicinal plants from the island of Soqotra. Molecules 17:14349–14360. doi:10.3390/molecules171214349
Mpala L, Chikowe G, Cock IE (2010) No evidence of antiseptic properties and low toxicity of selected Aloe species. J Pharm Negative Results 1(1):10–16
Muthee JK, Gakuya DW, Mbaria JM, Kareru PG, Mulei CM, Njonge FK (2011) Ethnobotanical study of anthelmintic and other medicinal plants traditionally used in Loitoktok district of Kenya. J Ethnopharmacol 135:15–21
Nakamura Y, Torikai K, Ohto Y, Murakami A, Tanaka T, Ohigashi H (2000) A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: dose and timing-dependent enhancement and involvement of bioactivation by tyrosinase. Carcinogenesis 21(10):1899–1907
Nanyingi MO, Mbaria JM, Lanyasunya AL, Wagate CG, Koros KB, Kaburia HF, Munenge RW, Ogara WO (2008) Ethnopharmacological study of Samburu district, Kenya. J Ethnobiol Ethnomed 4:14
Ndhlala AR, Amoo SO, Stafford GI, Finnie JF, van Staden J (2009) Antimicrobial, anti-inflammatory and mutagenic investigation of the South African tree aloe (Aloe barberae). J Ethnopharmacol 124:404–408
Nguta JM, Mbaria JM, Gakuya DW, Gathumbi PK, Kiama SG (2010a) Antimalarial herbal remedies of Msambweni, Kenya. J Ethnopharmacol 128:424–432
Nguta JM, Mbaria JM, Gakuya DW, Gathumbi PK, Kiama SG (2010b) Traditional antimalarial phytotherapy remedies used by the South Coast community, Kenya. J Ethnopharmacol 131:256–267
Ni Y, Tizard IR (2004) Analytical methodology: the gel-analysis of aloe pulp and its derivatives. In: Reynolds T (ed) Aloes the genus Aloe. CRC Press, Boca Raton, pp 111–126
Ni Y, Turner D, Yates KM, Tizard I (2004) Isolation and characterisation of structural components of Aloe vera L. leaf pulp. Int Immunopharmacol 4:1745–1755
Njoroge GN, Bussman RW (2007) Ethnotherapeutic management of skin diseases among the Kikuyus of central Kenya. J Ethnopharmacol 111:303–307
Neuwinger HD (1998) Afrikanische Arzneipflanzen und Jagdgifte: Chemie, Pharmakologie, Toxikologie, Aloeaceae. Stuttgart Wis-senschaftliche Verlagsgesellschaft mbH: 1–7
Okamoto K, Tanaka H, Ogawa H, Makino Y, Eguchi H, Hayashi S, Yoshikawa N, Poellinger L, Umesono K, Makino I (1999) Redox-dependent regulation of nuclear import of the glucocorticoid receptor. J Biol Chem 274:10363–10371
Okyar A, Can A, Akev N, Baktir G, Sütlüpinar N (2001) Effect of Aloe vera leaves on blood glucose level in type I and type II rat models. Phytother Res 15(2):157–161
Pandey R, Mishra A (2010) Antibacterial activities of crude extract of Aloe barbadensis to clinically isolated bacterial pathogens. Appl Biochem Biotechnol 160(5):1356–1361
Park BS, Lee KY, Lee SE, Piao XL, Takeoda GR, Wong RY, Ahn YJ, Kim JH (2006) Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori. J Ethnopharmacol 105:255–262
Park MY, Kwon HJ, Sung MK (2009) Intestinal absorption of aloin, aloe emodin, and aloesin; a comparative study using two in vitro absorption models. Nutr Res Pract 3(1):9–14
Pecere T, Gazzola MV, Mucignat C, Parolin C, Vecchia FD, Cavaggioni A, Basso G, Diaspro A, Salvato B, Carli M, Palù G (2000) Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res 60:2800–2804
Peluso MR (2006) Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase and modulate lipid homeostasis in adipose tissue and liver. Exp Biol Med (Maywood) 231:1287–1299
Penckofer S, Schwertz D, Florczak K (2002) Oxidative stress and cardiovascular disease in type 2 diabetes: the role of antioxidants and prooxidants. J Cardiovasc Nurs 16(2):68–85
Pugh N, Ross SA, ElSohly MA, Pasco DS (2001) Characterisation of aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity. J Agric Food Chem 49:1030–1034
Pyke DA (1977) Genetics of diabetes. J Clin Endocrinol Metab 6:285–303
Qiu Z, Jones K, Wylie M, Jia Q, Orndorff S (2000) Modified Aloe barbadensis polysaccharide with immunoregulatory activity. Planta Med 66:152–156
Rahimi R, Nikfar S, Larijani B, Abdollahi M (2005) A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother 59:365–373
Rahman A, Shahabuddin M, Hadi SM, Parish J (1990) Complexes involving quercetin, DNA and Cu(II). Carcinogenesis 11:2001–2003
Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S (2004) Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 7(1):61–66
Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S (2005) Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacol Rep 57:90–96
Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S (2006) Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol 33:232–237
Ramamoorthy L, Tizard IR (1998) Induction of apoptosis in a macrophage cell line RAW 264.7. Mol Pharmacol 53:415–421
Ramamoorthy L, Kemp MC, Tizard IR (1993) Effects of acemannan on the production of cytokine in a macrophage cell line RAW264.7. Abstracts of the Joint Meeting of the European Tissue Repair Society and Wound Healing Society, Amsterdam, The Netherlands
Ramamoorthy L, Kemp MC, Tizard IR (1996) Acemannan, a beta-(1,4)-acetylated mannan, induces nitric oxide production in macrophage cell line RAW 264.7. Mol Pharmacol 50:878–884
Reynolds T (2004) Aloe chemistry. In: Reynolds T (ed) Aloes the genus Aloe. CRC Press, Boca Raton, pp 39–74
Reynolds T (2005) Molecules of interest. Hemlock alkaloids from Socrates to poison aloes. Phytochemistry 66:1399–1406
Rice-Evans C, Miller N (1997) Paganga. Antioxidant properties of phenolic compound. Trends Plant Sci 2:152–159
Robertson RP, Chen M (1977) A role for prostaglandin E in defective insulin secretion and carbohydrate intolerance in diabetes mellitus. J Clin Investig 60:747–753
Ruefli AA, Davis JE, Sutton VR, Trapani JA, Smyth MJ, Johnstone RW (2001) Dissecting the apoptopic mechanisms of chemotherapeutic drugs and lymphocytes to design effective anticancer therapies. Drug Dev Res 52:549–557
Ruff JC (2003) Wine and polyphenols related to platelet aggregation and atherothrombosis. Drugs Exp Clin Res 25:125–131
Saada HN, Ussama ZS, Mahdy AM (2003) Effectiveness of Aloe vera on the antioxidant status of different tissues in irradiated rats. Pharmazie 58:929–931
Samuni A, Aronovitch J, Godinger D, Chevion M, Czapsk G (1983) On the cytotoxicity of vitamin C and metal ions. A site-specific Fenton mechanism. Eur J Biochem 137:119–124
Saoo K, Miki H, Ohmori M, Winters WD (1996) Antiviral Activity of Aloe Extracts against cytomegalovirus. Phytother Res 10:348–350
Saxena A, Bhatnagar M, Garg NK (1984) Enzyme changes in rat tissues during hyperglycemia, Arogya. J Health Sci 10:33–37
Saxena AK, Srivastava P, Baquer NZ (1992) Effects of vanadate on glycolytic enzyme and malic enzyme in insulin dependent and independent tissues of diabetic rats. Eur J Pharmacol 216:123–126
Shih CC, Wu YW, Lin WC (2002) Antihyperglycemic and antioxidant properties of Anoectochilus Formosanus in diabetic rats. Clin Exp Pharmacol Physiol 29:684–688
Shim SM, Kwon HJ (2010) Assessing absorbability of bioactive components in Aloe using in vitro digestion model with human intestinal cells. J Food Biochem 34:425–438
Grace OM, Simmonds, MSJ, Smith GF, van Wyk AE (2009) Therapeutic uses of Aloe L. (Asphodelaceae) in southern Africa. J Ethnopharmacol 119:604–614
Simons SS, Pratt WB (1995) Glucocorticoid receptor thiols and steroid-binding activity. Methods Enzymol 251:406–422
Singh S, Farhan AS, Ahmad A, Khan NU, Hadi SM (2001a) Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II). Cancer Lett 169:139–146
Singh R, Barden A, Mori T, Beilin L (2001b) Advanced glycation end-products: a review. Diabetologia 44:129–146
Sirdaarta J, Cock IE (2008) Vitamin E and Trolox™ reduce toxicity of Aloe barbadensis Miller juice in Artemia franciscana nauplii but individually are toxic at high concentrations. Internet J Toxicol 5:1
Sirdaarta J, Cock IE (2010) Effects of Aloe barbadensis Miller juice on oxidative stress biomarkers in aerobic cells using Artemia franciscana as a model. Phytother Res 24:360–364
Speranza G, Manitto P, Cassara P, Monti D (1993) Feralolide, a dihydroisocoumarin from Cape Aloe. Phytochemistry 33:175
Steenkamp V (2003) Traditional herbal remedies used by South African women for gynaecological complaints. J Ethnopharmacol 86:97–108
Suvitayavat W, Sumrongkit C, Thirawarapan SS, Bunyapraphatsara N (2004) Effects of Aloe preparation on the histamine-induced gastric secretion in rats. J Ethnopharmacol 90:239–247
Tager H (1984) Abnormal products of human insulin gene. Diabetes 33:693–699
Tai-Nin Chow J, Williamson DA, Yates KM, Goux WJ (2005) Chemical characterization of the immunomodulating polysaccharide of Aloe vera L. Carbohydr Res 340(6):1131–1142
Tan BKH, Vanitha J (2004) Immunomodulatory and antibacterial effects of some traditional Chinese medicinal herbs: a review. Curr Med Chem 11:1423–1430
Tian B, Hua Y (2005) Concentration-dependence of prooxidant and antioxidant effects of aloin and aloe-emodin on DNA. Food Chem 91:413–418
Tobias PV (1957) Bushmen of the Kalahari. Man 57:33–40
Tome ME, Baker AF, Powis G, Payne CM, Briehl MM (2001) Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growth. Cancer Res 61:2766–2773
Treutlein J, Smith GFS, van Wyk BE, Wink W (2003) Phylogenetic relationships in Asphodelaceae (Alooideae) inferred from chloroplast DNA sequences (rbcl, matK) and from genomic finger-printing (ISSR). Taxon 52(2):193–207
Tsuda T, Horio F, Uchida K, Aoki H, Osawa T (2003) Dietary cyanidin 3-O-b- D-glucoside-rich purple corn colour prevents obesity and ameliorates hyperglycemia in mice. J Nutr 133:2125–2130
Ubbink-Kok T, Anderson JA, Konings WN (1986) Inhibition of electron transfer and uncoupling effects by emodin and emodinanthrone in Escherichia coli. Antimicrob Agents Chemother 30(1):147–151
van Gorkom BA, de Vries EG, Karrenbeld A, Kleibeuker JH (1999) Review article: anthranoid laxatives and their potential carcinogenic effects. Aliment Pharmacol Ther 13:443–452
van Vuuren SF, Naidoo D (2010) An antimicrobial investigation of plants used traditionally in southern Africa to treat sexually transmitted infections. J Ethnopharmacol 130:552–558
van Wyk BE (2008a) A review of Khoi-San and Cape Dutch medical ethnobotany. J Ethnopharmacol 119(3):331–341
van Wyk BE (2008b) A broad review of commercially important southern African medicinal plants. J Ethnopharmacol 119(3):342–355
van Wyk BE, Smith G (2008) Guide to the Aloes of South Africa, 2nd edn. Briza Publications, Pretoria
van Wyk BE, van Rheede van Oudtshoorm MCB, Smith GF (1995) Geographical variation in the major compounds of Aloe ferox leaf exudates. Planta Medica 61:250–253
van Wyk BE, De Wet H, van Heerden FR (2008) An ethnobotanical survey of medicinal plants in the southeastern Karoo, South Africa. S Afr J Botany 74(4):696–704
Veitch NC, Simmonds MSJ, Blaney WM, Reynolds T (1994) A dihydroisocoumarin glucoside from Aloe hildebrandtii. Phytochemistry 35:1163–1166
Vessby J, Basu S, Mohsen R, Berne C, Vessby B (2002) Oxidative stress and antioxidant status in type 1 diabetes mellitus. J Intern Med 251:69–76
Viljoen A (1999) A chemotaxonomic study of phenolic leaf compounds in the genus Aloe. Doctoral thesis, Rand Afrikaans University, South Africa
Vita JA (2005) Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am J Clin Nutr 81:292S–297S
Vivancos M, Moreno JJ (2005) β-Sitosterol modulates antioxidant enzyme response in RAW 264.7 macrophages. Free Radic Biol Med 39(1):91–97
Wagate CG, Mbaria JM, Gakuya DW, Nanyingi MO, Kareru PG, Njuguna A, Gitahi N, Macharia JK, Njonge FK (2010) Screening of some Kenyan medicinal plants for antibacterial activity. Phytother Res 24:150–153
Wambugu SN, Mathiu PM, Gakuya DW, Kanui TI, Kabasa JD, Kiama SG (2011) Medicinal plants used in the management of chronic joint pains in Machakos and Makueni counties, Kenya. J Ethnopharmacol 137:945–955
Wang BS, Murdock KC, Lumanglas AL, Damiani M, Silva J, Ruszala-Mallon VM, Durr FE (1987) Relationship of chemical structures of anthraquinones with their effects on the suppression of immune responses. Int J Immunopharmacol 9(6):733–739
Watt JM, Breyer-Brandwijk MG (1962) The medicinal and poisonous plants of southern and eastern Africa, 2nd edn. Livingstone, London UK
Weir TL, Park SW, Vivanco JM (2004) Biochemical and physiological mechanisms mediated by allelochemicals. Curr Opin Plant Biol 7:472–479
Whitlon DS, Sadowski JA, Suttie JW (1978) Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition. Biochemistry 17(8):1371–1377
Wienbeck M, Kortenhaus E, Wallenfels M, Karaus M (1988) Effect of sennosides on colon motility in cats. Pharmacology 36:31–39
Wolfle D, Schmutte C, Westendorf J, Marquardt H (1990) Hydroxyanthraquinones as tumor promoters: enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes. Cancer Res 50:6540–6544
Wondimu T, Asfaw Z, Kelbessa E (2007) Ethnobotanical study of medicinal plants around ‘Dheeraa’ town, Arsi Zone, Ethiopia. J Ethnopharmacol 112:152–161
Wu JH, Xu C, Shan CY, Tan RX (2006) Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var, Chinensis. Life Sci 78:622–630
Wu CC, Lu YH, Wei BL, Yang SC, Won SJ, Lin CN (2008) Phloroglucinols with prooxidant activity from Garcinia subelliptica. J Nat Prod 71:246–250
Wynn RL (2005) Aloe vera gel: update for dentistry. General Dentistry 53:6–9
Yagi A, Kabash A, Okamura N, Haraguchi H, Moustafa SM, Khalifa TI (2002) Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Planta Med 68(11):957–960
Yan Y, Su X, Liang Y, Zhang J, Shi C, Lu Y, Gu L, Fu L (2008) Emodin azide methyl anthraquinone derivative triggers mitochondrial-dependent cell apoptosis involving in caspase-8-mediated Bid cleavage. Mol Cancer Ther 7:1688–1697
Yang H, Xu L, He C, Liu X, Fang R, Ma T (2011) CFTR chloride channel as a molecular target of anthraquinone compounds in herbal laxatives. Acta Pharmacol Sin 32:834–839
Yen GC, Duh PD, Chuang DY (2000) Antioxidant activity of anthraquinones and anthrone. Food Chem 70:437–441
Yoon JW, Austin M, Onodera T, Notkins AC (1979) Virus induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300:1173–1179
York T, de Wet H, van Vuuren SF (2011) Plants used for treating respiratory infections in rural Maputaland, KwaZulu-Natal, South Africa. J Ethnopharmacol 135:696–710
Youdim KA, Spencer JP, Schroeter H, Rice-Evans CA (2002) Dietary flavonoids as potential neuroprotectants. Biol Chem 383:503–519
Yusuf S, Agunu A, Diana M (2004) The effect of Aloe vera A. berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats. J Ethnopharmacol 93:33–37
Zhang L, Tizard IR (1996) Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Immunopharmacology 35:119–128
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Cock, I.E. (2015). The Genus Aloe: Phytochemistry and Therapeutic Uses Including Treatments for Gastrointestinal Conditions and Chronic Inflammation. In: Rainsford, K., Powanda, M., Whitehouse, M. (eds) Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases. Progress in Drug Research, vol 70. Springer, Basel. https://doi.org/10.1007/978-3-0348-0927-6_6
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