Abstract
During ageing molecular damage leads to the accumulation of several hallmarks of ageing including mitochondrial dysfunction, cellular senescence, genetic instability and chronic inflammation, which contribute to the development and progression of ageing-associated diseases including cardiovascular disease. Consequently, understanding how these hallmarks of biological ageing interact with the cardiovascular system and each other is fundamental to the pursuit of improving cardiovascular health globally. This review provides an overview of our current understanding of how candidate hallmarks contribute to cardiovascular diseases such as atherosclerosis, coronary artery disease and subsequent myocardial infarction, and age-related heart failure. Further, we consider the evidence that, even in the absence of chronological age, acute cellular stress leading to accelerated biological ageing expedites cardiovascular dysfunction and impacts on cardiovascular health. Finally, we consider the opportunities that modulating hallmarks of ageing offer for the development of novel cardiovascular therapeutics.
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Acknowledgements
The authors acknowledge the contribution of past and present members of the laboratory of G.R who have contributed to the data discussed in this review. We acknowledge the funding support of the British Heart Foundation PG/22/10788 and PG/21/10761. Figures were created with BioRender.com.
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Booth, L.K., Redgrave, R.E., Tual-Chalot, S., Spyridopoulos, I., Phillips, H.M., Richardson, G.D. (2023). Heart Disease and Ageing: The Roles of Senescence, Mitochondria, and Telomerase in Cardiovascular Disease. In: Harris, J.R., Korolchuk, V.I. (eds) Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science. Subcellular Biochemistry, vol 103. Springer, Cham. https://doi.org/10.1007/978-3-031-26576-1_4
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