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Understanding B Cell Biology

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Drugs Targeting B-Cells in Autoimmune Diseases

Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

Humoral autoimmunity reflects failures in B cell tolerance and regulation. Accordingly, B cells have long been proposed as targets for treating autoimmune disease. The last decade has witnessed substantial growth in the number of therapeutic agents that target B cells themselves, or molecules key to B cell survival or function. In order to understand, develop, and eventually predict the outcomes of B cell targeted therapies, a thorough understating of the mechanisms underlying B cell development, activation, and regulation is necessary. Here we summarize B cell genesis, differentiation, and tolerance, and illustrate how an understanding of basic B cell biology can afford insight into the design and action of therapeutic agents.

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  1. Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104-6082, USA

    Martin S. Naradikian, Jean L. Scholz, Michael A. Oropallo & Michael P. Cancro

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  1. Martin S. Naradikian
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  2. Jean L. Scholz
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  3. Michael A. Oropallo
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  4. Michael P. Cancro
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Correspondence to Michael P. Cancro .

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  1. Hospital Clinic, Department of Internal Medicine, University of Barcelona, Barcelona, Spain

    Xavier Bosch

  2. Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain

    Manuel Ramos-Casals

  3. King's College, The Rayne Institute, St. Thomas' Hospital, London, United Kingdom

    Munther A Khamashta

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Naradikian, M.S., Scholz, J.L., Oropallo, M.A., Cancro, M.P. (2014). Understanding B Cell Biology. In: Bosch, X., Ramos-Casals, M., Khamashta, M. (eds) Drugs Targeting B-Cells in Autoimmune Diseases. Milestones in Drug Therapy. Springer, Basel. https://doi.org/10.1007/978-3-0348-0706-7_2

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