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Revisiting the Daily Timing of POS Phagocytosis

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Retinal Degenerative Diseases XIX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1415))

Abstract

Retinal pigment epithelium (RPE) cells daily ingest the tips of the photoreceptor outer segments (POSs), with phagosome number varying throughout a 24-h cycle. A major focus in the literature has been on a peak in phagosome concentration shortly after lights-on. Moreover, this peak has frequently been inferred to represent a peak in POS tip ingestion. Here, we have reviewed old and new literature on the daily cycle of phagosome number in the RPE and conclude that there is more variation in the timing of phagosome concentration peaks than is currently acknowledged. We also discuss that phagosome quantity is affected by the rate of phagosome degradation as well as the rate of ingestion; given that phagosome half-life may not be constant throughout the daily cycle, maximal POS ingestion may not necessarily coincide with a peak in phagosome concentration.

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Acknowledgments

The authors are supported by a BrightFocus Foundation postdoctoral fellowship (A.E.P., M2021004F) and NIH R01EY027442 grant.

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Authors and Affiliations

  1. Departments of Ophthalmology and Neurobiology, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Antonio E. Paniagua, Harjas S. Sabharwal, Kausalya Kethu, Andrew W. Chang & David S. Williams

Authors
  1. Antonio E. Paniagua
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  2. Harjas S. Sabharwal
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  3. Kausalya Kethu
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  4. Andrew W. Chang
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  5. David S. Williams
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Corresponding authors

Correspondence to Antonio E. Paniagua or David S. Williams .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    John D. Ash

  2. Ocular Genomics InstituteDepartment of OphthalmologyMassachusetts Eye and Ear InfirmaryHarvard Medical School, Boston, MA, USA

    Eric Pierce

  3. Health Sciences Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Robert E. Anderson

  4. Department of Ophthalmology, Duke Medical Center, Durham, NC, USA

    Catherine Bowes Rickman

  5. Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA

    Joe G. Hollyfield

  6. Laboratory for Retinal Cell BiologyDepartment of OphthalmologyUniversity Hospital Zurich, University of Zurich, Schlieren, Switzerland

    Christian Grimm

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© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Cite this paper

Paniagua, A.E., Sabharwal, H.S., Kethu, K., Chang, A.W., Williams, D.S. (2023). Revisiting the Daily Timing of POS Phagocytosis. In: Ash, J.D., Pierce, E., Anderson, R.E., Bowes Rickman, C., Hollyfield, J.G., Grimm, C. (eds) Retinal Degenerative Diseases XIX. Advances in Experimental Medicine and Biology, vol 1415. Springer, Cham. https://doi.org/10.1007/978-3-031-27681-1_75

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